The DOI matches its Crossref record.
Heteromultimers of DEG/ENaC subunits form H + -gated channels in mouse sensory neurons
Open accessAbstract
Acidic extracellular solution activates transient H + -gated currents in dorsal root ganglion (DRG) neurons. The biophysical properties of three degenerin/epithelial sodium (DEG/ENaC) channel subunits (BNC1, ASIC, and DRASIC), and their expression in DRG, suggest that they might underlie these H + -gated currents and function as sensory transducers. However, it is uncertain which of these DEG/ENaC subunits generate the currents, and whether they function as homomultimers or heteromultimers. We found that the biophysical properties of transient H + -gated currents from medium to large mouse DRG neurons differed from BNC1, ASIC, or DRASIC expressed individually, but were reproduced by coexpression of the subunits together. To test the contribution of each subunit, we studied DRG from three strains of mice, each bearing a targeted disruption of BNC1, ASIC, or DRASIC. Deletion of any one subunit did not abolish H + -gated currents, but altered currents in a manner consistent with heteromultimerization of the two remaining subunits. These data indicate that combinations of two or more DEG/ENaC subunits coassemble as heteromultimers to generate transient H + -gated currents in mouse DRG neurons.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH
Jasti, J., Furukawa, H., Gonzales, E. B., & Gouaux, E. (2007) · Nature · doi:10.1038/nature06163 · Cited by 1,043
The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory
Wemmie, J. A., Chen, J., Askwith, C. C., Hruska-Hageman, A. M., Price, M. P., Nolan, B. C., Yoder, P. G., Lamani, E., Hoshi, T., Freeman, J. H., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00661-x · Cited by 657
Self-citationAcid-sensing ion channels: advances, questions and therapeutic opportunities
Wemmie, J. A., Price, M. P., & Welsh, M. J. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.06.014 · Cited by 559
Self-citationThe Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior
Ziemann, A. E., Allen, J. E., Dahdaleh, N. S., Drebot, I. I., Coryell, M. W., Wunsch, A. M., Lynch, C. M., Faraci, F. M., Howard, M. A., Welsh, M. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.029 · Cited by 434
Self-citationWemmie, J. A., Askwith, C. C., Lamani, E., Cassell, M. D., Freeman, J. H., & Welsh, M. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05496.2003 · Cited by 428
Self-citation
Metadata
- Authors
- Benson, C. J., Xie, J., Wemmie, J. A., Price, M. P., Henss, J. M., Welsh, M. J., & Snyder, P. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-02-19
- Volume
- 99
- Issue
- 4
- Pages
- 2338-2343
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1991705866
- Cited by
- 354
- References
- 0
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Heteromultimers of DEG/ENaC subunits form H + -gated channels in mouse sensory neurons. https://app.cochat.ai/papers/10.1073/pnas.032678399
- The paper
- Benson, C. J., Xie, J., Wemmie, J. A., Price, M. P., Henss, J. M., Welsh, M. J., & Snyder, P. M. (2002). Heteromultimers of DEG/ENaC subunits form H + -gated channels in mouse sensory neurons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.032678399
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
