The Bcl2 family: regulators of the cellular life-or-death switch

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289 · see citing works

Caspases: Enemies Within

Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857 · see citing works

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003 · see citing works

The Bcl-2 Protein Family: Arbiters of Cell Survival

Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,303 · see citing works

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

Yang, J., Liu, X., Bhalla, K. N., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X. (1997) · Science · doi:10.1126/science.275.5303.1129 · Cited by 4,913 · see citing works

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715 · see citing works

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445 · see citing works

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

Wei, M. C., Zong, W.-X., Cheng, E. H.-Y., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., & Korsmeyer, S. J. (2001) · Science · doi:10.1126/science.1059108 · Cited by 3,988 · see citing works

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626 · see citing works

BCL-2 family members and the mitochondria in apoptosisPreprint

Gross, A., McDonnell, J. M., & Korsmeyer, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.15.1899 · Cited by 3,623 · see citing works

RNA interference

Hannon, G. J. (2002) · Nature · doi:10.1038/418244a · Cited by 3,583 · see citing works

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

Vaux, D., Cory, S., & Adams, J. (1988) · Nature · doi:10.1038/335440a0 · Cited by 3,355 · see citing works

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,262 · see citing works

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145 · see citing works

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

Zha, J., Harada, H., Yang, E., Jockel, J., & Korsmeyer, S. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81382-3 · Cited by 2,578 · see citing works

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Ji, Y. (1993) · Cell · doi:10.1016/0092-8674(93)90485-9 · Cited by 2,497 · see citing works

Untitled work

(2001) · PubMed · Cited by 2,381 · see citing works

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315 · see citing works

Apoptosis

Johnstone, R. W., Ruefli, A. A., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00625-6 · Cited by 2,236 · see citing works

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N. (2000) · Science · doi:10.1126/science.288.5468.1053 · Cited by 2,112 · see citing works

Mechanisms of Caspase Activation and Inhibition during Apoptosis

Shi, Y. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00482-3 · Cited by 1,824 · see citing works

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

Cheng, E. H. Y., Wei, M. C., Weiler, S., Flavell, R. A., Mak, T. W., Lindsten, T., & Korsmeyer, S. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00320-3 · Cited by 1,708 · see citing works

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

Kuida, K., Haydar, T. F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P., & Flavell, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81476-2 · Cited by 1,643 · see citing works

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Novack, D. V., Sorenson, C. M., Shutter, J. R., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80065-m · Cited by 1,628 · see citing works

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

Bouillet, P., Metcalf, D., Huang, D. C. S., Tarlinton, D. M., Kay, T. W. H., Köntgen, F., Adams, J. M., & Strasser, A. (1999) · Science · doi:10.1126/science.286.5445.1735 · Cited by 1,504 · see citing works

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

Lindsten, T., Ross, A. J., King, A., Zong, W.-X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00136-2 · Cited by 1,489 · see citing works

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

Sattler, M., Liang, H., Nettesheim, D., Meadows, R. P., Harlan, J. E., Eberstadt, M., Yoon, H. S., Shuker, S. B., Chang, B. S., Minn, A. J., et al. (1997) · Science · doi:10.1126/science.275.5302.983 · Cited by 1,476 · see citing works

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

Muchmore, S. W., Sattler, M., Liang, H., Meadows, R. P., Harlan, J. E., Yoon, H. S., Nettesheim, D. G., Chang, B. S., Thompson, C. B., Wong, S., et al. (1996) · Nature · doi:10.1038/381335a0 · Cited by 1,467 · see citing works

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB

Baldwin, A. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11991 · Cited by 1,427 · see citing works

Apoptosis Signaling

Strasser, A., O’Connor, L., & Dixit, V. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.217 · Cited by 1,369 · see citing works

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

Ashkenazi, A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc821 · Cited by 1,351 · see citing works

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

Rampino, N. J., Yamamoto, H., Ionov, Y., Li, Y., Sawai, H., Reed, J. C., & Perucho, M. (1997) · Science · doi:10.1126/science.275.5302.967 · Cited by 1,326 · see citing works

Apoptosis in cancer therapy: Crossing the threshold

Fisher, D. E. (1994) · Cell · doi:10.1016/0092-8674(94)90518-5 · Cited by 1,315 · see citing works

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kägi, D., Khoo, W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81477-4 · Cited by 1,284 · see citing works

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W., & Vogelstein, B. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00213-1 · Cited by 1,282 · see citing works

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome cPreprint

Wei, M. C., Lindsten, T., Mootha, V. K., Weiler, S., Gross, A., Ashiya, M., Thompson, C. B., & Korsmeyer, S. J. (2000) · Genes & Development · doi:10.1101/gad.14.16.2060 · Cited by 1,265 · see citing works

A matter of life and death

Green, D. R., & Evan, G. I. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00024-7 · Cited by 1,254 · see citing works

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD‐specific caspase activation and independently of mitochondrial transmembrane depolarization

Bossy‐Wetzel, E., Newmeyer, D. D., & Green, D. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.37 · Cited by 1,225 · see citing works

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213 · see citing works

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

Wang, J., Liu, D., Zhang, Z., Shan, S., Han, X., Srinivasula, S. M., Croce, C. M., Alnemri, E. S., & Huang, Z. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7124 · Cited by 1,201 · see citing works

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

Sentman, C. L., Shutter, J. R., Hockenbery, D. M., Kanagawa, O., & Korsmeyer, S. J. (1991) · Cell · doi:10.1016/0092-8674(91)90361-2 · Cited by 1,194 · see citing works

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

Hengartner, M. O., & Horvitz, H. R. (1994) · Cell · doi:10.1016/0092-8674(94)90506-1 · Cited by 1,167 · see citing works

Cross-Talk between Two Cysteine Protease Families

Nakagawa, T., & Yuan, J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.4.887 · Cited by 1,164 · see citing works

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., et al. (1995) · Science · doi:10.1126/science.7878471 · Cited by 1,164 · see citing works

