Cited by 348Reproductive System and PregnancyImmune Cell Function and InteractionImmunotherapy and Immune Responses

Beyond the increasing complexity of the immunomodulatory HLA-G molecule

Carosella, Edgardo D., Favier, Benoit, Rouas-Freiss, Nathalie, Moreau, Philippe, LeMaoult, Joel·2008·Blood

Abstract

Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC) class I molecule that functions as an immunomodulatory molecule capable of protecting fetal tissues from the maternal immune system. The relevance of HLA-G in other contexts was investigated soon afterward. Numerous studies have sought (and some have shown) the relevance of HLA-G in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies. One of the main goals of the current research on HLA-G is now to use it in the clinic, either for diagnosis or as a therapeutic tool/target. For this, precise knowledge on the nature and functions of HLA-G is critical. We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant.

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Crossref · 10.1182/blood-2007-12-127662

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94 of 94 references verified0 citation errors · 0 not checkable

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  • HLA-G interacts with natural killer cells as part of the innate immune system and is primarily expressed in placental tissues as part of immune tolerance during pregnancy.

    “HLA-G interacts with natural killer cells as part of the innate immune system and is primarily expressed in placental tissues as part of immune tolerance during pregnancy (Carosella et al, 2008).”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Carosella et al, 2008

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Authors
Carosella, E. D., Favier, B., Rouas-Freiss, N., Moreau, P., & LeMaoult, J.
Affiliations
  • Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
  • CEA, I2BM, Service de Recherches en Hemato-Immunologie, Paris, France
Venue
Blood
Published
2008-05-15
Volume
111
Issue
10
Pages
4862-4870
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W1979253523
Cited by
348
References
94
Citations by year
2026: 3 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 16 · 2021: 12 · 2020: 17 · 2019: 17 · 2018: 13 · 2017: 10 · 2016: 25 · 2015: 31 · 2014: 27 · 2013: 21 · 2012: 32
FWCI
2.16
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
HLA-G, immunomodulation, non-classical MHC class I, maternal-fetal immune tolerance, transplantation, autoimmunity, tumor immunology, hematologic malignancies
MeSH terms
Female, HLA Antigens, Humans, Immune System, Immunologic Factors, Killer Cells, Natural, Male, Pregnancy, Receptors, Immunologic, Histocompatibility Antigens Class I, Hematologic Neoplasms, HLA-G Antigens

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