The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Molecular Mechanisms of Metabolic Resistance to Synthetic and Natural Xenobiotics
Abstract
Xenobiotic resistance in insects has evolved predominantly by increasing the metabolic capability of detoxificative systems and/or reducing xenobiotic target site sensitivity. In contrast to the limited range of nucleotide changes that lead to target site insensitivity, many molecular mechanisms lead to enhancements in xenobiotic metabolism. The genomic changes that lead to amplification, overexpression, and coding sequence variation in the three major groups of genes encoding metabolic enzymes, i.e., cytochrome P450 monooxygenases (P450s), esterases, and glutathione-S-transferases (GSTs), are the focus of this review. A substantial number of the adaptive genomic changes associated with insecticide resistance that have been characterized to date are transposon mediated. Several lines of evidence suggest that P450 genes involved in insecticide resistance, and perhaps insecticide detoxification genes in general, may share an evolutionary association with genes involved in allelochemical metabolism. Differences in the selective regime imposed by allelochemicals and insecticides may account for the relative importance of regulatory or structural mutations in conferring resistance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The molecular basis of insecticide resistance in mosquitoes
Hemingway, J., Hawkes, N. J., McCarroll, L., & Ranson, H. (2004) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2004.03.018 · Cited by 1,109
Insect glutathione transferases and insecticide resistance
Enayati, A. A., Ranson, H., & Hemingway, J. (2005) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2004.00529.x · Cited by 1,084
A Single P450 Allele Associated with Insecticide Resistance in Drosophila
Daborn, P. J., Yen, J. L., Bogwitz, M. R., Le Goff, G., Feil, E., Jeffers, S., Tijet, N., Perry, T., Heckel, D., Batterham, P., et al. (2002) · Science · doi:10.1126/science.1074170 · Cited by 849
Claudianos, C., Ranson, H., Johnson, R. M., Biswas, S., Schuler, M. A., Berenbaum, M. R., Feyereisen, R., & Oakeshott, J. G. (2006) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2006.00672.x · Cited by 786
Self-citationCytochromes P450 and insecticide resistance
Scott, J. G. (1999) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(99)00038-7 · Cited by 775
Evolution of Supergene Families Associated with Insecticide Resistance
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J., Sharakhova, M. V., Unger, M. F., Collins, F. H., & Feyereisen, R. (2002) · Science · doi:10.1126/science.1076781 · Cited by 666
Identification of a Gene Associated with Bt Resistance in Heliothis virescens
Gahan, L. J., Gould, F., & Heckel, D. G. (2001) · Science · doi:10.1126/science.1060949 · Cited by 610
VONTAS, J. G., SMALL, G. J., & HEMINGWAY, J. (2001) · Biochemical Journal · doi:10.1042/bj3570065 · Cited by 583
Ranson, H., Rossiter, L. C., Ortelli, F., Jensen, B., Wang, X., Roth, C. W., Collins, F. H., & Hemingway, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590295 · Cited by 437
Feyereisen, R. (2005) · Comprehensive Molecular Insect Science · doi:10.1016/b0-44-451924-6/00049-1 · Cited by 420
Cited by
Nkya, T. E., Akhouayri, I., Kisinza, W., & David, J.-P. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2012.10.006 · Cited by 402
Characterization of Drosophila melanogaster cytochrome P450 genes
Chung, H., Sztal, T., Pasricha, S., Sridhar, M., Batterham, P., & Daborn, P. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812141106 · Cited by 310
Comparative analysis of detoxification enzymes in Acyrthosiphon pisum and Myzus persicae
Ramsey, J. S., Rider, D. S., Walsh, T. K., De Vos, M., Gordon, K. H. J., Ponnala, L., Macmil, S. L., Roe, B. A., & Jander, G. (2010) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2009.00973.x · Cited by 253
Barakat, A., DiLoreto, D. S., Zhang, Y., Smith, C., Baier, K., Powell, W. A., Wheeler, N., Sederoff, R., & Carlson, J. E. (2009) · BMC Plant Biology · doi:10.1186/1471-2229-9-51 · Cited by 243
Plant–arthropod interactions: who is the winner?
Stahl, E., Hilfiker, O., & Reymond, P. (2018) · The Plant Journal · doi:10.1111/tpj.13773 · Cited by 164
Metadata
- Authors
- Li, X., Schuler, M. A., & Berenbaum, M. R.
- Venue
- Annual Review of Entomology
- Publisher
- Annual Reviews
- Published
- 2007-01-01
- Volume
- 52
- Issue
- 1
- Pages
- 231-253
- ISSN
- 0066-4170 (ISSN-L)
- 1545-4487
- OpenAlex
- W2098086227
- Cited by
- 2,109
- References
- 100
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Molecular Mechanisms of Metabolic Resistance to Synthetic and Natural Xenobiotics. https://app.cochat.ai/papers/10.1146/annurev.ento.51.110104.151104
- The paper
- Li, X., Schuler, M. A., & Berenbaum, M. R. (2007). Molecular Mechanisms of Metabolic Resistance to Synthetic and Natural Xenobiotics. Annual Review of Entomology. https://doi.org/10.1146/annurev.ento.51.110104.151104
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