Bim: a novel member of the Bcl‐2 family that promotes apoptosis

O’Connor, L., Strasser, A., O’Reilly, L. A., Hausmann, G., Adams, J. M., Cory, S., & Huang, D. C. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.384 · Cited by 1,163 · see citing works

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

Yoshida, H., Kong, Y., Yoshida, R., Elia, A., Hakem, A., Hakem, R., Penninger, J. M., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81733-x · Cited by 1,138 · see citing works

Structure of Bax

Suzuki, M., Youle, R. J., & Tjandra, N. (2000) · Cell · doi:10.1016/s0092-8674(00)00167-7 · Cited by 1,104 · see citing works

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

Strasser, A., Harris, A. W., & Cory, S. (1991) · Cell · doi:10.1016/0092-8674(91)90362-3 · Cited by 1,054 · see citing works

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

Puthalakath, H., Huang, D. C. S., O'REILLY, L. A., King, S. M., & Strasser, A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80456-6 · Cited by 1,053 · see citing works

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

Huang, D. C. S., & Strasser, A. (2000) · Cell · doi:10.1016/s0092-8674(00)00187-2 · Cited by 1,044 · see citing works

The mitochondrion in apoptosis: how Pandora's box opens

Zamzami, N., & Kroemer, G. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35048073 · Cited by 1,029 · see citing works

Inhibition of Bax Channel-Forming Activity by Bcl-2

Antonsson, B. E., Conti, F., Ciavatta, A., Montessuit, S., Lewis, S., Martinou, I., Bernasconi, L., Bernard, A., Mermod, J., Mazzei, G. J., et al. (1997) · Science · doi:10.1126/science.277.5324.370 · Cited by 1,028 · see citing works

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

Yin, X.-M., Wang, K., Gross, A., Zhao, Y., Zinkel, S., Klocke, B., Roth, K. A., & Korsmeyer, S. J. (1999) · Nature · doi:10.1038/23730 · Cited by 1,004 · see citing works

The INK4a/ARF network in tumour suppression

Sherr, C. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096061 · Cited by 984 · see citing works

Breaking the mitochondrial barrier

Martinou, J., & Green, D. R. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35048069 · Cited by 951 · see citing works

BID: a novel BH3 domain-only death agonist.Preprint

Wang, K., Yin, X., Chao, D. T., Milliman, C. L., & Korsmeyer, S. J. (1996) · Genes & Development · doi:10.1101/gad.10.22.2859 · Cited by 941 · see citing works

Three-Dimensional Structure of the Apoptosome

Acehan, D., Jiang, X., Morgan, D. G., Heuser, J. E., Wang, X., & Akey, C. W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00442-2 · Cited by 912 · see citing works

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

Strasser, A., Harris, A. W., Bath, M. L., & Cory, S. (1990) · Nature · doi:10.1038/348331a0 · Cited by 905 · see citing works

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

Cecconi, F., Álvarez-Bolado, G., Meyer, B. I., Roth, K. A., & Gruß, P. (1998) · Cell · doi:10.1016/s0092-8674(00)81732-8 · Cited by 894 · see citing works

Life-or-death decisions by the Bcl-2 protein family

Adams, J. M., & Cory, S. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01740-0 · Cited by 887 · see citing works

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

McDonnell, T. J., & Korsmeyer, S. J. (1991) · Nature · doi:10.1038/349254a0 · Cited by 877 · see citing works

Role of <i>BAX</i> in the Apoptotic Response to Anticancer Agents

Zhang, L., Yu, J., Park, B. H., Kinzler, K. W., & Vogelstein, B. (2000) · Science · doi:10.1126/science.290.5493.989 · Cited by 863 · see citing works

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

Strasser, A., Whittingham, S., Vaux, D. L., Bath, M. L., Adams, J. M., Cory, S., & Harris, A. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8661 · Cited by 861 · see citing works

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and BakPreprint

Zong, W., Lindsten, T., Ross, A. J., MacGregor, G. R., & Thompson, C. B. (2001) · Genes & Development · doi:10.1101/gad.897601 · Cited by 809 · see citing works

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Flores, E. R., Tsai, K. Y., Crowley, D. G., Sengupta, S., Yang, A., McKeon, F., & Jacks, T. (2002) · Nature · doi:10.1038/416560a · Cited by 801 · see citing works

Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.

Strasser, A., Harris, A. W., Huang, D. C., Krammer, P. H., & Cory, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00304.x · Cited by 784 · see citing works

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

Bouillet, P., Purton, J. F., Godfrey, D. I., Zhang, L.-C., Coultas, L., Puthalakath, H., Pellegrini, M., Cory, S., Adams, J. M., & Strasser, A. (2002) · Nature · doi:10.1038/415922a · Cited by 782 · see citing works

Conformation of the Bax C‐terminus regulates subcellular location and cell death

Nechushtan, A., Smith, C. L., Hsu, Y., & Youle, R. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2330 · Cited by 732 · see citing works

From bench to clinic with apoptosis-based therapeutic agents

Nicholson, D. W. (2000) · Nature · doi:10.1038/35037747 · Cited by 685 · see citing works

Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells

Antonsson, B. E., Montessuit, S., Sanchez, B., & Martinou, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010810200 · Cited by 676 · see citing works

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

Strasser, A. (1994) · Cell · doi:10.1016/0092-8674(94)90201-1 · Cited by 665 · see citing works

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

Heiden, M. G. V., & Thompson, C. B. (1999) · Nature Cell Biology · doi:10.1038/70237 · Cited by 659 · see citing works

Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

Puthalakath, H., Villunger, A., O'Reilly, L. A., Beaumont, J. G., Coultas, L., Cheney, R. E., Huang, D. C. S., & Strasser, A. (2001) · Science · doi:10.1126/science.1062257 · Cited by 656 · see citing works

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

Yin, C., Knudson, C. M., Korsmeyer, S. J., & Dyke, T. V. (1997) · Nature · doi:10.1038/385637a0 · Cited by 650 · see citing works

