Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Open accessAbstract
Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found that breast tumorigenesis is accompanied by collagen crosslinking, ECM stiffening, and increased focal adhesions. Induction of collagen crosslinking stiffened the ECM, promoted focal adhesions, enhanced PI3 kinase (PI3K) activity, and induced the invasion of an oncogene-initiated epithelium. Inhibition of integrin signaling repressed the invasion of a premalignant epithelium into a stiffened, crosslinked ECM and forced integrin clustering promoted focal adhesions, enhanced PI3K signaling, and induced the invasion of a premalignant epithelium. Consistently, reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence. These data show how collagen crosslinking can modulate tissue fibrosis and stiffness to force focal adhesions, growth factor signaling and breast malignancy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ECM anisotropy, crosslinking, and stiffening are interlinked, with each promoting local carcinoma invasion by enhancing integrin signaling.
“ECM anisotropy, crosslinking, and stiffening are interlinked, with each of them promoting local carcinoma invasion by enhancing integrin signaling”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [20]
As a result of collagen remodeling, connective tissues surrounding tumor-loaded mammary glands stiffen up to eight-fold (from 0.2 to 1.5 kPa), densify, and straighten with tumor formation, as detected in murine cancer models and clinical biopsies.
“As a result of collagen remodeling, connective tissues surrounding tumor-loaded mammary glands stiffen up to eight-fold (i.e., from 0.2 to 1.5 kPa), densify, and straighten with tumor formation, as detected in murine cancer models and clinical biopsies [20,21].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [20]
Oriented fiber tracks mediate focal contact orientation and contact guidance along 'highways', ultimately leading to higher tumor incidence.
“oriented fiber tracks mediating focal contact orientation and contact guidance along 'highways', ultimately leading to higher tumor incidence [20,22,23].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [20]
ECM anisotropy is a hallmark in many cancers.
“Because ECM anisotropy is a hallmark in many cancers”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309 · see citing works
Self-citationRetractedCoussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915 · see citing works
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606 · see citing works
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382 · see citing works
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108 · see citing works
Self-citationHow Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959 · see citing works
Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941 · see citing works
Self-citationCell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289 · see citing works
Cell locomotion and focal adhesions are regulated by substrate flexibility.
Pelham, R., & Wang, Y.-L. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.25.13661 · Cited by 3,156 · see citing works
Matrix metalloproteinases and the regulation of tissue remodelling
Page, A. W., Ewald, A. J., & Werb, Z. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2125 · Cited by 3,011 · see citing works
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
Coussens, L. M., Fingleton, B., & Matrisian, L. M. (2002) · Science · doi:10.1126/science.1067100 · Cited by 2,761 · see citing works
Mammographic Density and the Risk and Detection of Breast Cancer
Boyd, N. F., Guo, H., Martin, L. J., Sun, L., Stone, J., Fishell, E., Jong, R. A., Hislop, G., Chiarelli, A. M., Minkin, S., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa062790 · Cited by 2,482 · see citing works
A molecular signature of metastasis in primary solid tumors
Ramaswamy, S., Ross, K. N., Lander, E. S., & Golub, T. R. (2002) · Nature Genetics · doi:10.1038/ng1060 · Cited by 2,448 · see citing works
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325 · see citing works
Self-citationHypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300 · see citing works
Self-citationBissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180 · see citing works
A tense situation: forcing tumour progression
Butcher, D. T., Alliston, T. N., & Weaver, V. M. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2544 · Cited by 1,922 · see citing works
Self-citationCollagen reorganization at the tumor-stromal interface facilitates local invasion
Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G., & Keely, P. J. (2006) · BMC Medicine · doi:10.1186/1741-7015-4-38 · Cited by 1,804 · see citing works
Elastic Moduli of Breast and Prostate Tissues under Compression
Krouskop, T. A., Wheeler, T. M., Kallel, F., et al. (1998) · Ultrasonic Imaging · doi:10.1177/016173469802000403 · Cited by 1,711 · see citing works
COLLAGENS: Molecular Biology, Diseases, and Potentials for Therapy
Prockop, D. J., & Kivirikko, K. I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.002155 · Cited by 1,625 · see citing works
Integrin-regulated FAK–Src signaling in normal and cancer cells
Mitra, S. K., & Schlaepfer, D. D. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.08.011 · Cited by 1,591 · see citing works
Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483 · see citing works
Self-citationIntegrin signalling during tumour progression
Guo, W., & Giancotti, F. G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1490 · Cited by 1,473 · see citing works
Kadler, K. E., Holmes, D. F., Trotter, J. A., & Chapman, J. A. (1996) · Biochemical Journal · doi:10.1042/bj3160001 · Cited by 1,452 · see citing works
Collagen density promotes mammary tumor initiation and progression
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C., White, J. G., & Keely, P. J. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-11 · Cited by 1,364 · see citing works
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346 · see citing works
Matrix Metalloproteinases: Role In Arthritis
Peter, S. B. (2006) · Frontiers in bioscience · doi:10.2741/1817 · Cited by 1,294 · see citing works
TGFβ: the molecular Jekyll and Hyde of cancer
Bierie, B., & Moses, H. L. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1926 · Cited by 1,262 · see citing works
Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.11.012 · Cited by 1,231 · see citing works
Self-citationRole of extracellular matrix assembly in interstitial transport in solid tumors.
Netti, P. A., Berk, D. A., Swartz, M. A., Grodzinsky, A. J., & Jain, R. K. (2000) · PubMed · Cited by 1,165 · see citing works
Zaman, M. H., Trapani, L. M., Sieminski, A. L., MacKellar, D. C., Gong, H., Kamm, R. D., Wells, A. H., Lauffenburger, D. A., & Matsudaira, P. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604460103 · Cited by 1,159 · see citing works
Delcommenne, M., Tan, C., Gray, V., Rue, L., Woodgett, J., & Dedhar, S. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.19.11211 · Cited by 1,149 · see citing works
Cross-linking in collagen and elastin.
