Epigenetic mechanisms of longevity and aging

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339 · see citing works

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075 · see citing works

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · see citing works

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works

Genome-wide methylation profiles reveal quantitative views of human aging rates

Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works

Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,262 · see citing works

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239 · see citing works

The genetics of ageing

Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works

The role of senescent cells in ageing

van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · see citing works

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

McCay, C. M., Crowell, M. F., & Maynard, L. A. (1935) · The Journal of Nutrition · doi:10.1093/jn/10.1.63 · Cited by 2,264 · see citing works

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · see citing works

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J. I., Scott, L. J., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003) · Nature · doi:10.1038/nature01629 · Cited by 2,217 · see citing works

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935 · see citing works

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868 · see citing works

Cellular and molecular mechanisms of metformin: an overview

Viollet, B., Guigas, B., Garcia, N. S., Leclerc, J., Foretz, M., & Andreelli, F. (2012) · Clinical Science · doi:10.1042/cs20110386 · Cited by 1,720 · see citing works

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works

Induction of autophagy by spermidine promotes longevity

Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680 · see citing works

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630 · see citing works

Extrachromosomal rDNA circles—a cause of aging in yeast

Sinclair, D. A., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80493-6 · Cited by 1,500 · see citing works

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,496 · see citing works

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works

Lamin A Truncation in Hutchinson-Gilford Progeria

Sandre‐Giovannoli, A. D., Bernard, R., Cau, P., Navarro, C. L., Amiel, J., Boccaccio, I., Lyonnet, S., Stewart, C. L., Münnich, A., Merrer, M. F. L., et al. (2003) · Science · doi:10.1126/science.1084125 · Cited by 1,472 · see citing works

Metformin improves healthspan and lifespan in mice

Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436 · see citing works

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361 · see citing works

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293 · see citing works

NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · see citing works

Lamin A-Dependent Nuclear Defects in Human Aging

Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,224 · see citing works

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome

Goldman, R. D., Shumaker, D. K., Erdos, M. R., Eriksson, M., Goldman, A. E., Gordon, L. B., Gruenbaum, Y., Khuon, S., Mendez, M., Varga, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402943101 · Cited by 1,103 · see citing works

Cellular Senescence in Aging Primates

Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101 · see citing works

The role of mitochondria in aging

Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087 · see citing works

The sirtuin SIRT6 regulates lifespan in male mice

Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059 · see citing works

Lamin B1 loss is a senescence-associated biomarker

Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046 · see citing works

Mitonuclear protein imbalance as a conserved longevity mechanism

Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works

Calorie restriction, SIRT1 and metabolism: understanding longevity

Bordone, L., & Guarente, L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1616 · Cited by 1,021 · see citing works

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

Friedman, D. B., & Johnson, T. E. (1988) · Genetics · doi:10.1093/genetics/118.1.75 · Cited by 1,011 · see citing works

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatinPreprint

Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 1,001 · see citing works

Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling

Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development · doi:10.1101/gad.1381406 · Cited by 982 · see citing works

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

Loewith, R., & Hall, M. N. (2011) · Genetics · doi:10.1534/genetics.111.133363 · Cited by 900 · see citing works

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

Hansen, M., Taubert, S., Crawford, D. K., Libina, N., Lee, S., & Kenyon, C. J. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00267.x · Cited by 877 · see citing works

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001) · Science · doi:10.1126/science.1059497 · Cited by 874 · see citing works

The Polycomb group proteins bind throughout the <i>INK4A-ARF</i> locus and are disassociated in senescent cells

Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes &amp; Development · doi:10.1101/gad.415507 · Cited by 850 · see citing works

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826 · see citing works

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

Zhou, Y., Xu, B. C., Maheshwari, H., He, L., Reed, M. A., Lozykowski, M. G., Okada, S., Cataldo, L. R., Coschigamo, K., Wagner, T. E., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13215 · Cited by 802 · see citing works

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801 · see citing works

Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

Chambers, S. M., Shaw, C. A., Gatza, C. E., Fisk, C. J., Donehower, L. A., & Goodell, M. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050201 · Cited by 799 · see citing works

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791 · see citing works

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

Weindruch, R. H., & Walford, R. L. (1982) · Science · doi:10.1126/science.7063854 · Cited by 766 · see citing works

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

Merideth, M. A., Gordon, L. B., Clauss, S. B., Sachdev, V., Smith, A. C. M., Perry, M. B., Brewer, C. C., Zalewski, C. K., Kim, H. J., Solomon, B. I., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706898 · Cited by 740 · see citing works

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

Satoh, A., Brace, C. S., Rensing, N., Cliften, P. F., Wozniak, D. F., Herzog, E. D., Yamada, K. A., & Imai, S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.013 · Cited by 734 · see citing works

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731 · see citing works

DNA Methylation on N6-Adenine in C. elegans

Greer, E. L., Blanco, M. A., Gu, L., Sendinc, E., Liu, J., Aristizábal-Corrales, D., Hsu, C.-H., Aravind, L., He, C., & Shi, Y. (2015) · Cell · doi:10.1016/j.cell.2015.04.005 · Cited by 702 · see citing works

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

Sun, D., Luo, M., Jeong, M., Rodriguez, B., Xia, Z., Hannah, R., Wang, H., Le, T., Faull, K. F., Chen, R., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.03.002 · Cited by 686 · see citing works

The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.

Cm, M., Crowell, M. F., & MAYNARD, L. A. (1989) · PubMed · Cited by 670 · see citing works

Histone H4 lysine 16 acetylation regulates cellular lifespan

Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667 · see citing works

Autophagy mediates degradation of nuclear lamina

Dou, Z., Xu, C., Donahue, G., Shimi, T., Pan, J.-A., Zhu, J., Ivanov, A., Capell, B. C., Drake, A. M., Shah, P. P., et al. (2015) · Nature · doi:10.1038/nature15548 · Cited by 655 · see citing works

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

Grönke, S., Clarke, D.-F., Broughton, S. J., Andrews, T. D., & Partridge, L. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000857 · Cited by 651 · see citing works

N6-Methyladenine DNA Modification in Drosophila

Zhang, G., Huang, H., Liu, D., Cheng, Y., Liu, X., Zhang, W., Yin, R., Zhang, D., Zhang, P., Liu, J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.018 · Cited by 637 · see citing works

Sirtuins in aging and age-related disease

Longo, V. D., & Kennedy, B. K. (2006) · Cell · doi:10.1016/j.cell.2006.07.002 · Cited by 628 · see citing works

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

Scaffidi, P., & Misteli, T. (2005) · Nature Medicine · doi:10.1038/nm1204 · Cited by 619 · see citing works

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

Herranz, D., Muñoz-Martin, M., Cañamero, M., Mulero, F., Martinez-Pastor, B., Fernandez-Capetillo, O., & Serrano, M. (2010) · Nature Communications · doi:10.1038/ncomms1001 · Cited by 612 · see citing works