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

Antonsson, B. E., Montessuit, S., Lauper, S., Eskes, R., & Martinou, J. (2000) · Biochemical Journal · doi:10.1042/bj3450271 · Cited by 646 · see citing works

The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9

Conradt, B., & Horvitz, H. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81182-4 · Cited by 642 · see citing works

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

Pelengaris, S., Khan, M., & Evan, G. I. (2002) · Cell · doi:10.1016/s0092-8674(02)00738-9 · Cited by 623 · see citing works

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

Vaux, D. L., Weissman, I. L., & Kim, S. K. (1992) · Science · doi:10.1126/science.1470921 · Cited by 614 · see citing works

Caspase-9 and APAF-1 form an active holoenzymePreprint

Rodriguez, J., & Lazebnik, Y. A. (1999) · Genes & Development · doi:10.1101/gad.13.24.3179 · Cited by 573 · see citing works

Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

Zha, J., Weiler, S., Oh, K. J., Wei, M. C., & Korsmeyer, S. J. (2000) · Science · doi:10.1126/science.290.5497.1761 · Cited by 559 · see citing works

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

Degterev, A., Lugovskoy, A. A., Cardone, M. H., Mulley, B., Wagner, G., Mitchison, T. J., & Yuan, J. (2001) · Nature Cell Biology · doi:10.1038/35055085 · Cited by 550 · see citing works

Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria

Guo, Y., Srinivasula, S. M., Druilhe, A., Fernandes‐Alnemri, T., & Alnemri, E. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108029200 · Cited by 521 · see citing works

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

Li, K., Li, Y., Shelton, J. M., Richardson, J. A., Spencer, E., Chen, Z. J., Wang, X., & Williams, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)80849-1 · Cited by 509 · see citing works

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

Hsu, Y., & Youle, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10777 · Cited by 504 · see citing works

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

Chou, J. J., Li, H., Salvesen, G. S., Yuan, J., & Wagner, G. (1999) · Cell · doi:10.1016/s0092-8674(00)80572-3 · Cited by 488 · see citing works

Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis Elegans

Horvitz, H. R. (1994) · Springer eBooks · doi:10.1007/978-1-4757-9217-1_1 · Cited by 486 · see citing works

Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

Griffiths, G. J., Dubrez, L., Morgan, C. P., Jones, N. A., Whitehouse, J., Corfe, B. M., Dive, C., & Hickman, J. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.5.903 · Cited by 479 · see citing works

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c‐independent apoptosis blocked by Bcl‐2

Li, P., Dietz, R., & von Harsdorf, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6027 · Cited by 478 · see citing works

Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

Nechushtan, A., Smith, C. L., Lamensdorf, I., Yoon, S., & Youle, R. J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.6.1265 · Cited by 477 · see citing works

Cardiolipin provides specificity for targeting of tBid to mitochondria

Lutter, M. L., Fang, M., Luo, X., Nishijima, M., Xie, X., & Wang, X. (2000) · Nature Cell Biology · doi:10.1038/35036395 · Cited by 472 · see citing works

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

Rao, R. V., Castro‐Obregón, S., Frankowski, H., Schüler, M., Stoka, V., del Rio, G., Bredesen, D. E., & Ellerby, H. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202726200 · Cited by 472 · see citing works

Solution structure of the antiapoptotic protein bcl-2

Petros, A. M., Medek, A., Nettesheim, D. G., Kim, D. H., Yoon, H. S., Swift, K. M., Matayoshi, E. D., Oltersdorf, T., & Fesik, S. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041619798 · Cited by 458 · see citing works

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

Tzung, S.-P., Kim, K. M., Basañez, G., Giedt, C. D., Simon, J., Zimmerberg, J., Zhang, K. Y. J., & Hockenbery, D. M. (2001) · Nature Cell Biology · doi:10.1038/35055095 · Cited by 452 · see citing works

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

Putcha, G. V., Moulder, K. L., Golden, J. P., Bouillet, P., Adams, J. A., Strasser, A., & Johnson, E. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00238-0 · Cited by 448 · see citing works

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

Saito, M. L., Korsmeyer, S. J., & Schlesinger, P. H. (2000) · Nature Cell Biology · doi:10.1038/35019596 · Cited by 445 · see citing works

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosisPreprint

Grumont, R. J., Rourke, I. J., & Gerondakis, S. (1999) · Genes & Development · doi:10.1101/gad.13.4.400 · Cited by 403 · see citing works

Mcl-1 deficiency results in peri-implantation embryonic lethality

Rinkenberger, J. L., Horning, S., Klocke, B., Roth, K., & Korsmeyer, S. J. (2000) · Genes &amp; Development · doi:10.1101/gad.14.1.23 · Cited by 397 · see citing works

Solution Structure of the Proapoptotic Molecule BID

McDonnell, J. M., Fushman, D., Milliman, C. L., Korsmeyer, S. J., & Cowburn, D. (1999) · Cell · doi:10.1016/s0092-8674(00)80573-5 · Cited by 396 · see citing works

The Role of Caspases in Development, Immunity, and Apoptotic Signal Transduction

Łoś, M., Wesselborg, S., & Schulze‐Osthoff, K. (1999) · Immunity · doi:10.1016/s1074-7613(00)80062-x · Cited by 392 · see citing works

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

McCurrach, M. E., Connor, T. M. F., Knudson, C. M., Korsmeyer, S. J., & Lowe, S. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2345 · Cited by 368 · see citing works

Caspases: their intracellular localization and translocation during apoptosis

Zhivotovsky, B., Afshin Samali, A., Gahm, A., & Orrenius, S. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400536 · Cited by 354 · see citing works

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

Ogilvy, S., Metcalf, D., Print, C. G., Bath, M. L., Harris, A. W., & Adams, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14943 · Cited by 341 · see citing works

VDAC regulation by the Bcl-2 family of proteins

Tsujimoto, Y., & Shimizu, S. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400780 · Cited by 338 · see citing works

Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant

Print, C. G., Loveland, K. L., Gibson, L., Meehan, T., Stylianou, A., Wreford, N. G., de Kretser, D., Metcalf, D., Köntgen, F., Adams, J. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12424 · Cited by 335 · see citing works