Eyre, D. R., Paz, M. A., & Gallop, P. (1984) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.53.070184.003441 · Cited by 1,133 · see citing works
Synthetic nano-scale fibrous extracellular matrix
Ma, P. X., & Zhang, R. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199907)46:1 · Cited by 1,055 · see citing works
Wolf, K., Wu, Y., Liu, Y., Geiger, J., Tam, E. M., Overall, C. M., Stack, M. S., & Friedl, P. (2007) · Nature Cell Biology · doi:10.1038/ncb1616 · Cited by 1,009 · see citing works
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
Kagan, H. M., & Li, W. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10413 · Cited by 954 · see citing works
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
Coussens, L. M., Raymond, W. W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G. H., & Hanahan, D. (1999) · Genes & Development · doi:10.1101/gad.13.11.1382 · Cited by 946 · cited 1× · see citing works
“Tissue fibrosis influences tumor progression by regulating soluble factors that induce inflammation and angiogenesis and stimulate cell growth and invasion (Bierie et al., 2009; Coussens et al., 1999).”
BackgroundForce Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas
Sawada, Y., Tamada, M., Dubin‐Thaler, B. J., Cherniavskaya, O., Sakai, R., Tanaka, S., & Sheetz, M. P. (2006) · Cell · doi:10.1016/j.cell.2006.09.044 · Cited by 945 · see citing works
The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis
Sternlicht, M. D., Lochter, A., Sympson, C. J., Huey, B., Rougier, J., Gray, J. W., Pinkel, D., Bissell, M. J., & Werb, Z. (1999) · Cell · doi:10.1016/s0092-8674(00)81009-0 · Cited by 924 · see citing works
Mechanisms of Disease: understanding resistance to HER2-targeted therapy in human breast cancer
Nahta, R., Yu, D., Hung, M., Hortobágyi, G. N., & Esteva, F. J. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0509 · Cited by 916 · see citing works
Sensing the environment: a historical perspective on integrin signal transduction
Miranti, C. K., & Brugge, J. S. (2002) · Nature Cell Biology · doi:10.1038/ncb0402-e83 · Cited by 851 · see citing works
Reconstruction of functionally normal and malignant human breast tissues in mice
Kuperwasser, C., Chavarria, T. E., Wu, M., Magrane, G., Gray, J. W., Carey, L., Richardson, A. L., & Weinberg, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401064101 · Cited by 807 · see citing works
Rønnov‐Jessen, L., PETERSEN, O. W., & Bissell, M. J. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.1.69 · Cited by 797 · see citing works
Weaver, V. M., Lelièvre, S. A., Lakins, J. N., Chrenek, M. A., Jones, J., Giancotti, F. G., Werb, Z., & Bissell, M. J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00125-3 · Cited by 794 · see citing works
Self-citationMechanical properties and Young's modulus of human skin in vivo
Agache, P. G., Monneur, C., Lévêque, J., & de Rigal, J. (1980) · Archives of Dermatological Research · doi:10.1007/bf00406415 · Cited by 742 · see citing works
Substrate flexibility regulates growth and apoptosis of normal but not transformed cells
Wang, H.-B., Dembo, M., & Wang, Y. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.5.c1345 · Cited by 655 · see citing works
Metalloproteinases: role in breast carcinogenesis, invasion and metastasis
Duffy, M. J., Maguire, T. M., Hill, A. D. K., McDermott, E. W. M., & O’Higgins, N. J. (2000) · Breast Cancer Research · doi:10.1186/bcr65 · Cited by 628 · see citing works
Heritability of Mammographic Density, a Risk Factor for Breast Cancer
Boyd, N. F., Dite, G. S., Stone, J., Gunasekara, A., English, D. R., McCredie, M. R. E., Giles, G. G., Tritchler, D., Chiarelli, A. M., Yaffe, M. J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013390 · Cited by 612 · see citing works
Lysyl oxidase: an oxidative enzyme and effector of cell function
Lucero, H. A., & Kagan, H. M. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6149-9 · Cited by 608 · see citing works
Whitelock, J. M., Murdoch, A. D., Iozzo, R. V., & Underwood, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.10079 · Cited by 597 · see citing works
Sabeh, F., Ota, I., Holmbeck, K., Birkedal‐Hansen, H., Soloway, P. D., Balbı́n, M., López-Otı́n, C., Shapiro, S. D., Inada, M., Krane, S. M., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408028 · Cited by 586 · see citing works
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577 · see citing works
Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation
Elenbaas, B., & Weinberg, R. A. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5133 · Cited by 557 · see citing works
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
Muthuswamy, S. K., Li, D., Lelièvre, S. A., Bissell, M. J., & Brugge, J. S. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-785 · Cited by 554 · see citing works
Traction Force Microscopy of Migrating Normal and H-ras Transformed 3T3 Fibroblasts
Munevar, S., Wang, Y., & Dembo, M. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76145-0 · Cited by 529 · see citing works
Wozniak, M. A., Desai, R. C., Solski, P. A., Der, C. J., & Keely, P. J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305010 · Cited by 515 · see citing works
Lysyl oxidases: A novel multifunctional amine oxidase family
Csiszar, K. (2001) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(01)70012-8 · Cited by 514 · see citing works
Self-citationFocal adhesion kinase is involved in mechanosensing during fibroblast migration
Wang, H.-B., Dembo, M., Hanks, S. K., & Wang, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201201198 · Cited by 503 · see citing works
Regulation of In Situ to Invasive Breast Carcinoma Transition
