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HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+T cells
Open accessAbstract
We recently reported that HLA-G1-transfected antigen-presenting cells (HLA-G1+APCs) were capable of inhibiting alloproliferative responses. The aim of the present work was to further study the function and the mechanisms of action of HLA-G1+APCs. We show here that HLA-G1+APCs are immunoinhibitory cells that (i) inhibit the proliferation of CD4+T cells, (ii) shed HLA-G1 molecules that might provide extra, non-antigen-specific, inhibitory or proapoptotic signals, (iii) induce CD4+T cell anergy, or at least long-term unresponsiveness, and (iv) cause the differentiation of CD4+T cells into suppressive cells. Thus, HLA-G+APCs might (i) be involved in the direct suppression of immune responses and (ii) contribute to long-term efficient immune escape or tolerance.
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Citations
Cited by
Tumor-Associated Macrophages: From Mechanisms to Therapy
Noy, R., & Pollard, J. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.010 · Cited by 4,089
“In addition, HLA-G-transfected APCs can inhibit CD4+ T cell activation and induce immunosuppressive differentiation in vitro (LeMaoult et al., 2004).”
BackgroundFetomaternal immune cross-talk and its consequences for maternal and offspring's health
Arck, P. C., & Hecher, K. (2013) · Nature Medicine · doi:10.1038/nm.3160 · Cited by 600
Beyond the increasing complexity of the immunomodulatory HLA-G molecule
Carosella, E. D., Favier, B., Rouas-Freiss, N., Moreau, P., & LeMaoult, J. (2008) · Blood · doi:10.1182/blood-2007-12-127662 · Cited by 348
Self-citationLee, D., Ahn, J., & Choi, J. (2025) · BMC Bioinformatics · doi:10.1186/s12859-025-06125-0 · Cited by 4
Metadata
- Authors
- LeMaoult, J., Krawice-Radanne, I., Dausset, J., & Carosella, E. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-04-21
- Volume
- 101
- Issue
- 18
- Pages
- 7064-7069
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2142982199
- Cited by
- 314
- References
- 0
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+T cells. https://app.cochat.ai/papers/10.1073/pnas.0401922101
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- LeMaoult, J., Krawice-Radanne, I., Dausset, J., & Carosella, E. D. (2004). HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+T cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0401922101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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