The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450
Open accessAbstract
How polyphagous herbivores cope with the diversity and unpredictability of plant defenses remains largely unknown at both the genetic and molecular levels. To examine whether generalist counterdefense enzymes are structurally more flexible and functionally more diverse, two counterdefensive allelochemical-metabolizing cytochrome P450 proteins, CYP6B1 from the specialist Papilio polyxenes , feeding on furanocoumarin-containing plants, and CYP6B8 from the generalist Helicoverpa zea , feeding on hundreds of host plant species, are compared structurally and functionally. Molecular modeling indicates that CYP6B8 has more flexible overall folding, a more elastic catalytic pocket, and one more substrate access channel than CYP6B1. Baculovirus-mediated expression of the CYP6B8 and CYP6B1 proteins demonstrates that CYP6B8 metabolizes six biosynthetically diverse plant allelochemicals (xanthotoxin, quercetin, flavone, chlorogenic acid, indole-3-carbinol, and rutin) and three insecticides (diazinon, cypermethrin, and aldrin), whereas CYP6B1 metabolizes only two allelochemicals (xanthotoxin and flavone) and one insecticide (diazinon) of those tested. These results indicate that generalist counterdefense proteins are capable of accepting a more structurally diverse array of compounds compared with specialist counterdefense proteins.
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Cites
All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins
MacKerell, A. D., Bashford, D., Bellott, M., Dunbrack, R. L., Evanseck, J. D., Field, M. J., Fischer, S., Gao, J., Guo, H., Ha, S., et al. (1998) · The Journal of Physical Chemistry B · doi:10.1021/jp973084f · Cited by 14,311
The Carbon Monoxide-binding Pigment of Liver Microsomes
Omura, T., & Sato, R. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82245-5 · Cited by 3,489
Host-Plant Selection by Phytophagous Insects
Bernays, E. A., & Chapman, R. E. (1994) · Springer eBooks · doi:10.1007/b102508 · Cited by 1,513
Host-plant selection by phytophagous insects
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3872 · Cited by 1,411
High-resolution crystal structure of cytochrome P450cam
Poulos, T. L., Finzel, B. C., & Howard, A. J. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90190-2 · Cited by 1,411
The Ecology of Heliothis Species in Relation to Agroecosystems
Fitt, G. P. (1989) · Annual Review of Entomology · doi:10.1146/annurev.en.34.010189.000313 · Cited by 993
Plant resistance towards insect herbivores: a dynamic interaction
Gatehouse, J. A. (2002) · New Phytologist · doi:10.1046/j.1469-8137.2002.00519.x · Cited by 704
Bernays, E. A. (2001) · Annual Review of Entomology · doi:10.1146/annurev.ento.46.1.703 · Cited by 480
Lüdemann, S. K., Lounnas, V., & Wade, R. C. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4154 · Cited by 326
Jasmonate and salicylate induce expression of herbivore cytochrome P450 genes
Li, X., Schuler, M. A., & Berenbaum, M. R. (2002) · Nature · doi:10.1038/nature01003 · Cited by 263
Self-citation
Cited by
Molecular Mechanisms of Metabolic Resistance to Synthetic and Natural Xenobiotics
Li, X., Schuler, M. A., & Berenbaum, M. R. (2007) · Annual Review of Entomology · doi:10.1146/annurev.ento.51.110104.151104 · Cited by 2,109
Self-citationNkya, T. E., Akhouayri, I., Kisinza, W., & David, J.-P. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2012.10.006 · Cited by 402
Characterization of Drosophila melanogaster cytochrome P450 genes
Chung, H., Sztal, T., Pasricha, S., Sridhar, M., Batterham, P., & Daborn, P. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812141106 · Cited by 310
Plant–arthropod interactions: who is the winner?
Stahl, E., Hilfiker, O., & Reymond, P. (2018) · The Plant Journal · doi:10.1111/tpj.13773 · Cited by 164
Avoidance and suppression of plant defenses by herbivores and pathogens
Alba, J. M., Glas, J. J., Schimmel, B. C. J., & Kant, M. R. (2011) · Journal of Plant Interactions · doi:10.1080/17429145.2010.551670 · Cited by 76
Metadata
- Authors
- Li, X., Baudry, J., Berenbaum, M. R., & Schuler, M. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-02-23
- Volume
- 101
- Issue
- 9
- Pages
- 2939-2944
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137572691
- Cited by
- 299
- References
- 24
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, X., Baudry, J., Berenbaum, M. R., & Schuler, M. A. (2004). Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0308691101
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