Hu, M., Yao, J., Carroll, D. K., Weremowicz, S., Chen, H., Carrasco, D. R., Richardson, A. L., Violette, S. M., Nikolskaya, T., Nikolsky, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.03.007 · Cited by 497 · see citing works
Extracellular Matrix Degradation and the Role of Hepatic Stellate Cells
Benyon, R. C., & Arthur, M. J. P. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-17552 · Cited by 489 · see citing works
High-resolution tensor MR elastography for breast tumour detection
Sinkus, R., Lorenzen, J., Schrader, D., Lorenzen, M., Dargatz, M., & Holz, D. (2000) · Physics in Medicine and Biology · doi:10.1088/0031-9155/45/6/317 · Cited by 481 · see citing works
White, D. E., Kurpios, N. A., Zuo, D., Hassell, J. A., Blaess, S., Mueller, U., & Muller, W. J. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.025 · Cited by 413 · see citing works
Malignant MCF10CA1 Cell Lines Derived from Premalignant Human Breast Epithelial MCF10AT Cells
Santner, S. J., Dawson, P. J., Tait, L. R., Soule, H. D., Eliason, J. F., Mohamed, A. N., Wolman, S. R., Heppner, G. H., & Miller, F. R. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1006461422273 · Cited by 409 · see citing works
Viral hepatitis and liver cancer: the case of hepatitis C
Levrero, M. (2006) · Oncogene · doi:10.1038/sj.onc.1209562 · Cited by 407 · see citing works
Tanzer, M. L. (1973) · Science · doi:10.1126/science.180.4086.561 · Cited by 389 · see citing works
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
Bergamaschi, A., Tagliabue, E., Sørlie, T., Naume, B., Triulzi, T., Orlandi, R., Russnes, H., Nesland, J. M., Tammi, R., Auvinen, P., et al. (2007) · The Journal of Pathology · doi:10.1002/path.2278 · Cited by 387 · see citing works
Martin, L. J., & Boyd, N. F. (2008) · Breast Cancer Research · doi:10.1186/bcr1831 · Cited by 373 · see citing works
Muthuswamy, S. K., Gilman, M. Z., & Brugge, J. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.6845 · Cited by 366 · see citing works
Mechanotransduction through growth-factor shedding into the extracellular space
Tschumperlin, D. J., Dai, G., Maly, I. V., Kikuchi, T., Laiho, L. H., McVittie, A. K., Haley, K. J., Lilly, C. M., So, P. T. C., Lauffenburger, D. A., et al. (2004) · Nature · doi:10.1038/nature02543 · Cited by 353 · see citing works
Mammographic density, breast cancer risk and risk prediction
Vachon, C. M., van Gils, C. H., Sellers, T. A., et al. (2007) · Breast Cancer Research · doi:10.1186/bcr1829 · Cited by 348 · see citing works
Integrin-linked kinase – essential roles in physiology and cancer biology
McDonald, P. C., Fielding, A. B., & Dedhar, S. (2008) · Journal of Cell Science · doi:10.1242/jcs.017996 · Cited by 344 · see citing works
Nelson, C. M., & Bissell, M. J. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.05.001 · Cited by 332 · see citing works
A molecular role for lysyl oxidase in breast cancer invasion.
Kirschmann, D. A., Seftor, E. A., Fong, S. F. T., Nieva, D. R. C., Sullivan, C. M., Edwards, E. M., Sommer, P., Csiszar, K., & Hendrix, M. J. C. (2002) · PubMed · Cited by 332 · see citing works
Self-citationThree-dimensional context regulation of metastasis
Erler, J. T., & Weaver, V. M. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9209-8 · Cited by 314 · see citing works
Self-citationLysyl Oxidase Is Required for Vascular and Diaphragmatic Development in Mice
Hornstra, I. K., Birge, S., STARCHER, B. C., Bailey, A. J., Mecham, R. P., & Shapiro, S. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210144200 · Cited by 309 · see citing works
Age-Dependent Changes in Material Properties of the Brain and Braincase of the Rat
Gefen, A., Gefen, N., Zhu, Q., Raghupathi, R., & Margulies, S. S. (2003) · Journal of Neurotrauma · doi:10.1089/089771503770802853 · Cited by 299 · see citing works
Mammographic density is related to stroma and stromal proteoglycan expression
Alowami, S. O., Troup, S., Al‐Haddad, S., Kirkpatrick, I. D., & Watson, P. H. (2003) · Breast Cancer Research · doi:10.1186/bcr622 · Cited by 266 · see citing works
CD98hc (SLC3A2) mediates integrin signaling
Feral, C. C., Nishiya, N., Fenczik, C. A., Stuhlmann, H., Slepak, M., & Ginsberg, M. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404852102 · Cited by 264 · see citing works
Pawlak, M., Schick, E., Bopp, M. A., Schneider, M. J., Oroszlan, P. L., & Ehrat, M. (2002) · PROTEOMICS · doi:10.1002/1615-9861(200204)2:4 · Cited by 258 · see citing works
The Role of Matrix Stiffness in Hepatic Stellate Cell Activation and Liver Fibrosis
Wells, R. G. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000155516.02468.0f · Cited by 232 · see citing works
Paradoxical roles for lysyl oxidases in cancer—A prospect
Raimondi, S. L., Hendrix, M. J. C., & Kirschmann, D. A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21371 · Cited by 232 · see citing works
Jodele, S., Blavier, L., Yoon, J. M., & DeClerck, Y. A. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-7887-8 · Cited by 231 · see citing works
Stromagenesis: The changing face of fibroblastic microenvironments during tumor progression
Beacham, D. A., & Cukierman, E. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.05.003 · Cited by 225 · see citing works
Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival
McDonald, P. C., Oloumi, A., Mills, J., Dobreva, I., Maidan, M. M., Gray, V., Wederell, E. D., Bally, M. B., Foster, L. J., & Dedhar, S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5869 · Cited by 224 · see citing works
β1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts
Park, C. C., Zhang, H. J., Yao, E. S., Park, C. J., & Bissell, M. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6390 · Cited by 220 · see citing works
A reciprocal tensin-3–cten switch mediates EGF-driven mammary cell migration