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610 · see citing works

Human longevity at the cost of reproductive success

Westendorp, R. G. J., & Kirkwood, T. B. L. (1998) · Nature · doi:10.1038/25519 · Cited by 607 · see citing works

Increased cell-to-cell variation in gene expression in ageing mouse heart

Bahar, R., Hartmann, C. H., Rodriguez, K. A., Denny, A. D., Busuttil, R. A., Dollé, M. E. T., Calder, R. B., Chisholm, G. B., Pollock, B. H., Klein, C. A., et al. (2006) · Nature · doi:10.1038/nature04844 · Cited by 603 · see citing works

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

Daitoku, H., Hatta, M., Matsuzaki, H., Aratani, S., Ohshima, T., Miyagishi, M., Nakajima, T., & Fukamizu, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400593101 · Cited by 602 · see citing works

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice

Pendás, A. M., Zhou, Z., Cadiñanos, J., Freije, J. M. P., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodríguez, F., Tryggvason, K., et al. (2002) · Nature Genetics · doi:10.1038/ng871 · Cited by 554 · see citing works

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

Shah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., et al. (2013) · Genes &amp; Development · doi:10.1101/gad.223834.113 · Cited by 550 · see citing works

The role of nuclear lamin B1 in cell proliferation and senescence

Shimi, T., Butin-Israeli, V., Adam, S. A., Hamanaka, R. B., Goldman, A. E., Lucas, C. A., Shumaker, D. K., Kosak, S. T., Chandel, N. S., & Goldman, R. D. (2011) · Genes &amp; Development · doi:10.1101/gad.179515.111 · Cited by 547 · see citing works

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature · doi:10.1038/nature09195 · Cited by 543 · see citing works

Lysosome-mediated processing of chromatin in senescence

Ivanov, A., Pawlikowski, J., Manoharan, I., van Tuyn, J., Nelson, D. M., Rai, T. S., Shah, P. P., Hewitt, G., Korolchuk, V. I., Passos, J. F., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201212110 · Cited by 539 · see citing works

Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes

Frescas, D., Valenti, L. V. C., & Accili, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412357200 · Cited by 528 · see citing works

A systematic RNAi screen for longevity genes in C. elegansPreprint

Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G., & Lee, S. S. (2005) · Genes & Development · doi:10.1101/gad.1308205 · Cited by 513 · see citing works

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

Kennedy, B. K., Austriaco, N. P. G., Zhang, J., & Guarente, L. (1995) · Cell · doi:10.1016/0092-8674(95)90499-9 · Cited by 499 · see citing works

The Aging Epigenome

Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499 · see citing works

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect

Bergö, M. O., Gavino, B. J., Ross, J., Schmidt, W. K., Hong, C., Kendall, L. V., Mohr, A., Meta, M. D., Genant, H. K., Jiang, Y., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192460799 · Cited by 443 · see citing works

Yeast Rtt109 Promotes Genome Stability by Acetylating Histone H3 on Lysine 56

Driscoll, R., Hudson, A., & Jackson, S. P. (2007) · Science · doi:10.1126/science.1135862 · Cited by 439 · see citing works

Elevated histone expression promotes life span extension

Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.015 · Cited by 435 · see citing works

Rtt109 Acetylates Histone H3 Lysine 56 and Functions in DNA Replication

Han, J., Zhou, H., Horazdovsky, B. F., Zhang, K., Xu, R.-M., & Zhang, Z. (2007) · Science · doi:10.1126/science.1133234 · Cited by 421 · see citing works

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

O'Sullivan, R. J., Kubicek, S., Schreiber, S. L., & Karlseder, J. (2010) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.1897 · Cited by 416 · see citing works

Molecular dissection of formation of senescence-associated heterochromatin foci

Zhang, R., Chen, W., & Adams, P. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02019-06 · Cited by 415 · see citing works

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

Mitchell, S. J., Martín‐Montalvo, A., Mercken, E. M., Palacios, H. H., Ward, T. M., Abulwerdi, G. A., Minor, R. K., Vlasuk, G. P., Ellis, J. L., Sinclair, D. A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.031 · Cited by 399 · see citing works

Progeria syndromes and ageing: what is the connection?

Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386 · see citing works

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

Di Micco, R., Sulli, G., Dobreva, M., Liontos, M., Botrugno, O. A., Gargiulo, G., dal Zuffo, R., Matti, V., d'Ario, G., Montani, E., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2170 · Cited by 382 · see citing works

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

De Cecco, M., Criscione, S. W., Peterson, A. L., Neretti, N., Sedivy, J. M., & Kreiling, J. A. (2013) · Aging · doi:10.18632/aging.100621 · Cited by 365 · see citing works

Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

Day, K. R., Waite, L. L., Thalacker‐Mercer, A. E., West, A. B., Bamman, M. M., Brooks, J. D., Myers, R., & Absher, D. (2013) · Genome biology · doi:10.1186/gb-2013-14-9-r102 · Cited by 363 · see citing works

Senescent cells harbour features of the cancer epigenome

Cruickshanks, H. A., McBryan, T., Nelson, D. M., VanderKraats, N. D., Shah, P. P., van Tuyn, J., Singh Rai, T., Brock, C., Donahue, G., Dunican, D. S., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2879 · Cited by 358 · see citing works

Life Extension in the Dwarf Mouse

Bartke, A., & Brown‐Borg, H. M. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)63006-7 · Cited by 354 · see citing works

SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast

Fabrizio, P., Liou, L.-L., Moy, V. N., Diaspro, A., Valentine, J. S., Gralla, E. B., & Longo, V. D. (2003) · Genetics · doi:10.1093/genetics/163.1.35 · Cited by 335 · see citing works

Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast agingPreprint

Hu, Z., Chen, K., Xia, Z., Chavez-Tomar, M., Pal, S., Seol, J.-H., Chen, C., Li, W., & Tyler, J. K. (2014) · Genes & Development · doi:10.1101/gad.233221.113 · Cited by 330 · see citing works

Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

Adams, P. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.021 · Cited by 326 · see citing works

Correlated alterations in genome organization, histone methylation, and DNA–lamin A/C interactions in Hutchinson-Gilford progeria syndromePreprint

McCord, R. P., Nazario-Toole, A., Zhang, H., Chines, P. S., Zhan, Y., Erdos, M. R., Collins, F. S., Dekker, J., & Cao, K. (2012) · Genome Research · doi:10.1101/gr.138032.112 · Cited by 326 · see citing works

Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming

Du, Y., Wang, J., Jia, J., Song, N., Xiang, C., Xu, J., Hou, Z., Su, X., Liu, B., Jiang, T., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.01.008 · Cited by 320 · see citing works

