Beyond the increasing complexity of the immunomodulatory HLA-G molecule
Abstract
Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC) class I molecule that functions as an immunomodulatory molecule capable of protecting fetal tissues from the maternal immune system. The relevance of HLA-G in other contexts was investigated soon afterward. Numerous studies have sought (and some have shown) the relevance of HLA-G in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies. One of the main goals of the current research on HLA-G is now to use it in the clinic, either for diagnosis or as a therapeutic tool/target. For this, precise knowledge on the nature and functions of HLA-G is critical. We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant.
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HLA-G interacts with natural killer cells as part of the innate immune system and is primarily expressed in placental tissues as part of immune tolerance during pregnancy.
“HLA-G interacts with natural killer cells as part of the innate immune system and is primarily expressed in placental tissues as part of immune tolerance during pregnancy (Carosella et al, 2008).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Carosella et al, 2008
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A novel sandwich ELISA for α1 domain based detection of soluble HLA-G heavy chains
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Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation
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Self-citationImmunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
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Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells
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The role of classical and non-classical HLA class I antigens in human tumors
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In silico analysis of microRNAS targeting the HLA-G 3′ untranslated region alleles and haplotypes
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Self-citationMolecular Pathways: Human Leukocyte Antigen G (HLA-G)
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HLA-G Molecules in Autoimmune Diseases and Infections
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Mesenchymal stem cells and cardiac repair
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microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer
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The Dual Role of HLA-G in Cancer
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HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction
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Non‐classical transcriptional regulation of HLA‐G: an update
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The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells
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Immunomodulatory Properties of HLA-G in Infectious Diseases
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HLA-G–dependent suppressor cells: Diverse by nature, function, and significance
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Self-citationThe tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells
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Self-citationMultimeric structures of HLA-G isoforms function through differential binding to LILRB receptors
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Human leukocyte antigen-G in the male reproductive system and in seminal plasma
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Expression of HLA-G by mast cells is associated with hepatitis C virus-induced liver fibrosis
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Self-citationEmerging topics and new perspectives on HLA-G
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New insights into HLA ‐G mediated tolerance
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Immunohistochemical Study of HLA-G Expression in Lung Transplant Recipients
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Self-citationHLA-G Expression in Human Embryonic Stem Cells and Preimplantation Embryos
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Self-citationHLA‐G: Function, polymorphisms and pathology
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Specific central nervous system recruitment of HLA‐G+ regulatory T cells in multiple sclerosis
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The Potential of HLA-G-Bearing Extracellular Vesicles as a Future Element in HLA-G Immune Biology
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Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells
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The tolerogenic molecule HLA-G
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Self-citationRREB-1 Is a Transcriptional Repressor of HLA-G
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The role of HLA-G in immunity and hematopoiesis
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Self-citationComparison of Mesenchymal Stem Cells Isolated From Pulp and Periodontal Ligament
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Endosomal Signaling and a Novel Pathway Defined by the Natural Killer Receptor KIR2DL4 (CD158d)
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Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells
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HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus
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Self-citationWhat the HLA-I!—Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes
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HLA-G Expression Is an Independent Predictor for Improved Survival in High Grade Ovarian Carcinomas
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Self-citationFirst immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G
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Self-citationSilva, T. G., Crispim, J. C. O., Miranda, F. A., Hassumi, M. K., de Mello, J. M. Y., Simões, R. T., Souto, F. J. D., Soares, E. G., Donadi, E. A., & Soares, C. P. (2011) · PubMed · doi:10.14670/hh-26.1487 · Cited by 53 · see citing works
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Self-citation
- Authors
- Carosella, E. D., Favier, B., Rouas-Freiss, N., Moreau, P., & LeMaoult, J.
- Affiliations
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- CEA, I2BM, Service de Recherches en Hemato-Immunologie, Paris, France
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-05-15
- Volume
- 111
- Issue
- 10
- Pages
- 4862-4870
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1979253523
- Cited by
- 348
- References
- 94
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 16 · 2021: 12 · 2020: 17 · 2019: 17 · 2018: 13 · 2017: 10 · 2016: 25 · 2015: 31 · 2014: 27 · 2013: 21 · 2012: 32
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- HLA-G, immunomodulation, non-classical MHC class I, maternal-fetal immune tolerance, transplantation, autoimmunity, tumor immunology, hematologic malignancies
- MeSH terms
- Female, HLA Antigens, Humans, Immune System, Immunologic Factors, Killer Cells, Natural, Male, Pregnancy, Receptors, Immunologic, Histocompatibility Antigens Class I, Hematologic Neoplasms, HLA-G Antigens
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