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

Mikhailov, V. M., Mikhailova, M., Pulkrabek, D., Dong, Z., Venkatachalam, M. A., & Saikumar, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100655200 · Cited by 324 · see citing works

The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance

Mayo, M. W., & Baldwin, A. S. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(00)00002-0 · Cited by 323 · see citing works

Granzyme B–Mediated Cytochrome C Release Is Regulated by the Bcl-2 Family Members Bid and Bax

Heibein, J. A., Goping, I. S., Barry, M., Pinkoski, M. J., Shore, G. C., Green, D. R., & Bleackley, R. C. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.10.1391 · Cited by 311 · see citing works

Apoptosomes: engines for caspase activation

Adams, J. M., & Cory, S. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00381-2 · Cited by 305 · see citing works

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

Häcki, J., Egger, L., Monney, L., Conus, S., Rossé, T., Fellay, I., & Borner, C. (2000) · Oncogene · doi:10.1038/sj.onc.1203592 · Cited by 300 · see citing works

Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX

Meijerink, J. P. P., Mensink, E. J. B. M., Wang, K., Sedlak, T. W., Sloetjes, A. W., de Witte, T., Waksman, G., & Korsmeyer, S. J. (1998) · Blood · doi:10.1182/blood.v91.8.2991.2991_2991_2997 · Cited by 286 · see citing works

Genetic analysis of chemoresistance in primary murine lymphomas

Schmitt, C. A., Rosenthal, C., & Lowe, S. W. (2000) · Nature Medicine · doi:10.1038/79542 · Cited by 280 · see citing works

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

Bouillet, P., Cory, S., Zhang, L., Strasser, A., & Adams, J. M. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00083-1 · Cited by 275 · see citing works

A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

Pavlov, E. V., Priault, M., Pietkiewicz, D., Cheng, E. H. Y., Antonsson, B. E., Manon, S., Korsmeyer, S. J., Mannella, C. A., & Kinnally, K. W. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200107057 · Cited by 273 · see citing works

Testicular degeneration in Bclw-deficient mice

Ross, A. J., Waymire, K. G., Moss, J. E., Parlow, A. F., Skinner, M. K., Russell, L. D., & MacGregor, G. R. (1998) · Nature Genetics · doi:10.1038/ng0398-251 · Cited by 268 · see citing works

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

Hu, Y., Ding, L., Spencer, D. M., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33489 · Cited by 256 · see citing works

Bak BH3 Peptides Antagonize Bcl-xL Function and Induce Apoptosis through Cytochrome c-independent Activation of Caspases

Holinger, E. P., Chittenden, T., & Lutz, R. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13298 · Cited by 254 · see citing works

Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

Ionov, Y., Yamamoto, H., Krajewski, S., Reed, J. C., & Perucho, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190210897 · Cited by 242 · see citing works

Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death

Chen, F., Hersh, B. M., Conradt, B., Zhou, Z., Riemer, D., Gruenbaum, Y., & Horvitz, H. R. (2000) · Science · doi:10.1126/science.287.5457.1485 · Cited by 237 · see citing works

Apoptosis Triggered by Myc-Induced Suppression of Bcl-X L or Bcl-2 Is Bypassed during Lymphomagenesis

Eischen, C. M., Woo, D. D. L., Roussel, M. F., & Cleveland, J. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5063-5070.2001 · Cited by 213 · see citing works

Upregulation of bcl‐2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines

Sartorius, U., & Krammer, P. H. (2001) · International Journal of Cancer · doi:10.1002/ijc.10096 · Cited by 206 · see citing works

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors.Preprint

Naik, P., Karrim, J., & Hanahan, D. (1996) · Genes & Development · doi:10.1101/gad.10.17.2105 · Cited by 204 · see citing works

The role of cytochrome c in caspase activation in Drosophila melanogaster cells

Dorstyn, L., Read, S. H., Cakouros, D., Huh, J. R., Hay, B. A., & Kumar, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200111107 · Cited by 204 · see citing works

Adult Apaf-1-Deficient Mice Exhibit Male Infertility

Honarpour, N., Du, C., Richardson, J. A., Hammer, R. E., Wang, X., & Herz, J. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9585 · Cited by 203 · see citing works

Bcl-2 family proteins as targets for anticancer drug design

Huang, Z. (2000) · Oncogene · doi:10.1038/sj.onc.1204087 · Cited by 201 · see citing works

Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2–related A1 Gene

Hamasaki, A., Sendo, F., Nakayama, K., Ishida, N., Negishi, I., Nakayama, K., & Hatakeyama, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.11.1985 · Cited by 199 · see citing works

Rapid Kinetics of tBid-induced Cytochrome c and Smac/DIABLO Release and Mitochondrial Depolarization

Madesh, M., Antonsson, B. E., Srinivasula, S. M., Alnemri, E. S., & Hajnóczky, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108171200 · Cited by 184 · see citing works

The role of ARK in stress-induced apoptosis in Drosophila cells

Zimmermann, K. C., Ricci, J., Droin, N. M., & Green, D. R. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.20112068 · Cited by 175 · see citing works

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

Strasser, A., Harris, A. W., & Cory, S. (1993) · PubMed · Cited by 165 · see citing works

tBID Homooligomerizes in the Mitochondrial Membrane to Induce Apoptosis

Grinberg, M., Sarig, R., Zaltsman, Y., Frumkin, D., Grammatikakis, N., Reuveny, E., & Gross, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m104893200 · Cited by 161 · see citing works

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

Moriishi, K., Huang, D. C. S., Cory, S., & Adams, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9683 · Cited by 160 · see citing works

Molecular Cloning of a Novel Polypeptide, DP5, Induced during Programmed Neuronal Death

Imaizumi, K., Tsuda, M., Imai, Y., Wanaka, A., Takagi, T., & Tohyama, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18842 · Cited by 160 · see citing works