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

Partridge, L., Alic, N., Bjedov, I., & Piper, M. D. W. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.003 · Cited by 313 · see citing works

Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae

Smeal, T., Claus, J., Kennedy, B., Cole, F., & Guarente, L. (1996) · Cell · doi:10.1016/s0092-8674(00)81038-7 · Cited by 308 · see citing works

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

Chandra, T., Kirschner, K., Thuret, J.-Y., Pope, B. D., Ryba, T., Newman, S., Ahmed, K., Samarajiwa, S. A., Salama, R., Carroll, T., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.010 · Cited by 308 · see citing works

Werner and Hutchinson–Gilford progeria syndromes: mechanistic basis of human progeroid diseases

Kudlow, B. A., Kennedy, B. K., & Monnat, R. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2161 · Cited by 304 · see citing works

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works

Ageing-related chromatin defects through loss of the NURD complex

Pegoraro, G., Kubben, N., Wickert, U., Goehler, H., Hoffmann, K., & Misteli, T. (2009) · Nature Cell Biology · doi:10.1038/ncb1971 · Cited by 293 · see citing works

Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction

Rogina, B., Helfand, S. L., & Frankel, S. A. (2002) · Science · doi:10.1126/science.1078986 · Cited by 276 · see citing works

Temporal linkage between the phenotypic and genomic responses to caloric restriction

Dhahbi, J. M., Kim, H.-J., Mote, P. L., Beaver, R. J., & Spindler, S. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305300101 · Cited by 259 · see citing works

Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway

Jin, C., Li, J., Green, C. D., Yu, X., Tang, X., Han, D., Xian, B., Wang, D., Huang, X., Cao, X., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.001 · Cited by 258 · see citing works

The H3K27 demethylase UTX‐1 regulates <i>C. elegans</i> lifespan in a germline‐independent, insulin‐dependent manner

Maures, T. J., Greer, E. L., Hauswirth, A. G., & Brunet, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00738.x · Cited by 256 · see citing works

Postsynthetic Trimethylation of Histone H4 at Lysine 20 in Mammalian Tissues Is Associated with Aging

Sarg, B., Koutzamani, E., Helliger, W., Rundquist, I., & Lindner, H. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205166200 · Cited by 252 · see citing works

Cytosine DNA Methylation Is Found in Drosophila melanogaster but Absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Other Yeast Species

Capuano, F., Mülleder, M., Kok, R., Blom, H. J., & Ralser, M. (2014) · Analytical Chemistry · doi:10.1021/ac500447w · Cited by 250 · see citing works

Inherited Ateliotic Dwarfism in Mice: Characteristics of the mutation, little, on Chromosome 6

Eicher, E. M., & Beamer, W. G. (1976) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a108682 · Cited by 247 · see citing works

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

McCormick, M. A., Delaney, J. R., Tsuchiya, M., Tsuchiyama, S. K., Shemorry, A., Sim, S., Chou, A., Ahmed, U., Carr, D. T., Murakami, C. J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.008 · Cited by 246 · see citing works

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michán, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201386907 · Cited by 243 · see citing works

Epigenetic (re)programming of caste-specific behavior in the ant <i>Camponotus floridanus</i>

Simola, D. F., Graham, R. J., Brady, C. M., Enzmann, B. L., Desplan, C., Ray, A., Zwiebel, L. J., Bonasio, R., Reinberg, D., Liebig, J., et al. (2016) · Science · doi:10.1126/science.aac6633 · Cited by 242 · see citing works

Recent developments in yeast aging

Kaeberlein, M., Burtner, C. R., & Kennedy, B. K. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030084 · Cited by 239 · see citing works

Drosophila melanogaster in the Study of Human Neurodegeneration

Hirth, F. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791556104 · Cited by 236 · see citing works

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

Sen, P., Dang, W., Donahue, G., Dai, J., Dorsey, J., Cao, X., Liu, W., Cao, K., Perry, R., Lee, J. Y., et al. (2015) · Genes &amp; Development · doi:10.1101/gad.263707.115 · Cited by 233 · see citing works

A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate

Harel, I., Benayoun, B. A., Machado, B., Singh, P. P., Hu, C.-K., Pech, M. F., Valenzano, D. R., Zhang, E., Sharp, S. C., Artandi, S. E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.038 · Cited by 232 · see citing works

Probing Nucleosome Function: A Highly Versatile Library of Synthetic Histone H3 and H4 Mutants

Dai, J., Hyland, E. M., Yuan, D., Huang, H., Bader, J. S., & Boeke, J. D. (2008) · Cell · doi:10.1016/j.cell.2008.07.019 · Cited by 229 · see citing works

Polycomb Repressive Complex 2 and Trithorax modulate <i>Drosophila</i> longevity and stress resistance

Siebold, A. P., Banerjee, R., Tie, F., Kiss, D. L., Moskowitz, J., & Harte, P. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907739107 · Cited by 216 · see citing works

Erratum to: DNA methylation age of human tissues and cell types

Horvath, S. (2015) · Genome biology · doi:10.1186/s13059-015-0649-6 · Cited by 216 · see citing works

Saccharomyces cerevisiae Ras/cAMP pathway controls post‐diauxic shift element‐dependent transcription through the zinc finger protein Gis1

Pedruzzi, I., Bürckert, N., Egger, P., & Virgilio, C. D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.11.2569 · Cited by 212 · see citing works

Modulation of Life-span by Histone Deacetylase Genes inSaccharomyces cerevisiae

Kim, S., Benguría, A., Lai, C.-Y., & Jazwinski, S. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3125 · Cited by 212 · see citing works

Regulating the Chromatin Landscape: Structural and Mechanistic Perspectives

Bartholomew, B. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051810-093157 · Cited by 210 · see citing works

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity

Riedel, C. G., Dowen, R. H., Lourenco, G. F., Kirienko, N. V., Heimbucher, T., West, J. A., Bowman, S. K., Kingston, R. E., Dillin, A., Asara, J. M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2720 · Cited by 207 · see citing works

Histone methylation makes its mark on longevity

Han, S., & Brunet, A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.11.001 · Cited by 204 · see citing works

Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans

McColl, G., Killilea, D. W., Hubbard, A. E., Vantipalli, M. C., Melov, S., & Lithgow, G. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705028200 · Cited by 202 · see citing works

Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways

Chen, Y., Zhao, W., Yang, J. S., Cheng, Z., Luo, H., Lu, Z., Tan, M., Gu, W. J., & Zhao, Y. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.019547 · Cited by 202 · see citing works

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation

Nakanishi, S., Sanderson, B. W., Delventhal, K. M., Bradford, W. D., Staehling‐Hampton, K., & Shilatifard, A. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1454 · Cited by 201 · see citing works