Katz, M., Amit, I., Citri, A., Shay, T., Carvalho, S., Lavi, S., Milanezi, F., Lyass, L., Amariglio, N., Jacob-Hirsch, J., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1622 · Cited by 219 · see citing works
Lysyl Oxidase Mediates Hypoxic Control of Metastasis
Erler, J. T., & Giaccia, A. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3197 · Cited by 214 · see citing works
Self-citationBiochemical and biophysical aspects of collagen nanostructure in the extracellular matrix
Koláčná, L., Bakešová, J., Varga, F., et al. (2007) · Physiological Research · doi:10.33549/physiolres.931302 · Cited by 208 · see citing works
Webster, M. A., Hutchinson, J. N., Rauh, M. J., Muthuswamy, S. K., Anton, M., Tortorice, C. G., Cardiff, R. D., Graham, F. L., Hassell, J. A., & Muller, W. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2344 · Cited by 200 · see citing works
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression
Lahlou, H., Sanguin‐Gendreau, V., Zuo, D., Cardiff, R. D., McLean, G. W., Frame, M. C., & Muller, W. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710091104 · Cited by 196 · see citing works
Fogelgren, B., Polgár, N., Szauter, K. M., Újfaludi, Z., Laczkó, R., Fong, K. S. K., & Csiszár, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412979200 · Cited by 191 · see citing works
The Role of the Epidermal Growth Factor Receptor Family in Mammary Tumorigenesis and Metastasis
Kim, H. L., & Muller, W. J. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4706 · Cited by 190 · see citing works
Matrix Elasticity, Cytoskeletal Tension, and TGF-β: The Insoluble and Soluble Meet
Wells, R. G., & Discher, D. E. (2008) · Science Signaling · doi:10.1126/stke.110pe13 · Cited by 183 · see citing works
Bill, H. M., Knudsen, B. S., Moores, S. L., Muthuswamy, S. K., Rao, V., Brugge, J. S., & Miranti, C. K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8586-8599.2004 · Cited by 183 · see citing works
Yang, X. H., Richardson, A. L., Torres-Arzayus, M. I., Zhou, P., Sharma, C., Kazarov, A. R., Andzelm, M. M., Strominger, J. L., Brown, M., & Hemler, M. E. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2949 · Cited by 183 · see citing works
Skin ageing: changes of physical properties of human skin in vivo
Diridollou, S., Vabre, V., Berson, M., Vaillant, L., Black, D., Lagarde, J., Grégoire, J., Gall, Y., & Patat, F. (2001) · International Journal of Cosmetic Science · doi:10.1046/j.0412-5463.2001.00105.x · Cited by 178 · see citing works
Tumors are unique organs defined by abnormal signaling and context
Radisky, D. C., Hagios, C., & Bissell, M. J. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0360 · Cited by 177 · see citing works
Beer, A. J., Niemeyer, M., Carlsen, J., et al. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.045526 · Cited by 174 · see citing works
Lysine Hydroxylation and Crosslinking of Collagen
Yamauchi, M., & Shiiba, M. (2003) · Humana Press eBooks · doi:10.1385/1-59259-181-7:277 · Cited by 170 · see citing works
Self-citationBondareva, A. A., Downey, C. M., Ayres, F. J., Liu, W., Boyd, S. K., Hallgrímsson, B., & Jirik, F. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005620 · Cited by 159 · see citing works
Changes in Extracellular Matrix and Tissue Viscoelasticity in Bleomycin–induced Lung Fibrosis
Ebihara, T., Venkatesan, N., Tanaka, R., & Ludwig, M. S. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.4.9912011 · Cited by 158 · see citing works
Zhang, B., Cao, X., Liu, Y., et al. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-83 · Cited by 155 · see citing works
A delicate balance: TGF‐β and the tumor microenvironment
Stover, D. G., Bierie, B., & Moses, H. L. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21149 · Cited by 139 · see citing works
Ha, H. Y., Moon, H. B., Nam, M. S., Lee, J., Ryoo, Z. Y., Lee, T., Lee, K. K., So, B. J., Sato, H., Seiki, M., et al. (2001) · PubMed · Cited by 137 · see citing works
The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis
Têtu, B., Brisson, J., Wang, C. S., et al. (2006) · Breast Cancer Research · doi:10.1186/bcr1503 · Cited by 137 · see citing works
Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases
Fowlkes, J. L., Thrailkill, K. M., Serra, D. M., et al. (1995) · Progress in Growth Factor Research · doi:10.1016/0955-2235(95)00017-8 · Cited by 136 · see citing works
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Beggs, H. E., & Keely, P. J. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080308 · Cited by 134 · see citing works
Bierie, B., Chung, C. H., Parker, J. S., Stover, D. G., Cheng, N., Chytil, A. M., Aakre, M. E., Shyr, Y., & Moses, H. L. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37480 · Cited by 134 · see citing works
Cabodi, S., Tinnirello, A. A., Stefano, P. D., Bisarò, B., Ambrosino, E., Castellano, I., Sapino, A., Arisio, R., Cavallo, F., Forni, G., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2909 · Cited by 134 · see citing works
Colpaert, C., Vermeulen, P., Fox, S. B., Harris, A. L., Dirix, L. Y., & Marck, E. A. V. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1025702330207 · Cited by 132 · see citing works
Martin, M. D., Carter, K. J., Jean-Philippe, S. R., Chang, M., Mobashery, S., Thiolloy, S., Lynch, C. C., Matrisian, L. M., & Fingleton, B. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0537 · Cited by 132 · see citing works
Lysine Hydroxylation and Cross-linking of Collagen
Yamauchi, M., & Shiiba, M. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-084-7_7 · Cited by 129 · see citing works
Self-citationChen, H. C., & Guan, J. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47413-3 · Cited by 128 · see citing works