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice

Jäger, R., Herzer, U., Schenkel, J., & Weiher, H. (1997) · Oncogene · doi:10.1038/sj.onc.1201353 · Cited by 159 · see citing works

Apoptotic Protease Activating Factor 1 (Apaf-1)–Independent Cell Death Suppression by Bcl-2

Haraguchi, M., Torii, S., Matsuzawa, S., Xie, Z., Kitada, S., Krajewski, S., Yoshida, H., Mak, T. W., & Reed, J. C. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.10.1709 · Cited by 158 · see citing works

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL

Hausmann, G., O’Reilly, L. A., van Driel, R. R., Beaumont, J. G., Strasser, A., Adams, J. M., & Huang, D. C. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.623 · Cited by 139 · see citing works

Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs

Baell, J. B., & Huang, D. C. S. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01148-6 · Cited by 136 · see citing works

The ‘harmless’ release of cytochrome c

von Ahsen, O., Waterhouse, N. J., Kuwana, T., Newmeyer, D. D., & Green, D. R. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400782 · Cited by 132 · see citing works

Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

Rytömaa, M., Lehmann, K. E., & Downward, J. (2000) · Oncogene · doi:10.1038/sj.onc.1203805 · Cited by 132 · see citing works

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus

Huang, Q., Petros, A. M., Virgin, H. W., Fesik, S. W., & Olejniczak, E. T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062525799 · Cited by 125 · see citing works

Assembly of Bcl-2 into microsomal and outer mitochondrial membranes

Janiak, F., Leber, B. F., & Andrews, D. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36960-0 · Cited by 123 · see citing works

Mutations of the bak gene in human gastric and colorectal cancers.

Kondo, S., Shinomura, Y., Miyazaki, Y., Kiyohara, T., Tsutsui, S., Kitamura, S., Nagasawa, Y., Nakahara, M., Kanayama, S., & Matsuzawa, Y. (2000) · PubMed · Cited by 122 · see citing works

Caspase-Dependent Cytosolic Release of Cytochrome c and Membrane Translocation of Bax in p53-Induced Apoptosis

Gao, C. F., Ren, S., Zhang, L., Nakajima, T., Ichinose, S., Hara, T., Koike, K., & Tsuchida, N. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5171 · Cited by 117 · see citing works

Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis

Rudner, J., Lepple‐Wienhues, A., Budach, W., Berschauer, J. E., Friedrich, B., Wesselborg, S., Schulze‐Osthoff, K., & Belka, C. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.23.4161 · Cited by 107 · see citing works

Bcl-2 Cooperates with Promyelocytic Leukemia Retinoic Acid Receptor α Chimeric Protein (Pmlrarα) to Block Neutrophil Differentiation and Initiate Acute Leukemia

Kogan, S. C., Brown, D. E., Shultz, D. B., Truong, B.-T., Lallemand-Breitenbach, V., Guillemin, M.-C., Lagasse, E., Weissman, I. L., & Bishop, J. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.531 · Cited by 107 · see citing works

Selective regulation ofBcl-XLby a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignanciesPreprint

Packham, G., White, E. L., Eischen, C. M., Yang, H. J., Parganas, E., Ihle, J. N., Grillot, D., Zambetti, G. P., Núñez, G., & Cleveland, J. L. (1998) · Genes & Development · doi:10.1101/gad.12.16.2475 · Cited by 102 · see citing works

Disruption of the CED-9/CED-4 Complex by EGL-1 is a Critical Step for Programmed Cell Death in C. elegans

del Peso, L., González, V. M., Inohara, N., Ellis, R. E., & Núñez, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000858200 · Cited by 67 · see citing works

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

Lee, S. T., Hoeflich, K. P., Wasfy, G. W., Woodgett, J. R., Leber, B. F., Andrews, D. W., Hedley, D. W., & Penn, L. Z. (1999) · Oncogene · doi:10.1038/sj.onc.1202716 · Cited by 65 · see citing works

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors

Parrish, J. Z., Metters, H., Chen, L., & Xue, D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.210391597 · Cited by 50 · see citing works

The Apoptotic Protease-Activating Factor 1-Mediated Pathway of Apoptosis Is Dispensable for Negative Selection of Thymocytes

Hara, H., Takeda, A., Takeuchi, M., Wakeham, A. C., Itié, A., Sasaki, M., Mak, T. W., Yoshimura, A., Nomoto, K., & Yoshida, H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.5.2288 · Cited by 48 · see citing works

Formation of noncanonical high molecular weight caspase-3 and -6 complexes and activation of caspase-12 during serum starvation induced apoptosis in AKR-2B mouse fibroblasts

Kilic, M., Schäfer, R., Hoppe, J., & Kagerhuber, U. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400968 · Cited by 44 · see citing works

Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1

Honarpour, N., Tabuchi, K., Stark, J. M., Hammer, R. E., Südhof, T. C., Parada, L. F., Wang, X., Richardson, J. A., & Herz, J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00275-5 · Cited by 20 · see citing works

Apoptosis: A Review of Programmed Cell Death

Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853 · see citing works

Mitochondrial membrane permeabilization in cell death

Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598 · see citing works

miR-15 and miR-16 induce apoptosis by targeting BCL2

Cimmino, A., Calin, G. A., Fabbri, M., Iorio, M. V., Ferracin, M., Shimizu, M., Wojcik, S. E., Aqeilan, R. I., Zupo, S., Dono, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506654102 · Cited by 3,510 · see citing works

Regulation of cell death: the calcium–apoptosis link

Orrenius, S., Zhivotovsky, B., & Nicotera, P. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1150 · Cited by 2,990 · see citing works

Anticancer activities of histone deacetylase inhibitors

Bolden, J. E., Peart, M. J., & Johnstone, R. W. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2133 · Cited by 2,919 · see citing works

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

Fulda, S., & Debatin, K.-M. (2006) · Oncogene · doi:10.1038/sj.onc.1209608 · Cited by 2,312 · see citing works

p53 in health and disease

Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,275 · see citing works

The Bcl-2 apoptotic switch in cancer development and therapy

Adams, J. M., & Cory, S. (2007) · Oncogene · doi:10.1038/sj.onc.1210220 · Cited by 2,178 · see citing works