Chromatin remodeling in the aging genome of Drosophila

Wood, J. G., Hillenmeyer, S., Lawrence, C., Chang, C., Hosier, S., Lightfoot, W., Mukherjee, E., Jiang, N., Schorl, C., Brodsky, A. S., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00624.x · Cited by 192 · see citing works

Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24

Corrigan, D. P., Kuszczak, D., Rusiñol, A. E., Thewke, D. P., Hrycyna, C. A., Michaelis, S., & Sinensky, M. S. (2005) · Biochemical Journal · doi:10.1042/bj20041359 · Cited by 187 · see citing works

Epigenetic silencing mediates mitochondria stress-induced longevity

Schroeder, E. A., Raimundo, N., & Shadel, G. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.003 · Cited by 186 · see citing works

Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats

Oakes, C. C., Smiraglia, D. J., Plass, C., Trasler, J. M., & Robaire, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437971100 · Cited by 184 · see citing works

<scp>RNA</scp> ‐seq of the aging brain in the short‐lived fish <i>N. furzeri</i> – conserved pathways and novel genes associated with neurogenesis

Baumgart, M., Groth, M., Priebe, S., Savino, A., Testa, G., Dix, A., Ripa, R., Spallotta, F., Gaetano, C., Ori, M., et al. (2014) · Aging Cell · doi:10.1111/acel.12257 · Cited by 167 · see citing works

High Basal Metabolic Rate Is a Risk Factor for Mortality: The Baltimore Longitudinal Study of Aging

Ruggiero, C., Metter, E. J., Melenovský, V., Cherubini, A., Najjar, S. S., Blè, A., Senin, U., Longo, D. L., & Ferrucci, L. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.7.698 · Cited by 164 · see citing works

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

Rai, T. S., Cole, J. J., Nelson, D. M., Dikovskaya, D., Faller, W. J., Vizioli, M. G., Hewitt, R. N., Anannya, O., McBryan, T., Manoharan, I., et al. (2014) · Genes &amp; Development · doi:10.1101/gad.247528.114 · Cited by 162 · see citing works

The Tor Pathway Regulates Gene Expression by Linking Nutrient Sensing to Histone Acetylation

Rohde, J. R., & Cardenas, M. E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.629-635.2003 · Cited by 159 · see citing works

DNA methylation in aging of mice

Singhal, R. P., Mays-Hoopes, L. L., & Eichhorn, G. L. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90040-6 · Cited by 156 · see citing works

MLL1 is essential for the senescence-associated secretory phenotype

Capell, B. C., Drake, A. M., Zhu, J., Shah, P. P., Dou, Z., Dorsey, J., Simola, D. F., Donahue, G., Sammons, M., Rai, T. S., et al. (2016) · Genes &amp; Development · doi:10.1101/gad.271882.115 · Cited by 156 · see citing works

Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans

Ni, Z., Ebata, A., Alipanahiramandi, E., & Lee, S. S. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00785.x · Cited by 154 · see citing works

Calorie restriction and the exercise of chromatinPreprint

Vaquero, A., & Reinberg, D. (2009) · Genes & Development · doi:10.1101/gad.1807009 · Cited by 154 · see citing works

Age‐associated increase in heterochromatic marks in murine and primate tissues

Kreiling, J. A., Tamamori‐Adachi, M., Sexton, A. N., Jeyapalan, J. C., Munoz‐Najar, U., Peterson, A. L., Manivannan, J., Rogers, E. S., Pchelintsev, N. A., Adams, P. D., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00666.x · Cited by 152 · see citing works

Essential Functions of the Histone Demethylase Lid

Li, L., Greer, C., Eisenman, R. N., & Secombe, J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001221 · Cited by 150 · see citing works

Single-cell sequencing

Nawy, T. (2013) · Nature Methods · doi:10.1038/nmeth.2771 · Cited by 148 · see citing works

If you would live long, choose your parents well

Cournil, A., & Kirkwood, T. B. L. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02306-x · Cited by 144 · see citing works

The Genome-Wide Localization of Rsc9, a Component of the RSC Chromatin-Remodeling Complex, Changes in Response to Stress

Damelin, M. I., Simon, I., Moy, T. I., Wilson, B. G., Komili, S., Tempst, P., Roth, F. P., Young, R. A., Cairns, B. R., & Silver, P. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00475-6 · Cited by 143 · see citing works

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila

Peleg, S., Feller, C., Forné, I., Schiller, E., Sévin, D. C., Schauer, T., Regnard, C., Straub, T., Prestel, M., Klima, C., et al. (2016) · EMBO Reports · doi:10.15252/embr.201541132 · Cited by 135 · see citing works

DNA Methyltransferase Gene dDnmt2 and Longevity of Drosophila

Lin, M.-J., Tang, L.-Y., Reddy, M. N., & Shen, C. ‐. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400477200 · Cited by 132 · see citing works

RLE-1, an E3 Ubiquitin Ligase, Regulates C. elegans Aging by Catalyzing DAF-16 Polyubiquitination

Li, W., Gao, B., Lee, S., Bennett, K. L., & Fang, D. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.12.002 · Cited by 130 · see citing works

Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex

Ricketts, M. D., Frederick, B. T., Hoff, H. B., Tang, Y., Schultz, D., Singh, T., Vizioli, M. G., Adams, P. D., & Marmorstein, R. (2015) · Nature Communications · doi:10.1038/ncomms8711 · Cited by 130 · see citing works

Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans

Chen, D., Li, P. W.-L., Goldstein, B. A., Cai, W., Thomas, E. L., Chen, F., Hubbard, A., Melov, S., & Kapahi, P. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.018 · Cited by 128 · see citing works

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

Longo, V. D. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00089-5 · Cited by 127 · see citing works

Single-tube linear DNA amplification (LinDA) for robust ChIP-seq

Shankaranarayanan, P., Mendoza-Parra, M. A., Walia, M., Wang, L., Li, N., Trindade, L. M., & Gronemeyer, H. (2011) · Nature Methods · doi:10.1038/nmeth.1626 · Cited by 125 · see citing works

Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life spanPreprint

Pu, M., Ni, Z., Wang, M., Wang, X., Wood, J. G., Helfand, S. L., Yu, H., & Lee, S. S. (2015) · Genes & Development · doi:10.1101/gad.254144.114 · Cited by 123 · see citing works

Genetics, Life Span, Health Span, and the Aging Process in Caenorhabditis elegans

Tissenbaum, H. A. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls088 · Cited by 118 · see citing works

Nucleus-Vacuole Junctions and Piecemeal Microautophagy of the Nucleus inS. cerevisiae

Kvam, E., & Goldfarb, D. S. (2007) · Autophagy · doi:10.4161/auto.3586 · Cited by 116 · see citing works

