The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis
Open accessAbstract
Heart formation requires the coordinated recruitment of multiple cardiac progenitor cell populations derived from both the first and second heart fields. In this study, we have ablated the Bmp receptor 1a and the Wnt effector β-catenin in the developing heart of mice by using MesP1-cre, which acts in early mesoderm progenitors that contribute to both first and second heart fields. Remarkably, the entire cardiac crescent and later the primitive ventricle were absent in MesP1-cre ; BmpR1a lox/lox mutants. Although myocardial progenitor markers such as Nkx2-5 and Isl1 and the differentiation marker MLC2a were detected in the small, remaining cardiac field in these mutants, the first heart field markers, eHand and Tbx-5 , were not expressed. We conclude from these results that Bmp receptor signaling is crucial for the specification of the first heart field. In MesP1-cre; β -catenin lox/lox mutants, cardiac crescent formation, as well as first heart field markers, were not affected, although cardiac looping and right ventricle formation were blocked. Expression of Isl1 and Bmp4 in second heart field progenitors was strongly reduced. In contrast, in a gain-of-function mutation of β-catenin using MesP1-cre, we revealed an expansion of Isl1 and Bmp4 expressing cells, although the heart tube was not formed. We conclude from these results that Wnt/β-catenin signaling regulates second heart-field development, and that a precise amount and/or timing of Wnt/β-catenin signaling is required for proper heart tube formation and cardiac looping.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jho, E.-H., Zhang, T., Domon, C., Joo, C.-K., Freund, J.-N., & Costantini, F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1172-1183.2002 · Cited by 1,678
Cai, C.-L., Liang, X., Shi, Y., Chu, P.-H., Pfaff, S. L., Chen, J., & Evans, S. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00363-0 · Cited by 1,610
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,353
Self-citationIntestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene
Harada, N. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.5931 · Cited by 1,212
Building the mammalian heart from two sources of myocardial cells
Buckingham, M., Meilhac, S., & Zaffran, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1710 · Cited by 1,204
Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L., & Harvey, R. P. (1995) · Genes & Development · doi:10.1101/gad.9.13.1654 · Cited by 1,141
Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C
Lin, Q., Schwarz, J., Bucana, C., & N. Olson, E. (1997) · Science · doi:10.1126/science.276.5317.1404 · Cited by 1,055
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,041
Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., van de Wetering, M., Clevers, H., Schlag, P. M., Birchmeier, W., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1184-1193.2002 · Cited by 1,036
Self-citation
Cited by
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
Self-citationKattman, S. J., Witty, A. D., Gagliardi, M., Dubois, N. C., Niapour, M., Hotta, A., Ellis, J., & Keller, G. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.12.008 · Cited by 1,159
Grigoryan, T., Wend, P., Klaus, A., & Birchmeier, W. (2008) · Genes & Development · doi:10.1101/gad.1686208 · Cited by 560
Self-citationHuman heart-forming organoids recapitulate early heart and foregut development
Drakhlis, L., Biswanath, S., Farr, C.-M., Lupanow, V., Teske, J., Ritzenhoff, K., Franke, A., Manstein, F., Bolesani, E., Kempf, H., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00815-9 · Cited by 452
The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development
Gessert, S., & Kühl, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.221531 · Cited by 414
Metadata
- Authors
- Klaus, A., Saga, Y., Taketo, M. M., Tzahor, E., & Birchmeier, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-11-20
- Volume
- 104
- Issue
- 47
- Pages
- 18531-18536
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2025860724
- Cited by
- 278
- References
- 52
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis. https://app.cochat.ai/papers/10.1073/pnas.0703113104
- The paper
- Klaus, A., Saga, Y., Taketo, M. M., Tzahor, E., & Birchmeier, W. (2007). Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0703113104
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