The Role of Mitochondria in Apoptosis

Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134850 · Cited by 1,987 · see citing works

Molecular mechanisms of caspase regulation during apoptosis

Riedl, S. J., & Shi, Y. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1496 · Cited by 1,893 · see citing works

MicroRNA: Biogenesis, Function and Role in Cancer

MacFarlane, L.-A., & Murphy, P. R. (2010) · Current Genomics · doi:10.2174/138920210793175895 · Cited by 1,828 · see citing works

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819 · see citing works

Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

Arkin, M. R., & Wells, J. A. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1343 · Cited by 1,705 · see citing works

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

Sinha, K., Das, J., Pal, P. B., & Sil, P. C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1034-4 · Cited by 1,622 · see citing works

The Bcl-2 family: roles in cell survival and oncogenesis

Cory, S., Huang, D. C. S., & Adams, J. M. (2003) · Oncogene · doi:10.1038/sj.onc.1207102 · Cited by 1,455 · see citing works

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327 · see citing works

G1 cell-cycle control and cancer

Massagué, J. (2004) · Nature · doi:10.1038/nature03094 · Cited by 1,217 · see citing works

Validating survivin as a cancer therapeutic target

Altieri, D. C. (2003) · Nature reviews. Cancer · doi:10.1038/nrc968 · Cited by 1,204 · see citing works

DNA damage and repair

Friedberg, E. C. (2003) · Nature · doi:10.1038/nature01408 · Cited by 1,177 · see citing works

Apoptosis - the p53 network

Haupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136 · see citing works

Pathways of apoptotic and non-apoptotic death in tumour cells

Okada, H., & Mak, T. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1412 · Cited by 1,043 · see citing works

Toxic proteins released from mitochondria in cell death

Saelens, X., Festjens, N., Walle, L. V., van Gurp, M., Loo, G., & Vandenabeele, P. (2004) · Oncogene · doi:10.1038/sj.onc.1207523 · Cited by 977 · see citing works

A guide to cell death pathways

Yuan, J., & Ofengeim, D. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00689-6 · Cited by 972 · see citing works

Apoptosis and apoptotic body: disease message and therapeutic target potentials

Xu, X., Lai, Y., & Hua, Z. (2018) · Bioscience Reports · doi:10.1042/bsr20180992 · Cited by 923 · see citing works

Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Lu, H., Zhou, Q., He, J., Jiang, Z., Peng, C., Tong, R., & Shi, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00315-3 · Cited by 891 · see citing works

Broad targeting of resistance to apoptosis in cancer

Mohammad, R. M., Muqbil, I., Lowe, L. J., Yedjou, C. G., Hsu, H.-Y., Lin, L., Siegelin, M. D., Fimognari, C., Kumar, N. B., Dou, Q. P., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.001 · Cited by 876 · see citing works

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

Kim, H., Rafiuddin-Shah, M., Tu, H.-C., Jeffers, J. R., Zambetti, G. P., Hsieh, J. J.-D., & Cheng, E. H.-Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1499 · Cited by 874 · see citing works

VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis

Cheng, E. H.-Y., Sheiko, T. V., Fisher, J. K., Craigen, W. J., & Korsmeyer, S. J. (2003) · Science · doi:10.1126/science.1083995 · Cited by 852 · see citing works

Fuel feeds function: energy metabolism and the T-cell response

Fox, C. J., Hammerman, P. S., & Thompson, C. B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1710 · Cited by 841 · see citing works

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway

Feldstein, A. E., Werneburg, N. W., Canbay, A. E., Guicciardi, M. E., Bronk, S. F., Rydzewski, R. M., Burgart, L. J., & Gores, G. J. (2004) · Hepatology · doi:10.1002/hep.20283 · Cited by 833 · see citing works

VDAC, a multi-functional mitochondrial protein regulating cell life and death

Shoshan‐Barmatz, V., Pinto, V. D., Zweckstetter, M., Raviv, Z., Keinan, N., & Arbel, N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.03.002 · Cited by 792 · see citing works

Death receptor-induced cell killing

Thorburn, A. M. (2003) · Cellular Signalling · doi:10.1016/j.cellsig.2003.08.007 · Cited by 787 · see citing works

Ways of dying: multiple pathways to apoptosisPreprint

Adams, J. M. (2003) · Genes & Development · doi:10.1101/gad.1126903 · Cited by 776 · see citing works

Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

Leu, J. I.-J., Dumont, P., Hafey, M. J., Murphy, M. E., & George, D. L. (2004) · Nature Cell Biology · doi:10.1038/ncb1123 · Cited by 767 · see citing works

Life in the balance: how BH3-only proteins induce apoptosis

Willis, S. N., & Adams, J. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.10.001 · Cited by 743 · see citing works

Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival

Roderick, H. L., & Cook, S. J. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2374 · Cited by 731 · see citing works

Cell Death Pathways in Photodynamic Therapy of Cancer

Mróz, P., Yaroslavsky, A., Kharkwal, G. B., & Hamblin, M. R. (2011) · Cancers · doi:10.3390/cancers3022516 · Cited by 709 · see citing works

DNA damage-induced apoptosis

Norbury, C. J., & Zhivotovsky, B. (2004) · Oncogene · doi:10.1038/sj.onc.1207532 · Cited by 701 · see citing works

The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update

Siddiqui, W. A., Ahad, A., & Ahsan, H. (2015) · Archives of Toxicology · doi:10.1007/s00204-014-1448-7 · Cited by 689 · see citing works

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

Aqeilan, R. I., Calin, G. A., & Croce, C. M. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.69 · Cited by 650 · see citing works

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

Edlich, F., Banerjee, S., Suzuki, M., Cleland, M. M., Arnoult, D., Wang, C., Neutzner, A., Tjandra, N., & Youle, R. J. (2011) · Cell · doi:10.1016/j.cell.2011.02.034 · Cited by 630 · see citing works