Delayed Aging in Ames Dwarf Mice. Relationships to Endocrine Function and Body Size

Bartke, A. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-48003-7_10 · Cited by 107 · see citing works

Hutchinson–Gilford progeria syndrome through the lens of transcription

Prokocimer, M., Barkan, R., & Gruenbaum, Y. (2013) · Aging Cell · doi:10.1111/acel.12070 · Cited by 97 · see citing works

TOR and ageing: a complex pathway for a complex process

McCormick, M. A., Tsai, S., & Kennedy, B. K. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0198 · Cited by 95 · see citing works

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

Norton, L., Fourcaudot, M. J., Abdul-Ghani, M. A., Winnier, D. A., Mehta, F. F., Jenkinson, C. P., & DeFronzo, R. A. (2011) · Diabetologia · doi:10.1007/s00125-011-2289-z · Cited by 92 · see citing works

The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis

Chen, H., Fan, M., Pfeffer, L. M., & Laribee, R. N. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks345 · Cited by 89 · see citing works

Metabolic and Neuropsychiatric Effects of Calorie Restriction and Sirtuins

Libert, S., & Guarente, L. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183800 · Cited by 89 · see citing works

Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescencePreprint

Platt, J. M., Ryvkin, P., Wanat, J. J., Donahue, G., Ricketts, M. D., Barrett, S. P., Waters, H. J., Song, S., Chavez, A., Abdallah, K. O., et al. (2013) · Genes & Development · doi:10.1101/gad.218776.113 · Cited by 89 · see citing works

Regulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk

Slack, C., Werz, C., Wieser, D., Alic, N., Foley, A., Stocker, H., Withers, D. J., Thornton, J. M., Hafen, E., & Partridge, L. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000881 · Cited by 86 · see citing works

Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response

Dang, W., Sutphin, G. L., Dorsey, J. A., Otte, G. L., Cao, K., Perry, R. M., Wanat, J. J., Saviolaki, D., Murakami, C. J., Tsuchiyama, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.004 · Cited by 83 · see citing works

Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1

Matsumoto, T., Baker, D. J., d’Uscio, L. V., Mozammel, G., Katusic, Z. S., & van Deursen, J. M. (2007) · Stroke · doi:10.1161/01.str.0000257967.86132.01 · Cited by 77 · see citing works

Caenorhabditis elegans integrates food and reproductive signals in lifespan determination

Crawford, D. K., Libina, N., & Kenyon, C. J. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00327.x · Cited by 72 · see citing works

Nuclear envelope alterations generate an aging‐like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Osorio, F. G., Varela, I., Lara, E., Puente, X. S., Espada, J., Santoro, R., Freije, J. M. P., Fraga, M. F., & López-Otı́n, C. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00621.x · Cited by 69 · see citing works

The SAGA Histone Deubiquitinase Module Controls Yeast Replicative Lifespan via Sir2 Interaction

McCormick, M. A., Mason, A. G., Guyenet, S. J., Dang, W., Garza, R. M., Ting, M. K., Moller, R. M., Berger, S. L., Kaeberlein, M. R., Pillus, L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.037 · Cited by 69 · see citing works

Transcriptional instability is not a universal attribute of aging

Warren, L. A., Rossi, D. J., Schiebinger, G. R., Weissman, I. L., Kim, S. K., & Quake, S. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00337.x · Cited by 56 · see citing works

Mutant mice with small amounts of BubR1 display accelerated age-related gliosis

Hartman, T. K., Wengenack, T. M., Poduslo, J. F., & van Deursen, J. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.012 · Cited by 54 · see citing works

Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction

Kozak, M., Chavez, A., Dang, W., Berger, S. L., Ashok, A., Guo, X., & Johnson, F. B. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.314 · Cited by 52 · see citing works

Murine Models of Life Span Extension

Quarrie, J. K., & Riabowol, K. T. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.31.re5 · Cited by 51 · see citing works

Gis1 and Rph1 Regulate Glycerol and Acetate Metabolism in Glucose Depleted Yeast Cells

Westholm, J. O., Tronnersjö, S., Nordberg, N., Olsson, I., Komorowski, J., & Ronne, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031577 · Cited by 47 · see citing works

PML, SUMOylation, and Senescence

Ivanschitz, L., de Thé, H., & Bras, M. L. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00171 · Cited by 45 · see citing works

Expression of DNA methyltransferases is influenced by growth hormone in the long-living Ames dwarf mouse in vivo and in vitro.

Armstrong, V. L., Rakoczy, S. G., Rojanathammanee, L., & Brown-Borg, H. (2014) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/glt133 · Cited by 42 · see citing works

Chemical regulation of mid- and late-life longevities in Drosophila

McDonald, P. J., Maizi, B. M., & Arking, R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.09.006 · Cited by 35 · see citing works

Post-Translational Modification of Cellular Proteins by Ubiquitin and Ubiquitin-Like Molecules: Role in Cellular Senescence and Aging

Grillari, J., Grillari‐Voglauer, R., & Jansen‐Dürr, P. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7002-2_13 · Cited by 34 · see citing works

The Fruit Fly Drosophila melanogaster as a Model for Aging Research

Brandt, A., & Vilcinskas, A. (2013) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2013_193 · Cited by 32 · see citing works

Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans

Rytinki, M. M., Lakso, M., Pehkonen, P., Aarnio, V., Reisner, K., Peräkylä, M., Wong, G., & Palvimo, J. J. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0627-4 · Cited by 18 · see citing works

Drosophila longevity is not affected by heterochromatin‐mediated gene silencing

Frankel, S. A., & Rogina, B. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00143.x · Cited by 17 · see citing works

Rate of Growth and Length of Life

SHERMAN, H. C., & Campbell, H. (1935) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.21.5.235 · Cited by 12 · see citing works

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., & Li, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01251-0 · Cited by 1,834 · see citing works

Epigenetic plasticity and the hallmarks of cancer

Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340 · see citing works

Idiopathic pulmonary fibrosis

Martinez, F. J., Collard, H. R., Pardo, A., Raghu, G., Richeldi, L., Selman, M., Swigris, J. J., Taniguchi, H., & Wells, A. U. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.74 · Cited by 1,388 · see citing works

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Dou, Z., Ghosh, K., Vizioli, M. G., Zhu, J., Sen, P., Wangensteen, K. J., Simithy, J., Lan, Y., Lin, Y., Zhou, Z., et al. (2017) · Nature · doi:10.1038/nature24050 · Cited by 1,335 · see citing works

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

Alberti, S., & Hyman, A. A. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00326-6 · Cited by 1,135 · see citing works

Mitochondrial dysfunction in cell senescence and aging

Miwa, S., Kashyap, S., Chini, E., & von Zglinicki, T. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158447 · Cited by 1,061 · see citing works

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.

Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.052 · Cited by 988 · see citing works

Immunosenescence: molecular mechanisms and diseases

Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 1,023 · see citing works

Unmasking senescence: context-dependent effects of SASP in cancer

Faget, D. V., Ren, Q., & Stewart, S. A. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0156-2 · Cited by 863 · see citing works

Reprogramming to recover youthful epigenetic information and restore vision

Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D. L., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2020) · Nature · doi:10.1038/s41586-020-2975-4 · Cited by 820 · see citing works

Benefits of Metformin in Attenuating the Hallmarks of Aging

Kulkarni, A. S., Gubbi, S., & Barzilai, N. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.001 · Cited by 766 · see citing works

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works

Loss of epigenetic information as a cause of mammalian aging

Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.027 · Cited by 643 · see citing works

The roles of DNA, RNA and histone methylation in ageing and cancer

Michalak, E. M., Burr, M. L., Bannister, A. J., & Dawson, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0143-1 · Cited by 549 · see citing works

Molecular and physiological manifestations and measurement of aging in humans

Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530 · see citing works

The ageing epigenome and its rejuvenation

Zhang, W., Qu, J. T., Liu, G., & Belmonte, J. C. I. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0204-5 · Cited by 472 · see citing works

The role of retrotransposable elements in ageing and age-associated diseases

Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J. D., Linker, S. B., Gage, F. H., Kreiling, J. A., Petrashen, A. P., et al. (2021) · Nature · doi:10.1038/s41586-021-03542-y · Cited by 457 · see citing works

Evaluating intrinsic and non-intrinsic cancer risk factors

Wu, S., Zhu, W., Thompson, P. A., & Hannun, Y. A. (2018) · Nature Communications · doi:10.1038/s41467-018-05467-z · Cited by 439 · see citing works

Aging Hallmarks and the Role of Oxidative Stress

Maldonado, E., Morales, S., Urbina, F., & Solari, A. (2023) · Antioxidants · doi:10.3390/antiox12030651 · Cited by 454 · see citing works

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 410 · see citing works

Universal DNA methylation age across mammalian tissues

Lu, A. T.-H., Fei, Z., Haghani, A., Robeck, T. R., Zoller, J. A., Li, C. Z., Lowe, R., Yan, Q. J., Zhang, J., Vu, H., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00462-6 · Cited by 495 · see citing works

Epigenetic Regulation in Neurodegenerative Diseases

Berson, A., Nativio, R., Berger, S. L., & Bonini, N. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.05.005 · Cited by 386 · see citing works

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

Benayoun, B. A., Pollina, E. A., Singh, P. P., Mahmoudi, S., Harel, I., Casey, K. M., Dulken, B. W., Kundaje, A., & Brunet, A. (2019) · Genome Research · doi:10.1101/gr.240093.118 · Cited by 360 · see citing works

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Nativio, R., Lan, Y., Donahue, G., Sidoli, S., Berson, A., Srinivasan, A. R., Shcherbakova, O., Amlie-Wolf, A., Nie, J., Cui, X., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0696-0 · Cited by 380 · see citing works

SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species

Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.043 · Cited by 353 · see citing works

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

Nativio, R., Donahue, G., Berson, A., Lan, Y., Amlie-Wolf, A., Tuzer, F., Toledo, J. B., Gosai, S. J., Gregory, B. D., Torres, C., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0101-9 · Cited by 363 · see citing works

Guidelines for minimal information on cellular senescence experimentation in vivo

Ogrodnik, M., Carlos Acosta, J., Adams, P. D., d’Adda di Fagagna, F., Baker, D. J., Bishop, C. L., Chandra, T., Collado, M., Gil, J., Gorgoulis, V., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.059 · Cited by 376 · see citing works

Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Fitzgerald, K. N., Hodges, R., Hanes, D., Stack, E., Cheishvili, D., Szyf, M., Henkel, J., Twedt, M. W., Giannopoulou, D., Herdell, J., et al. (2021) · Aging · doi:10.18632/aging.202913 · Cited by 361 · see citing works

Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic

Liu, P., Zhao, H., & Luo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2017.0816 · Cited by 348 · see citing works

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

Han, S., Schroeder, E. A., Silva-García, C. G., Hebestreit, K., Mair, W. B., & Brunet, A. (2017) · Nature · doi:10.1038/nature21686 · Cited by 314 · see citing works

The role of histone modifications: from neurodevelopment to neurodiseases

Park, J., Lee, K., Kim, K., & Yi, S.-J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01078-9 · Cited by 321 · see citing works

Aging and Alzheimer's disease: comparison and associations from molecular to system level

Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018) · Aging Cell · doi:10.1111/acel.12802 · Cited by 301 · see citing works

Epigenetic changes during aging and their reprogramming potential

Kane, A. E., & Sinclair, D. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1570075 · Cited by 283 · see citing works

Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging

Fournet, M., Bonté, F., & Desmoulière, A. (2018) · Aging and Disease · doi:10.14336/ad.2017.1121 · Cited by 300 · see citing works

Epigenetic Modifications in Cardiovascular Aging and Diseases

Zhang, W., Song, M., Qu, J. T., & Liu, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312497 · Cited by 291 · see citing works

Molecular mechanisms of environmental exposures and human disease

Wu, H., Eckhardt, C. M., & Baccarelli, A. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-022-00569-3 · Cited by 279 · see citing works

Regulation of Stem Cell Aging by Metabolism and Epigenetics

Ren, R., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.019 · Cited by 269 · see citing works

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276 · see citing works

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

Chen, M. B., Yang, A. C., Yousef, H., Lee, D., Chen, W., Schaum, N., Lehallier, B., Quake, S. R., & Wyss-Coray, T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.012 · Cited by 233 · see citing works

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

Gasparoni, G., Bultmann, S., Lutsik, P., Kraus, T. F. J., Sordon, S., Vlcek, J., Dietinger, V., Steinmaurer, M., Haider, M., Mulholland, C. B., et al. (2018) · Epigenetics &amp; Chromatin · doi:10.1186/s13072-018-0211-3 · Cited by 229 · see citing works

Sirtuins, epigenetics and longevity

Wątroba, M., Dudek, I., Skoda, M., Stangret, A., Rzodkiewicz, P., & Szukiewicz, D. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.08.001 · Cited by 221 · see citing works

Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease

Qian, X., Xie, R.-Y., Liu, X., Chen, S., & Tang, H. (2022) · Aging and Disease · doi:10.14336/ad.2021.1215 · Cited by 219 · see citing works

The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy

Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works

Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development

Tan, L., Ma, W., Wu, H., Zheng, Y., Xing, D., Chen, R., Li, X., Daley, N., Deisseroth, K. A., & Xie, X. S. (2021) · Cell · doi:10.1016/j.cell.2020.12.032 · Cited by 190 · see citing works

Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging

Wu, N. N., Zhang, Y., & Ren, J. T. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9825061 · Cited by 196 · see citing works

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA

Wu, Z., Shi, Y. X., Lu, M., Song, M., Yu, Z., Wang, J., Wang, S., Ren, J., Yang, Y., Liu, G., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa816 · Cited by 190 · see citing works

Molecular and phenotypic biomarkers of aging

Xia, X., Chen, W., McDermott, J., & Han, J.-D. J. (2017) · F1000Research · doi:10.12688/f1000research.10692.1 · Cited by 187 · see citing works

Advances in Understanding of the Role of Lipid Metabolism in Aging

Chung, K. W. (2021) · Cells · doi:10.3390/cells10040880 · Cited by 185 · see citing works

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

Bradshaw, P. C. (2021) · Antioxidants · doi:10.3390/antiox10040572 · Cited by 185 · see citing works

Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives

Zhang, M., Salas, S. S., Damba, T., Borghesan, M., Demaria, M., & Moshage, H. J. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111572 · Cited by 180 · see citing works

Hallmarks of the aging T‐cell system

Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021) · FEBS Journal · doi:10.1111/febs.15770 · Cited by 177 · see citing works

Antioxidative nanomaterials and biomedical applications

Liu, Y., & Shi, J. (2019) · Nano Today · doi:10.1016/j.nantod.2019.05.008 · Cited by 173 · see citing works

Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence

Gude, N. A., Broughton, K. M., Firouzi, F., & Sussman, M. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0061-5 · Cited by 166 · see citing works

DNA methylation predicts age and provides insight into exceptional longevity of bats

Wilkinson, G. S., Adams, D. M., Haghani, A., Lu, A. T.-H., Zoller, J. A., Breeze, C. E., Arnold, B. D., Ball, H. C., Carter, G. G., Cooper, L. N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21900-2 · Cited by 175 · see citing works

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

Al‐Azab, M., Safi, M., Idiiatullina, E., Al‐Shaebi, F., & Zaky, M. Y. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00366-0 · Cited by 172 · see citing works

BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy

Meyer, D. H., & Schumacher, B. (2021) · Aging Cell · doi:10.1111/acel.13320 · Cited by 165 · see citing works

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence

Sen, P., Lan, Y., Li, C. Y., Sidoli, S., Donahue, G., Dou, Z., Frederick, B., Chen, Q., Luense, L. J., Garcia, B. A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.021 · Cited by 164 · see citing works

Loss of KDM4B Exacerbates Bone-Fat Imbalance and Mesenchymal Stromal Cell Exhaustion in Skeletal Aging

Deng, P., Yuan, Q., Cheng, Y., Li, J., Liu, Z.-Q., Liu, Y., Li, Y., Su, T., Wang, J., Salvo, M. E., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.01.010 · Cited by 155 · see citing works

Epigenetics, DNA damage, and aging

Soto-Palma, C., Niedernhofer, L. J., Faulk, C. D., & Dong, X. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158446 · Cited by 153 · see citing works

WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration

Li, G., Ma, L., He, S., Luo, R., Wang, B., Zhang, W., Song, Y., Liao, Z., Ke, W., Xiang, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28990-6 · Cited by 155 · see citing works

Metabolic programs tailor T cell immunity in viral infection, cancer, and aging

Møller, S. H., Hsueh, P., Yu, Y.-R., Zhang, L., & Ho, P. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.02.003 · Cited by 148 · see citing works

Heterochromatin: an epigenetic point of view in aging

Lee, J., Kim, E. W., Croteau, D. L., & Bohr, V. A. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00497-4 · Cited by 154 · see citing works

Fruit development and epigenetic modifications

Tang, D., Gallusci, P., & Lang, Z. (2020) · New Phytologist · doi:10.1111/nph.16724 · Cited by 148 · see citing works

Linking Lipid Metabolism to Chromatin Regulation in Aging

Papsdorf, K., & Brunet, A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.09.004 · Cited by 150 · see citing works

Cellular proteostasis decline in human senescence

Sabath, N., Levy‐Adam, F., Younis, A., Rozales, K., Meller, A., Hadar, S., Soueid‐Baumgarten, S., & Shalgi, R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018138117 · Cited by 148 · see citing works

Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

Delgado‐Morales, R., Agís‐Balboa, R. C., Esteller, M., & Berdasco, M. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0365-z · Cited by 143 · see citing works

Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases

Orioli, D., & Dellambra, E. (2018) · Cells · doi:10.3390/cells7120268 · Cited by 144 · see citing works

Dynamic DNA methylation during aging: A "prophet" of age-related outcomes

Xiao, F.-H., Wang, H.-T., & Kong, Q.-P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00107 · Cited by 140 · see citing works

Vitamin D deficiency accelerates ageing and age‐related diseases: a novel hypothesis

Berridge, M. J. (2017) · The Journal of Physiology · doi:10.1113/jp274887 · Cited by 142 · see citing works

Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development

Ashapkin, V. V., Suvorov, A., Pilsner, J. R., Krawetz, S. A., & Sergeyev, O. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmac033 · Cited by 143 · see citing works

Genome-wide RNA polymerase stalling shapes the transcriptome during aging

Gyenis, Á., Chang, J., Demmers, J. J. P. G., Bruens, S. T., Barnhoorn, S., Brandt, R. M. C., Baar, M. P., Rašeta, M., Derks, K., Hoeijmakers, J. H. J., et al. (2023) · Nature Genetics · doi:10.1038/s41588-022-01279-6 · Cited by 136 · see citing works

The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing

Liu, Y., Tan, Y., Zhang, Z., Yi, M., Zhu, L., & Peng, W. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00397-x · Cited by 144 · see citing works

Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

Ma, Z., Wang, H., Cai, Y. A., Wang, H., Niu, K., Wu, X., Ma, H., Yang, Y., Tong, W., Liu, F., et al. (2018) · eLife · doi:10.7554/elife.35368 · Cited by 132 · see citing works

Universal DNA methylation age across mammalian tissuesPreprint

Lu, A. T., Fei, Z., Haghani, A., Robeck, T. R., Zoller, J. A., Li, C., Lowe, R., Yan, Q. J., Zhang, J., Vu, H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.18.426733 · Cited by 139 · see citing works

Putting the brakes on the cell cycle: mechanisms of cellular growth arrest

Pack, L. R., Daigh, L. H., & Meyer, T. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.05.005 · Cited by 130 · see citing works

New Insights into the Role of Histone Changes in Aging

Yi, S.-J., & Kim, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218241 · Cited by 132 · see citing works

Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer

Xue, C., Zhao, Y., & Li, L. (2020) · Biomarker Research · doi:10.1186/s40364-020-00225-0 · Cited by 130 · see citing works

Self-defense of macrophages against oxidative injury: Fighting for their own survival

Virág, L., Jaén, R. I., Regdon, Z., Boscá, L., & Prieto, P. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101261 · Cited by 121 · see citing works

A homeostatic Arid1a-dependent permissive chromatin state licenses hepatocyte responsiveness to liver-injury-associated YAP signaling

Li, W., Yang, L., He, Q., Hu, C., Zhu, L., Ma, X., Ma, X., Bao, S., Li, L., Chen, Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.06.008 · Cited by 124 · see citing works

The Mediterranean Diet Slows Down the Progression of Aging and Helps to Prevent the Onset of Frailty: A Narrative Review

Capurso, C. A., Bellanti, F., Buglio, A. L., & Vendemiale, G. (2019) · Nutrients · doi:10.3390/nu12010035 · Cited by 120 · see citing works

In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.