Atsawasuwan, P., Mochida, Y., Katafuchi, M., Kaku, M., Fong, K. S. K., Csiszár, K., & Yamauchi, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803142200 · Cited by 128 · see citing works
Self-citationCoevolution of cancer and stromal cellular responses
Littlepage, L. E., Egeblad, M., & Werb, Z. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.019 · Cited by 125 · see citing works
Self-citationLe, Q., Kong, C. S., Lavori, P. W., O'Byrne, K. J., Erler, J. T., Huang, X., Chen, Y., Cao, H., Tibshirani, R. J., Denko, N., et al. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.01.071 · Cited by 119 · see citing works
Self-citationThe Heritability of Mammographically Dense and Nondense Breast Tissue
Stone, J. L., Dite, G. S., Gunasekara, A., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0127 · Cited by 118 · see citing works
Lysyl oxidase in development, aging and pathologies of the skin
Szauter, K. M., Cao, T., Boyd, C. D., & Csiszár, K. (2005) · Pathologie Biologie · doi:10.1016/j.patbio.2004.12.033 · Cited by 115 · see citing works
Min, C., Kirsch, K. H., Zhao, Y., Jeay, S., Palamakumbura, A. H., Trackman, P. C., & Sonenshein, G. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3867 · Cited by 110 · see citing works
van der Slot, A. J., van Dura, E. A., de Wit, E. C., DeGroot, J., Huizinga, T. W. J., Bank, R. A., & Zuurmond, A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.009 · Cited by 104 · see citing works
Risk of pancreatic cancer in patients with cystic fibrosis: Table 1
Maisonneuve, P., Marshall, B. C., & Lowenfels, A. B. (2007) · Gut · doi:10.1136/gut.2007.125278 · Cited by 96 · see citing works
Decitre, M., Gleyzal, C., Raccurt, M., Peyrol, S., Aubert‐Foucher, E., Csiszár, K., & Sommer, P. (1998) · PubMed · Cited by 94 · see citing works
Madan, R., Smolkin, M. B., Cocker, R. S., Fayyad, R. S., & Oktay, M. H. (2005) · Human Pathology · doi:10.1016/j.humpath.2005.09.024 · Cited by 90 · see citing works
Friedland, J. C., Lakins, J. N., Kazanietz, M. G., Chernoff, J., Boettiger, D. E., & Weaver, V. M. (2007) · Journal of Cell Science · doi:10.1242/jcs.03484 · Cited by 89 · see citing works
Self-citationHypoxia/reoxygenation: A dynamic regulator of lysyl oxidase‐facilitated breast cancer migration
Postovit, L.-M. M., Abbott, D. E., Raimondi, S. L., Wheaton, W. W., Margaryan, N. V., Sullivan, R., Jansen, M. K., Csiszár, K., Hendrix, M. J. C., & Kirschmann, D. A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21517 · Cited by 88 · see citing works
den Eynden, G. G. V., Colpaert, C., Couvelard, A., et al. (2007) · Histopathology · doi:10.1111/j.1365-2559.2007.02761.x · Cited by 88 · see citing works
Demystifying the Effects of a Three‐Dimensional Microenvironment in Tissue Morphogenesis
Levental, K. R., Leight, J. L., & Weaver, V. M. (2007) · Methods in cell biology · doi:10.1016/s0091-679x(07)83023-8 · Cited by 87 · see citing works
Self-citationMultifaceted Roles of Integrins in Breast Cancer Metastasis
White, D. E., & Muller, W. J. (2007) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-007-9045-5 · Cited by 85 · see citing works
The Mechanical Properties of Skin in Osteogenesis Imperfecta
Hansen, B. R., & Jemec, G. B. E. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.7.909 · Cited by 84 · see citing works
Dalberg, K., Eriksson, E. T., Enberg, U., et al. (2000) · World Journal of Surgery · doi:10.1007/s002689910053 · Cited by 81 · see citing works
CD98hc (SLC3A2) Interaction with β1 Integrins Is Required for Transformation
Henderson, N. C., Collis, E., MacKinnon, A. C., Simpson, K. J., Haslett, C., Zent, R., Ginsberg, M. H., & Sethi, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408700200 · Cited by 80 · see citing works
CHANGES IN COLLAGEN METABOLISM IN PROSTATE CANCER: A HOST RESPONSE THAT MAY ALTER PROGRESSION
Burns‐Cox, N., Avery, N. C., Gingell, J. C., et al. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65656-x · Cited by 78 · see citing works
Ylisirniö, S., Höyhtyä, M., Mäkitaro, R., et al. (2001) · PubMed · Cited by 76 · see citing works
Koukoulis, G. Κ., Howeedy, A. A., Korhonen, M. O., et al. (1993) · PubMed · Cited by 76 · see citing works
beta1 integrin as a molecular therapeutic target
Cordes, N., & Park, C. C. (2007) · International Journal of Radiation Biology · doi:10.1080/09553000701639694 · Cited by 73 · see citing works
Simulating Properties of In Vitro Epithelial Cell Morphogenesis
Grant, M. R., Mostov, K. E., Tlsty, T. D., et al. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020129 · Cited by 73 · see citing works
Pfeiffer, B. J., Franklin, C. L., Hsieh, F.-H., et al. (2005) · Matrix Biology · doi:10.1016/j.matbio.2005.07.001 · Cited by 70 · see citing works
Hasebe, T., Tsuda, H., Tsubono, Y., Imoto, S., & Mukai, K. (1997) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1997.tb00423.x · Cited by 70 · see citing works
Hughes, S., Agbaje, O. F., Bowen, R. L., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0884 · Cited by 68 · see citing works
Zhao, Y., Min, C., Vora, S. R., Trackman, P. C., Sonenshein, G. E., & Kirsch, K. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802612200 · Cited by 65 · see citing works
Oleggini, R., GASTALDO, N., & DiDonato, A. J. (2007) · Matrix Biology · doi:10.1016/j.matbio.2007.02.003 · Cited by 64 · see citing works
Zaman, M. H., Matsudaira, P. T., & Lauffenburger, D. A. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-006-9205-6 · Cited by 59 · see citing works
Zutter, M. M., Sun, H. Y., & Santoro, S. A. (1998) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1018798907544 · Cited by 54 · see citing works
Type I and III collagen metabolites as predictors of clinical outcome in epithelial ovarian cancer.
