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Cited by 196

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment

Open access
Wood, Gwendolyn E., Young, L. Trevor, Reagan, Lawrence P., Chen, Biao, McEwen, Bruce S.·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0400208101
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Abstract

Chronic restraint stress, psychosocial stress, as well as systemic or oral administration of the stress-hormone corticosterone induces a morphological reorganization in the rat hippocampus, in which adrenal steroids and excitatory amino acids mediate a reversible remodeling of apical dendrites on CA3 pyramidal cell neurons of the hippocampus. This stress-induced neuronal remodeling is accompanied also by behavioral changes, some of which can be prevented with selective antidepressant and anticonvulsive drug treatments. Lithium is an effective treatment for mood disorders and has neuroprotective effects, which may contribute to its therapeutic properties. Thus, we wanted to determine whether lithium treatment could prevent the effects of chronic stress on CA3 pyramidal cell neuroarchitecture and the associated molecular and behavioral measures. Chronic lithium treatment prevented the stress-induced decrease in dendritic length, as well as the stress-induced increase in glial glutamate transporter 1 (GLT-1) mRNA expression and the phosphorylation of cAMP-response element binding in the hippocampus. Lithium treatment, however, did not prevent stress effects on behavior in the open field or the plus-maze. These data demonstrate that chronic treatment with lithium can protect the hippocampus from potentially deleterious effects of chronic stress on glutamatergic activation, which may be relevant to its therapeutic efficacy in the treatment of major depressive disorder and bipolar disorder.

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Metadata

Authors
Wood, G. E., Young, L. T., Reagan, L. P., Chen, B., & McEwen, B. S.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2004-03-04
Volume
101
Issue
11
Pages
3973-3978
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0400208101
OpenAlex
W2029406839
Cited by
196
References
13
FWCI
6.14
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment. https://app.cochat.ai/papers/10.1073/pnas.0400208101
The paper
Wood, G. E., Young, L. T., Reagan, L. P., Chen, B., & McEwen, B. S. (2004). Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0400208101

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.