The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Fluid-dynamical basis of the embryonic development of left-right asymmetry in vertebrates
Open accessAbstract
Experimental work in developmental biology has recently shown in mice that fluid flow driven by rotating cilia in the node, a structure present in the early stages of growth of vertebrate embryos, is responsible for determining the normal development of the left-right axis, with the heart on the left of the body, the liver on the right, and so on. The role of physics, in particular, of fluid dynamics, in the process is one of the important questions that remain to be answered. We show with an analysis of the fluid dynamics of the nodal flow in the developing embryo that the leftward flow that has been experimentally observed may be produced by the monocilia driving it being tilted toward the posterior. We propose a model for morphogen transport and mixing in the nodal flow and discuss how the development of left-right asymmetry might be initiated.
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Citations
Cites
The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
Purcell, E. M. (1977) · American Journal of Physics · doi:10.1119/1.10903 · Cited by 4,360
Cited by
Physics of microswimmers—single particle motion and collective behavior: a review
Elgeti, J., Winkler, R. G., & Gompper, G. (2015) · Reports on Progress in Physics · doi:10.1088/0034-4885/78/5/056601 · Cited by 1,514
Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis Determination
Okada, Y., Takeda, S., Tanaka, Y., Belmonte, J.-C. I., & Hirokawa, N. (2005) · Cell · doi:10.1016/j.cell.2005.04.008 · Cited by 489
Chlamydomonas Swims with Two “Gears” in a Eukaryotic Version of Run-and-Tumble Locomotion
Polin, M., Tuval, I., Drescher, K., Gollub, J. P., & Goldstein, R. E. (2009) · Science · doi:10.1126/science.1172667 · Cited by 462
Self-citationDe Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia
Nonaka, S., Yoshiba, S., Watanabe, D., Ikeuchi, S., Goto, T., Marshall, W. F., & Hamada, H. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030268 · Cited by 320
A driving force for change: interstitial flow as a morphoregulator
Rutkowski, J. M., & Swartz, M. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.11.007 · Cited by 302
Metadata
- Authors
- Cartwright, J. H. E., Piro, O., & Tuval, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-04-26
- Volume
- 101
- Issue
- 19
- Pages
- 7234-7239
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003103160
- Cited by
- 190
- References
- 2
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Cartwright, J. H. E., Piro, O., & Tuval, I. (2004). Fluid-dynamical basis of the embryonic development of left-right asymmetry in vertebrates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0402001101
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