Santala, M., Simojoki, M., Risteli, J., et al. (1999) · PubMed · Cited by 53 · see citing works
Stroma: Tumor Agonist or Antagonist
Proia, D. A., & Kuperwasser, C. (2005) · Cell Cycle · doi:10.4161/cc.4.8.1903 · Cited by 52 · see citing works
Chibon, F., de Mascarel, I., Sierankowski, G., et al. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.195 · Cited by 52 · see citing works
Altered Posttranslational Modifications of Collagen in Keloid
Uzawa, K., Marshall, M. K., Katz, E. P., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8955 · Cited by 47 · see citing works
den Eynden, G. G. V., Smid, M., Laere, S. V., Colpaert, C., der Auwera, I. V., Trinh, X. B., van Dam, P. A., den Bakker, M. A., Dirix, L. Y., Marck, E. A. V., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4397 · Cited by 37 · see citing works
PALPATION IMAGING USING A HAPTIC SYSTEM FOR VIRTUAL REALITY APPLICATIONS IN MEDICINE
Khaled, W., Reichling, S., Bruhns, O. T., et al. (2004) · doi:10.1142/9789812702678_0055 · Cited by 36 · see citing works
Kim, D. J., Lee, D. C., Yang, S.-J., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.071 · Cited by 34 · see citing works
The Tissue Microenvironment as an Epigenetic Tumor Modifier
Unger, M. A., & Weaver, V. M. (2003) · Humana Press eBooks · doi:10.1385/1-59259-329-1:315 · Cited by 19 · see citing works
Self-citationKoslowski, R., Pfeil, U., Fehrenbach, H., et al. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.00085601 · Cited by 19 · see citing works
Early Prediction of Severity in Acute Pancreatitis Using Infrared Spectroscopy of Serum
Petrov, M. S., Gordetzov, A. S., & Kukosh, M. V. (2007) · Pancreatology · doi:10.1159/000108961 · Cited by 18 · see citing works
Introduction: Signaling in Mammary Development and Tumorigenesis
Muller, W. J., & Neville, M. C. (2001) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1009540813521 · Cited by 17 · see citing works
Biochemical Characterization of Collagen in Alveolar Mucosa and Attached Gingiva of Pig
Katafuchi, M., Matsuura, T., Atsawasuwan, P., et al. (2007) · Connective Tissue Research · doi:10.1080/03008200601143508 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151 · see citing works
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · see citing works
Remodelling the extracellular matrix in development and disease
Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3904 · Cited by 4,367 · see citing works
The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works
The extracellular matrix at a glance
Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334 · see citing works
Self-citationTumor Metastasis: Molecular Insights and Evolving Paradigms
Valastyan, S., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.024 · Cited by 4,011 · see citing works
The extracellular matrix: A dynamic niche in cancer progression
Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201102147 · Cited by 3,024 · see citing works
Self-citationExtracellular matrix structure
Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.001 · Cited by 2,598 · see citing works
Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290 · see citing works
Extracellular Matrix Degradation and Remodeling in Development and Disease
Lu, P., Takai, K., Weaver, V. M., & Werb, Z. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005058 · Cited by 2,265 · see citing works
Self-citationConcepts of extracellular matrix remodelling in tumour progression and metastasis
Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18794-x · Cited by 2,296 · see citing works
The tumor microenvironment at a glance
Balkwill, F. R., Capasso, M., & Hagemann, T. (2012) · Journal of Cell Science · doi:10.1242/jcs.116392 · Cited by 1,857 · see citing works
Pre-metastatic niches: organ-specific homes for metastases
Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889 · see citing works
Self-citationDeconstructing the third dimension – how 3D culture microenvironments alter cellular cues
Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760 · see citing works
Signaling mechanisms of the epithelial-mesenchymal transition
Gonzalez, D. M., & Medici, D. (2014) · Science Signaling · doi:10.1126/scisignal.2005189 · Cited by 1,721 · see citing works
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3726 · Cited by 1,520 · see citing works
Every step of the way: integrins in cancer progression and metastasis
Hamidi, H., & Ivaska, J. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0038-z · Cited by 1,493 · see citing works
Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478 · see citing works
FAK in cancer: mechanistic findings and clinical applications
Sulzmaier, F. J., Jean, C., & Schlaepfer, D. D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3792 · Cited by 1,381 · see citing works
Wolf, K., te Lindert, M., Krause, M., Alexander, S., te Riet, J., Willis, A. L., Hoffman, R. M., Figdor, C. G., Weiss, S. J., & Friedl, P. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201210152 · Cited by 1,375 · see citing works
Nanotechnological strategies for engineering complex tissues
Dvir, T., Timko, B. P., Kohane, D. S., & Langer, R. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.246 · Cited by 1,367 · see citing works
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346 · see citing works
Diversity and biology of cancer-associated fibroblasts
Biffi, G., & Tuveson, D. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00048.2019 · Cited by 1,265 · see citing works
Clinical and therapeutic relevance of cancer-associated fibroblasts
Chen, Y., McAndrews, K. M., & Kalluri, R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00546-5 · Cited by 1,230 · see citing works
Salmon, H., Franciszkiewicz, K., Damotte, D., Dieu-Nosjean, M.-C., Validire, P., Trautmann, A., Mami-Chouaib, F., & Donnadieu, E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45817 · Cited by 1,138 · see citing works
Immunological hallmarks of stromal cells in the tumour microenvironment
Turley, S. J., Cremasco, V., & Astarita, J. L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3902 · Cited by 1,140 · see citing works
Targeting the tumour stroma to improve cancer therapy
Valkenburg, K. C., de Groot, A. E., & Pienta, K. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0007-1 · Cited by 1,084 · see citing works
The Role of Mechanical Forces in Tumor Growth and Therapy
Jain, R. K., Martin, J. D., & Stylianopoulos, T. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105259 · Cited by 1,044 · see citing works
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985 · see citing works
Dynamic molecular processes mediate cellular mechanotransduction
Hoffman, B. D., Grashoff, C., & Schwartz, M. A. (2011) · Nature · doi:10.1038/nature10316 · Cited by 956 · see citing works
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
Stylianopoulos, T., Martin, J. D., Chauhan, V. P., Jain, S. R., Diop-Frimpong, B., Bardeesy, N., Smith, B. L., Ferrone, C. R., Hornicek, F. J., Boucher, Y., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213353109 · Cited by 943 · see citing works
Extracellular matrix and its therapeutic potential for cancer treatment
Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00544-0 · Cited by 962 · see citing works
Three-dimensional culture systems in cancer research: Focus on tumor spheroid model
Nath, S., & Devi, G. R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.03.013 · Cited by 919 · see citing works
Cancer stem cells as key drivers of tumour progression
Ayob, A. Z., & Ramasamy, T. S. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0426-4 · Cited by 910 · see citing works
How the ageing microenvironment influences tumour progression
Fane, M., & Weeraratna, A. T. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0222-9 · Cited by 849 · see citing works
Barry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870 · see citing works
Chaudhuri, O., Koshy, S. T., Branco da Cunha, C., Shin, J.-W., Verbeke, C. S., Allison, K. H., & Mooney, D. J. (2014) · Nature Materials · doi:10.1038/nmat4009 · Cited by 820 · see citing works
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer
Affo, S., Yu, L.-X., & Schwabe, R. F. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100322 · Cited by 757 · see citing works
Mechanobiology of collective cell behaviours
Ladoux, B., & Mège, R.-M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.98 · Cited by 749 · see citing works
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
Wu, F., Yang, J., Liu, J., Wang, Y., Mu, J., Zeng, Q., Deng, S., & Zhou, H. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00641-0 · Cited by 773 · see citing works
Fang, J., Islam, W., & Maeda, H. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.005 · Cited by 757 · see citing works
