The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity
Open accessAbstract
In recent years, significant progress has been made in understanding cardiomyocyte differentiation. However, little is known about the regulation of myocyte survival despite the fact that myocyte apoptosis is a leading cause of heart failure. Here we report that transcription factor GATA-4 is a survival factor for differentiated, postnatal cardiomyocytes and an upstream activator of the antiapoptotic gene Bcl-X. An early event in the cardiotoxic effect of the antitumor drug doxorubicin is GATA-4 depletion, which in turn causes cardiomyocyte apoptosis. Mouse heterozygotes for a null Gata4 allele have enhanced susceptibility to doxorubicin cardiotoxicity. Genetic or pharmacologic enhancement of GATA-4 prevents cardiomyocyte apoptosis and drug-induced cardiotoxicity. The results indicate that GATA-4 is an antiapoptotic factor required for the adaptive stress response of the adult heart. Modulation of survival/apoptosis genes by tissue-specific transcription factors may be a general paradigm that can be exploited effectively for cell-specific regulation of apoptosis in disease states.
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Cites
The Bcl2 family: regulators of the cellular life-or-death switch
Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673
A mechanistic role for cardiac myocyte apoptosis in heart failure
Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., & Kitsis, R. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17664 · Cited by 765
Stewart, J. M., Munoz, J., & Weldon, A. (2002) · Circulation · doi:10.1161/01.cir.0000040999.00692.f3 · Cited by 71
Cited by
Rawat, P. S., Jaiswal, A., Khurana, A., Bhatti, J. S., & Navik, U. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111708 · Cited by 909
Oka, T., Maillet, M., Watt, A. J., Schwartz, R. J., Aronow, B. J., Duncan, S. A., & Molkentin, J. D. (2006) · Circulation Research · doi:10.1161/01.res.0000215985.18538.c4 · Cited by 423
Self-citationZhao, L., & Zhang, B. (2017) · Scientific Reports · doi:10.1038/srep44735 · Cited by 375
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis
Rodrigues, N. P. (2005) · Blood · doi:10.1182/blood-2004-08-2989 · Cited by 297
Role of the GATA Family of Transcription Factors in Endocrine Development, Function, and Disease
Viger, R. S., Guittot, S. M., Anttonen, M., Wilson, D. B., & Heikinheimo, M. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0513 · Cited by 270
Metadata
- Authors
- Aries, A., Paradis, P., Lefebvre, C., Schwartz, R. J., & Nemer, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-04-20
- Volume
- 101
- Issue
- 18
- Pages
- 6975-6980
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2124126928
- Cited by
- 296
- References
- 4
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
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