The role of BH3-only proteins in the immune system

Strasser, A. (2005) · Nature reviews. Immunology · doi:10.1038/nri1568 · Cited by 624 · see citing works

Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor

Palmer, A. E., Jin, C., Reed, J. C., & Tsien, R. Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408030101 · Cited by 616 · see citing works

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

Ley, R., Balmanno, K., Hadfield, K., Weston, C. R., & Cook, S. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301010200 · Cited by 609 · see citing works

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737

Moore, V. D. G., Brown, J. R., Certo, M. V., Love, T. M., Novina, C. D., & Letai, A. G. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28281 · Cited by 604 · see citing works

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

Kim, H., Tu, H.-C., Ren, D., Takeuchi, O., Jeffers, J. R., Zambetti, G. P., Hsieh, J. J.-D., & Cheng, E. H.-Y. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.030 · Cited by 600 · see citing works

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiationPreprint

Nijhawan, D., Fang, M., Traer, E. A., Zhong, Q., Gao, W., Du, F., & Wang, X. (2003) · Genes & Development · doi:10.1101/gad.1093903 · Cited by 590 · see citing works

Major apoptotic mechanisms and genes involved in apoptosis

Kiraz, Y., Adan, A., Yandım, M. K., & Baran, Y. (2016) · Tumor Biology · doi:10.1007/s13277-016-5035-9 · Cited by 585 · see citing works

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Heger, M., van Golen, R. F., Broekgaarden, M., & Michel, M. C. (2013) · Pharmacological Reviews · doi:10.1124/pr.110.004044 · Cited by 581 · see citing works

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Marsden, V. S., O'Connor, L., O'Reilly, L. A., Silke, J., Metcalf, D., Ekert, P. G., Huang, D. C. S., Cecconi, F., Kuida, K., Tomaselli, K. J., et al. (2002) · Nature · doi:10.1038/nature01101 · Cited by 578 · see citing works

Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases

Bogoyevitch, M. A., & Kobe, B. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00025-06 · Cited by 572 · see citing works

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

Yu, J., Wang, Z., Kinzler, K. W., Vogelstein, B., & Zhang, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2627984100 · Cited by 565 · see citing works

Apoptosis and autophagy: regulatory connections between two supposedly different processes

Thorburn, A. M. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0154-9 · Cited by 555 · see citing works

The role of Bcl-2 family members in tumorigenesis

Kirkin, V., Joos, S., & Zörnig, M. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.08.009 · Cited by 555 · see citing works

Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy

Almasan, A., & Ashkenazi, A. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00029-7 · Cited by 547 · see citing works

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

Reginato, M. J., Mills, K. R., Paulus, J. K., Lynch, D. K., Sgroi, D. C., Debnath, J., Muthuswamy, S. K., & Brugge, J. S. (2003) · Nature Cell Biology · doi:10.1038/ncb1026 · Cited by 545 · see citing works

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

Niture, S. K., & Jaiswal, A. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.312694 · Cited by 545 · see citing works

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

Peart, M. J., Smyth, G. K., van Laar, R. K., Bowtell, D. D. L., Richon, V. M., Marks, P. A., Holloway, A. J., & Johnstone, R. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500369102 · Cited by 538 · see citing works

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

Breckenridge, D. G., Stojanovic, M., Marcellus, R. C., & Shore, G. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212059 · Cited by 533 · see citing works

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

Strasser, A., Cory, S., & Adams, J. M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.307 · Cited by 530 · see citing works

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

Indran, I. R., Tufo, G., Pervaiz, S., & Brenner, C. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.03.010 · Cited by 524 · see citing works

Protective actions of sex steroid hormones in Alzheimer’s disease

Pike, C. J., Carroll, J. C., Rosario, E. R., & Barron, A. M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.015 · Cited by 524 · see citing works

Indole: A privileged scaffold for the design of anti-cancer agents

Wan, Y., Li, Y., Yan, C., Yan, M., & Tang, Z. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111691 · Cited by 521 · see citing works

Role of AIF in caspase-dependent and caspase-independent cell death

Cregan, S. P., Dawson, V. L., & Slack, R. S. (2004) · Oncogene · doi:10.1038/sj.onc.1207517 · Cited by 520 · see citing works

Chemotherapeutic Approaches for Targeting Cell Death Pathways

Ricci, M., & Zong, W. (2006) · The Oncologist · doi:10.1634/theoncologist.11-4-342 · Cited by 512 · see citing works

Apoptosis: a mechanism of acute and chronic liver injury

Guicciardi, M. E., & Gores, G. J. (2005) · Gut · doi:10.1136/gut.2004.053850 · Cited by 509 · see citing works

BH3 Profiling Identifies Three Distinct Classes of Apoptotic Blocks to Predict Response to ABT-737 and Conventional Chemotherapeutic Agents

Deng, J., Carlson, N. E., Takeyama, K., Cin, P. D., Shipp, M. A., & Letai, A. G. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.07.001 · Cited by 509 · see citing works

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease

Paradies, G. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14205 · Cited by 508 · see citing works

Tumor Necrosis Factor

Varfolomeev, E. E., & Ashkenazi, A. (2004) · Cell · doi:10.1016/s0092-8674(04)00166-7 · Cited by 498 · see citing works

Bim is a suppressor of Myc-induced mouse B cell leukemia

Egle, A., Harris, A. W., Bouillet, P., & Cory, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401471101 · Cited by 482 · see citing works

Ca2+ transfer from the ER to mitochondria: When, how and why

Rizzuto, R., Marchi, S., Bonora, M., Aguiari, P., Bononi, A., Stefani, D. D., Giorgi, C., Leo, S., Rimessi, A., Siviero, R., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.03.015 · Cited by 479 · see citing works

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

Luciano, F., Jacquel, A., Colosetti, P., Herrant, M., Cagnol, S., Pages, G., & Auberger, P. (2003) · Oncogene · doi:10.1038/sj.onc.1206792 · Cited by 477 · see citing works