Schrader, J., Gordon-Walker, T. T., Aucott, R. L., van Deemter, M., Quaas, A., Walsh, S., Benten, D., Forbes, S. J., Wells, R. G., & Iredale, J. P. (2011) · Hepatology · doi:10.1002/hep.24108 · Cited by 720 · see citing works
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
Paszek, M. J., DuFort, C. C., Rossier, O., Bainer, R., Mouw, J. K., Godula, K., Hudak, J. E., Lakins, J. N., Wijekoon, A. C., Cassereau, L., et al. (2014) · Nature · doi:10.1038/nature13535 · Cited by 699 · see citing works
Self-citationBourboulia, D., & Stetler-Stevenson, W. G. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.05.002 · Cited by 710 · see citing works
Three-dimensional organotypic culture: experimental models of mammalian biology and disease
Shamir, E. R., & Ewald, A. J. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3873 · Cited by 719 · see citing works
Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics
Guvendiren, M., & Burdick, J. A. (2012) · Nature Communications · doi:10.1038/ncomms1792 · Cited by 707 · see citing works
Therapy for Fibrotic Diseases: Nearing the Starting Line
Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655 · see citing works
Collagen as a double-edged sword in tumor progression
Fang, M., Yuan, J., Peng, C., & Li, Y. (2014) · Tumor Biology · doi:10.1007/s13277-013-1511-7 · Cited by 580 · see citing works
Mechanoreciprocity in cell migration
van Helvert, S., Storm, C., & Friedl, P. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0012-0 · Cited by 587 · see citing works
Mechanisms Governing Metastatic Dormancy and Reactivation
Giancotti, F. G. (2013) · Cell · doi:10.1016/j.cell.2013.10.029 · Cited by 586 · see citing works
Chen, Y., Kim, J., Yang, S., Wang, H., Wu, C.-J., Sugimoto, H., LeBleu, V. S., & Kalluri, R. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.02.007 · Cited by 566 · see citing works
Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
Swartz, M. A., & Lund, A. W. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3186 · Cited by 544 · see citing works
The obese adipose tissue microenvironment in cancer development and progression
Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542 · see citing works
Improving drug delivery to solid tumors: Priming the tumor microenvironment
Khawar, I. A., Kim, J. H., & Kuh, H.-J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.018 · Cited by 533 · see citing works
Collagen VI regulates satellite cell self-renewal and muscle regeneration
Urciuolo, A., Quarta, M., Morbidoni, V., Gattazzo, F., Molon, S., Grumati, P., Montemurro, F., Tedesco, F. S., Blaauw, B., Cossu, G., et al. (2013) · Nature Communications · doi:10.1038/ncomms2964 · Cited by 511 · see citing works
Karagiannis, G. S., Poutahidis, T., Erdman, S. E., Kirsch, R., Riddell, R. H., & Diamandis, E. P. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0307 · Cited by 507 · see citing works
Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer
Buechler, M. B., Fu, W., & Turley, S. J. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.021 · Cited by 494 · see citing works
The extracellular matrix in breast cancer
Insua-Rodríguez, J., & Oskarsson, T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.017 · Cited by 470 · see citing works
Fibrosis-dependent mechanisms of hepatocarcinogenesis
Zhang, D. Y., & Friedman, S. L. (2012) · Hepatology · doi:10.1002/hep.25670 · Cited by 444 · see citing works
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
Dupont, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.034 · Cited by 449 · see citing works
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Wong, C. C.-L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C.-M., Khoo, U.-S., Ng, I. O.-L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113483108 · Cited by 437 · see citing works
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.03.012 · Cited by 416 · see citing works
Tumor Microenvironment and Differential Responses to Therapy
Hirata, E., & Sahai, E. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026781 · Cited by 422 · see citing works
Dudley, A. C. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006536 · Cited by 424 · see citing works
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment
Gu, L., & Mooney, D. J. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.3 · Cited by 407 · see citing works
YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth
Low, B. C., Pan, C. Q., Shivashankar, G. V., Bershadsky, A., Sudol, M., & Sheetz, M. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.012 · Cited by 412 · see citing works
Wells, R. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.007 · Cited by 384 · see citing works
RAP2 mediates mechanoresponses of the Hippo pathway
Meng, Z., Qiu, Y., Lin, K. C., Kumar, A., Placone, J. K., Fang, C., Wang, K.-C., Lu, S., Pan, M., Hong, A. W., et al. (2018) · Nature · doi:10.1038/s41586-018-0444-0 · Cited by 377 · see citing works
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy
Bertero, T., Oldham, W. M., Grasset, E. M., Bourget, I., Boulter, E., Pisano, S., Hofman, P., Bellvert, F., Meneguzzi, G., Bulavin, D. V., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.012 · Cited by 393 · see citing works
Bhattacharjee, S., Hamberger, F., Ravichandra, A., Miller, M., Nair, A., Affo, S., Filliol, A., Chin, L., Savage, T. M., Yin, D., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146987 · Cited by 367 · see citing works
Mesenchymal stem/stromal cells in cancer therapy
Lan, T., Luo, M., & Wei, X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01208-w · Cited by 374 · see citing works
Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs
Hall, M. S., Alisafaei, F., Ban, E., Feng, X., Hui, C.-Y., Shenoy, V. B., & Wu, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613058113 · Cited by 360 · see citing works
The Role of the Extracellular Matrix in Cancer Stemness
Nallanthighal, S., Heiserman, J. P., & Cheon, D.-J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00086 · Cited by 344 · see citing works
Adipocyte-derived endotrophin promotes malignant tumor progression
Park, J., & Scherer, P. E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63930 · Cited by 350 · see citing works
Mechanisms and impact of altered tumour mechanics
Mohammadi, H., & Sahai, E. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0131-2 · Cited by 336 · see citing works
Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression
Brassart-Pasco, S., Brézillon, S., Brassart, B., Ramont, L., Oudart, J.-B., & Monboisse, J. C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00397 · Cited by 335 · see citing works
Engineering cancer microenvironments for in vitro 3-D tumor models
Asghar, W., El Assal, R., Shafiee, H., Pitteri, S., Paulmurugan, R., & Demirci, U. (2015) · Materials Today · doi:10.1016/j.mattod.2015.05.002 · Cited by 316 · see citing works
Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers
Wang, H., Abhilash, A. S., Chen, C. S., Wells, R. G., & Shenoy, V. B. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.09.044 · Cited by 313 · see citing works
RETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3963 · Cited by 296 · see citing works
RetractedChen, J.-H., & Simmons, C. A. (2011) · Circulation Research · doi:10.1161/circresaha.110.234237 · Cited by 289 · see citing works
Cell Elasticity Determines Macrophage Function
Patel, N. R., Bole, M., Chen, C., Hardin, C. C., Kho, A. T., Mih, J., Deng, L., Butler, J., Tschumperlin, D., Fredberg, J. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041024 · Cited by 275 · see citing works
Engineering and physical sciences in oncology: challenges and opportunities
Mitchell, M. J., Jain, R. K., & Langer, R. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.83 · Cited by 273 · see citing works
Role of hypoxia-inducible factors in breast cancer metastasis
Gilkes, D. M., & Semenza, G. L. (2013) · Future Oncology · doi:10.2217/fon.13.92 · Cited by 274 · see citing works
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Fan, W., Adebowale, K., Váncza, L., Li, Y., Rabbi, M. F., Kunimoto, K., Chen, D., Mozes, G., Chiu, D. K.-C., Li, Y., et al. (2024) · Nature · doi:10.1038/s41586-023-06991-9 · Cited by 263 · see citing works
Extracellular matrix stiffness: Mechanisms in tumor progression and therapeutic potential in cancer
Zhang, M., & Zhang, B. (2025) · Experimental Hematology & Oncology · doi:10.1186/s40164-025-00647-2 · Cited by 269 · see citing works
“For example, breast cancer cells under high tension can enhance integrin-dependent mechanical signaling through the expression of FAK or p130cas, which are two integrin-adhesion focal proteins, and promote the progression of breast tumors [39].”
