The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Reconstruction of functionally normal and malignant human breast tissues in mice
Open accessAbstract
The study of normal breast epithelial morphogenesis and carcinogenesis in vivo has largely used rodent models. Efforts at studying mammary morphogenesis and cancer with xenotransplanted human epithelial cells have failed to recapitulate the full extent of development seen in the human breast. We have developed an orthotopic xenograft model in which both the stromal and epithelial components of the reconstructed mammary gland are of human origin. Genetic modification of human stromal cells before the implantation of ostensibly normal human mammary epithelial cells resulted in the outgrowth of benign and malignant lesions. This experimental model allows for studies of human epithelial morphogenesis and differentiation in vivo and underscores the critical role of heterotypic interactions in human breast development and carcinogenesis.
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Cites
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Cited by
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538
The biology and function of fibroblasts in cancer
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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
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Metadata
- Authors
- Kuperwasser, C., Chavarria, T., Wu, M., Magrane, G., Gray, J. W., Carey, L., Richardson, A., & Weinberg, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-03-29
- Volume
- 101
- Issue
- 14
- Pages
- 4966-4971
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2162647235
- Cited by
- 804
- References
- 20
- FWCI
- 20.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Kuperwasser, C., Chavarria, T., Wu, M., Magrane, G., Gray, J. W., Carey, L., Richardson, A., & Weinberg, R. A. (2004). Reconstruction of functionally normal and malignant human breast tissues in mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0401064101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