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

Cheng, G., Tse, J. M., Jain, R. K., & Munn, L. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004632 · Cited by 474 · see citing works

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

Pérez‐Galán, P., Roué, G., Villamor, N., Montserrat, E., Campo, E., & Colomer, D. (2005) · Blood · doi:10.1182/blood-2005-05-2091 · Cited by 460 · see citing works

Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy

Maddika, S., Ande, S. R., Panigrahi, S., Paranjothy, T., Węglarczyk, K., Zuse, A., ESHRAGHI, M., Manda, K., Wiecheć, E., & Łoś, M. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.01.003 · Cited by 460 · see citing works

When ER stress reaches a dead end

Urra, H., Dufey, E., Lisbona, F., Rojas‐Rivera, D., & Hetz, C. A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.07.024 · Cited by 458 · see citing works

Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease

Dong, Y., Chen, H., Gao, J., Liu, Y., Li, J., & Wang, J. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.09.001 · Cited by 442 · see citing works

Oncogene addiction: setting the stage for molecularly targeted cancer therapyPreprint

Sharma, S. V., & Settleman, J. E. (2007) · Genes & Development · doi:10.1101/gad.1609907 · Cited by 442 · see citing works

Clinging to life: cell to matrix adhesion and cell survival

Reddig, P. J., & Juliano, R. L. (2005) · Cancer and Metastasis Reviews · doi:10.1007/s10555-005-5134-3 · Cited by 435 · see citing works

The 14-3-3 cancer connection

Hermeking, H. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1230 · Cited by 434 · see citing works

Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy

Sreedhar, A. S., & Csermely, P. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.11.004 · Cited by 418 · see citing works

Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization

Maier, P., Hartmann, L., Wenz, F. K., & Herskind, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010102 · Cited by 417 · see citing works

Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature

Griffin, M. O., Fricovsky, E. S., Ceballos, G. M., & Villarreal, F. J. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00047.2010 · Cited by 414 · see citing works

The roles of microRNA in cancer and apoptosis

Lynam‐Lennon, N., Maher, S. G., & Reynolds, J. V. (2008) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2008.00061.x · Cited by 408 · see citing works

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

Perciavalle, R. M., Stewart, D. P., Koss, B. S., Lynch, J., Milasta, S., Bathina, M., Temirov, J. P., Harwig, M. C., Pelletier, S. W., Schuetz, J. D., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2488 · Cited by 407 · see citing works

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate

Chen, R., Valencia, I., Zhong, F., McColl, K. S., Roderick, H. L., Bootman, M. D., Berridge, M. J., Conway, S. J., Holmes, A. B., Mignery, G. A., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309146 · Cited by 403 · see citing works

Cytometric assessment of mitochondria using fluorescent probes

Cottet‐Rousselle, C., Ronot, X., Leverve, X. M., & Mayol, J. (2011) · Cytometry Part A · doi:10.1002/cyto.a.21061 · Cited by 402 · see citing works

Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis

Dohi, T., Beltrami, E., Wall, N. R., Plescia, J., & Altieri, D. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22222 · Cited by 401 · see citing works

An IAP-IAP Complex Inhibits Apoptosis

Dohi, T., Okada, K., Xia, F., Wilford, C. E., Samuel, T., Welsh, K., Marusawa, H., Zou, H., Armstrong, R., Matsuzawa, S.-I., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400236200 · Cited by 400 · see citing works

The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction

Mor, A., Abramson, S. B., & Pillinger, M. H. (2005) · Clinical Immunology · doi:10.1016/j.clim.2004.12.009 · Cited by 399 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

From primordial germ cell to primordial follicle: mammalian female germ cell development

Pepling, M. E. (2006) · genesis · doi:10.1002/dvg.20258 · Cited by 392 · see citing works

Calcium Channels and Pumps in Cancer: Changes and Consequences

Monteith, G. R., Davis, F. M., & Roberts‐Thomson, S. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.343061 · Cited by 387 · see citing works

Hepatitis C virus NS5A: tales of a promiscuous protein

Macdonald, A., & Harris, M. (2004) · Journal of General Virology · doi:10.1099/vir.0.80204-0 · Cited by 387 · see citing works

Apoptosis and Necrosis in the Liver

Guicciardi, M. E., Malhi, H., Mott, J. L., & Gores, G. J. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120020 · Cited by 387 · see citing works

Life or death: Neuroprotective and anticancer effects of quercetin

Dajas, F. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.07.005 · Cited by 379 · see citing works

Intracellular signaling mechanisms in photodynamic therapy

Almeida, R. D., Manadas, B. J., Carvalho, A. P., & Duarte, C. B. (2004) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2004.05.003 · Cited by 379 · see citing works

Neuronal cell death in neonatal hypoxia‐ischemia

Northington, F. J., Chavez‐Valdez, R., & Martin, L. J. (2011) · Annals of Neurology · doi:10.1002/ana.22419 · Cited by 378 · see citing works

Gallic acid: Molecular rival of cancer

Verma, S., Singh, A., & Mishra, A. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.02.011 · Cited by 371 · see citing works

The cholangiopathies: Disorders of biliary epithelia

Lazaridis, K. N., Strazzabosco, M., & LaRusso, N. F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.006 · Cited by 369 · see citing works

The Bcl-2 family: roles in cell survival and oncogenesis

Cory, S., Huang, D. C. S., & Adams, J. M. (2003) · Oncogene · doi:10.1038/sj.onc.1207102 · Cited by 1,455 · see citing works

Regulation of apoptosis by Bcl‐2 family proteins

Burlacu, A. (2003) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2003.tb00225.x · Cited by 469 · see citing works

Bcl-2 Gene Family

Felicella, M. M., & Jen, K. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-374984-0.00143-1 · Cited by 2 · see citing works

The BCL-2 protein family: opposing activities that mediate cell death

Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,704 · see citing works

Role of Bcl-2 family proteins and caspases in the regulation of apoptosis

Ola, M. S., Nawaz, M. I., & Ahsan, H. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0709-x · Cited by 916 · see citing works