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0629 · Cited by 252 · see citing works
RetractedVan De Water, L., Varney, S., & Tomasek, J. J. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0393 · Cited by 251 · see citing works
Roles of PLODs in Collagen Synthesis and Cancer Progression
Qi, Y., & Xu, R. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00066 · Cited by 248 · see citing works
Biophysics of tumor microenvironment and cancer metastasis – a mini review
Emon, B., Bauer, J., Jain, Y., Jung, B., & Saif, T. (2018) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2018.07.003 · Cited by 245 · see citing works
Multi-component extracellular matrices based on peptide self-assembly
Collier, J. H., Rudra, J. S., Gasiorowski, J. Z., & Jung, J. P. (2010) · Chemical Society Reviews · doi:10.1039/b914337h · Cited by 229 · see citing works
Skardal, A., Devarasetty, M., Forsythe, S., Atala, A., & Soker, S. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.25950 · Cited by 230 · see citing works
TGF-β Synergizes with Defects in the Hippo Pathway to Stimulate Human Malignant Mesothelioma Growth
Fujii, M., Toyoda, T., Nakanishi, H., Yatabe, Y., Sato, A., Matsudaira, Y., Ito, H., Murakami, H., Kondo, Y., Kondo, E., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20111653 · Cited by 224 · see citing works
Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis
Chiodoni, C., Colombo, M. P., & Sangaletti, S. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9221-8 · Cited by 221 · see citing works
A microengineered pathophysiological model of early-stage breast cancer
Choi, Y., Hyun, E., Seo, J., Blundell, C., Kim, H. C., Lee, E., Lee, S. H., Moon, A., Moon, W. K., & Huh, D. (2015) · Lab on a Chip · doi:10.1039/c5lc00514k · Cited by 222 · see citing works
Bioengineering Approaches for the Advanced Organoid Research
Yi, S. A., Zhang, Y., Rathnam, C., Pongkulapa, T., & Lee, K. (2021) · Advanced Materials · doi:10.1002/adma.202007949 · Cited by 218 · see citing works
Foster, C. T., Gualdrini, F., & Treisman, R. (2017) · Genes & Development · doi:10.1101/gad.304501.117 · Cited by 202 · see citing works
Carcinoma‐associated fibroblasts: Non‐neoplastic tumour‐promoting mesenchymal cells
Polanska, U. M., & Orimo, A. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24347 · Cited by 208 · see citing works
Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts
Avery, D., Govindaraju, P., Jacob, M., Todd, L., Monslow, J., & Puré, E. (2018) · Matrix Biology · doi:10.1016/j.matbio.2017.12.003 · Cited by 206 · see citing works
Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer
Takai, K., Le, A., Weaver, V. M., & Werb, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.12658 · Cited by 207 · see citing works
Self-citation
- Authors
- Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., Yamauchi, M., Gasser, D. L., & Weaver, V. M.
- Affiliations
- University of Pennsylvania (US)
- University of California, San Francisco (US)
- Stanford Medicine (US)
- University of Hawaiʻi at Mānoa (US)
- The Wistar Institute (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Weaver, Valerie M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 139
- Issue
- 5
- Pages
- 891-906
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2788004
- OpenAlex
- W2100303404
- Cited by
- 4,101
- References
- 156
- Citations by year
- 2026: 237 · 2025: 225 · 2024: 232 · 2023: 263 · 2022: 289 · 2021: 327 · 2020: 327 · 2019: 269 · 2018: 269 · 2017: 270 · 2016: 260 · 2015: 219 · 2014: 249 · 2013: 241 · 2012: 192
- FWCI
- 62.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- Conicet (submittedVersion, cc-by-nc-sa)
- UNC Libraries
- Funders
- U.S. Department of Defense (W81XWH, W81XWH-05-1-330)
- U.S. Department of Energy
- Ministerio de Economía y Competitividad
- National Institutes of Health (W81XWH)
- National Heart, Lung, and Blood Institute (T32HL007954, T32HL00795404)
- National Cancer Institute (R01CA138818, U54CA143836, R01CA078731, R01CA057621)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- collagen cross-linking, extracellular matrix stiffness, tumor progression, breast cancer, integrin signaling, focal adhesions, PI3K signaling, lysyl oxidase, fibrosis, tumor invasion, MMTV-neu, extracellular matrix remodeling
- MeSH terms
- Aging, Animals, Breast Neoplasms, Collagen, Epidermal Growth Factor, Extracellular Matrix, Female, Fibrosis, Humans, Protein-Lysine 6-Oxidase, Mice, Inbred BALB C, Genes, ras, Signal Transduction, Integrins, Mammary Glands, Human, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