Rodríguez-Matellán, A., Alcazar, N., Hernández, F., Serrano, M., & Ávila, J. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.09.010 · Cited by 116 · see citing works

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence

Wu, Y., Tang, L., Huang, H., Yu, Q., Hu, B., Wang, G., Ge, F., Yin, T., Li, S., & Yu, X. (2023) · Nature Communications · doi:10.1038/s41467-023-37094-8 · Cited by 119 · see citing works

Epigenetic Mechanisms of Aging and Aging-Associated Diseases

la Torre, A., Vecchio, F. L., & Greco, A. (2023) · Cells · doi:10.3390/cells12081163 · Cited by 120 · see citing works

Consensus Paper: Cerebellum and Ageing

Arleo, A., Bareš, M., Bernard, J. A., Bogoian, H. R., Bruchhage, M. M. K., Bryant, P., Carlson, E. S., Chan, C. C. H., Chen, L., Chung, C., et al. (2023) · The Cerebellum · doi:10.1007/s12311-023-01577-7 · Cited by 125 · see citing works

The role of epigenetics in renal ageing

Shiels, P. G., McGuinness, D., Eriksson, M., Kooman, J. P., & Stenvinkel, P. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.78 · Cited by 114 · see citing works

Two conserved epigenetic regulators prevent healthy ageing

Yuan, J., Chang, S., Yin, S., Liu, Z.-Y., Cheng, X., Liu, X., Jiang, Q., Gao, G., Lin, D.-Y., Kang, X.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2037-y · Cited by 111 · see citing works

Sample multiplexing for targeted pathway proteomics in aging mice

Yu, Q., Xiao, H., Jedrychowski, M. P., Schweppe, D. K., Navarrete-Perea, J., Knott, J., Rogers, J. C., Chouchani, E. T., & Gygi, S. P. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919410117 · Cited by 112 · see citing works

Current Perspective in the Discovery of Anti-aging Agents from Natural Products

Ding, A., Zheng, S., Huang, X., Xing, T.-K., Wu, G.-S., Sun, H., Qi, S., & Luo, H. (2017) · Natural Products and Bioprospecting · doi:10.1007/s13659-017-0135-9 · Cited by 114 · see citing works

Basic science and pathogenesis of ageing with HIV

Lagathu, C., Cossarizza, A., Béréziat, V., Nasi, M., Capeau, J., & Pinti, M. (2017) · AIDS · doi:10.1097/qad.0000000000001441 · Cited by 108 · see citing works

Epigenetic Priming in Cancer Initiation

Vicente‐Dueñas, C., Hauer, J., Cobaleda, C., Borkhardt, A., & Sánchez-Garcı́a, I. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.04.007 · Cited by 107 · see citing works

Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

Liu, Z., Ji, Q., Ren, J., Yan, P., Wu, Z., Wang, S., Sun, L., Wang, Z., Li, J., Sun, G., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.05.004 · Cited by 109 · see citing works

Sirtuin 6: linking longevity with genome and epigenome stability

Korotkov, A., Seluanov, A., & Gorbunova, V. A. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.06.009 · Cited by 114 · see citing works

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

Cassidy, L. D., Young, A. R. J., Young, C. N. J., Soilleux, E. J., Fielder, E., Weigand, B. M., Lagnado, A., Brais, R., Ktistakis, N. T., Wiggins, K. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14187-x · Cited by 108 · see citing works

The Role of microRNAs in Organismal and Skin Aging

Gerasymchuk, M., Cherkasova, V., Kovalchuk, O., & Kovalchuk, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155281 · Cited by 111 · see citing works

Histone Modifications in Alzheimer’s Disease

Santana, D. A., Smith, M. D. A. C., & Chen, E. (2023) · Genes · doi:10.3390/genes14020347 · Cited by 109 · see citing works

Genomic Instability and Epigenetic Changes during Aging

López-Gil, L., Pascual‐Ahuir, A., & Proft, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814279 · Cited by 120 · see citing works

Effects of exercise on cellular and tissue aging

Carapeto, P. V., & Aguayo-Mazzucato, C. (2021) · Aging · doi:10.18632/aging.203051 · Cited by 107 · see citing works

Inflammation and its resolution and the musculoskeletal system

Gallo, J., Raška, M., Kriegová, E., & Goodman, S. B. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.05.007 · Cited by 107 · see citing works

Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1

Martin-Herranz, D. E., Aref‐Eshghi, E., Bonder, M. J., Stubbs, T. M., Choufani, S., Weksberg, R., Stegle, O., Sadiković, B., Reik, W., & Thornton, J. M. (2019) · Genome biology · doi:10.1186/s13059-019-1753-9 · Cited by 100 · see citing works

The Impact of Caloric Restriction on the Epigenetic Signatures of Aging

Gensous, N., Franceschi, C., Santoro, A., Milazzo, M., Garagnani, P., & Bacalini, M. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20082022 · Cited by 103 · see citing works

Epigenetic Mechanisms of Aging and Aging-Associated Diseases

la Torre, A., Vecchio, F. L., & Greco, A. (2023) · Cells · doi:10.3390/cells12081163 · Cited by 120 · see citing works

Mechanisms and interventions of epigenetic aging

Chu, Q., Li, Y., Wu, Z., Qu, J. T., & Liu, G. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2026.05.007 · Cited by 4 · see citing works

The Epigenetics of Aging in Invertebrates

Yu, G., Wu, Q., Gao, Y., Chen, M., & Yang, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184535 · Cited by 29 · see citing works

Epigenetic Control of Aging

Muñoz-Nájar, U., & Sedivy, J. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3250 · Cited by 113 · see citing works

Epigenetic regulation of aging: implications for interventions of aging and diseases

Kang, W., Liu, H., Hu, Q., Wang, L., Liu, J., Zheng, Z., Zhang, W., Ren, J., Zhu, F., & Liu, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01211-8 · Cited by 694 · see citing works