The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
Open accessAbstract
Longevity regulatory genes include the Forkhead transcription factor FOXO and the NAD-dependent histone deacetylase silent information regulator 2 (Sir2). Genetic studies demonstrate that Sir2 acts to extend lifespan in Caenorhabditis elegans upstream of DAF-16, a member of the FOXO family, in the insulin-like signaling pathway. However, the molecular mechanisms underlying the requirement of DAF-16 activity in Sir2-mediated longevity remain unknown. Here we show that reversible acetylation of Foxo1 (also known as FKHR), the mouse DAF-16 ortholog, modulates its transactivation function. cAMP-response element-binding protein (CREB)-binding protein binds and acetylates Foxo1 at the K242, K245, and K262 residues, the modification of which is involved in the attenuation of Foxo1 as a transcription factor. Conversely, Sir2 binds and deacetylates Foxo1 at residues acetylated by cAMP-response element-binding protein-binding protein. Sir2 is recruited to insulin response sequence-containing promoter and increases the expression of manganese superoxide dismutase and p27 kip1 in a deacetylase-activity-dependent manner. Our findings establish Foxo1 as a direct and functional target for Sir2 in mammalian systems.
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Cites
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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
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Cited by
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
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SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
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Epigenetic mechanisms of longevity and aging
Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956
Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881
Metadata
- Authors
- Daitoku, H., Hatta, M., Matsuzaki, H., Aratani, S., Ohshima, T., Miyagishi, M., Nakajima, T., & Fukamizu, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-06-25
- Volume
- 101
- Issue
- 27
- Pages
- 10042-10047
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977351943
- Cited by
- 602
- References
- 11
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- green
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