The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia
Open accessAbstract
In the developing mouse embryo, leftward fluid flow on the ventral side of the node determines left-right (L-R) asymmetry. However, the mechanism by which the rotational movement of node cilia can generate a unidirectional flow remains hypothetical. Here we have addressed this question by motion and morphological analyses of the node cilia and by fluid dynamic model experiments. We found that the cilia stand, not perpendicular to the node surface, but tilted posteriorly. We further confirmed that such posterior tilt can produce leftward flow in model experiments. These results strongly suggest that L-R asymmetry is not the descendant of pre-existing L-R asymmetry within each cell but is generated de novo by combining three sources of spatial information: antero-posterior and dorso-ventral axes, and the chirality of ciliary movement.
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Self-citationTwo Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse
McGrath, J., Somlo, S., Makova, S., Tian, X., & Brueckner, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00511-7 · Cited by 797
Determination of left–right patterning of the mouse embryo by artificial nodal flow
Nonaka, S., Shiratori, H., Saijoh, Y., & Hamada, H. (2002) · Nature · doi:10.1038/nature00849 · Cited by 682
Self-citationEssner, J. J., Amack, J. D., Nyholm, M. K., Harris, E. B., & Yost, H. J. (2005) · Development · doi:10.1242/dev.01663 · Cited by 618
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Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice
Supp, D. M., Witte, D. P., Potter, S. S., & Brueckner, M. (1997) · Nature · doi:10.1038/40140 · Cited by 554
Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis Determination
Okada, Y., Takeda, S., Tanaka, Y., Belmonte, J.-C. I., & Hirokawa, N. (2005) · Cell · doi:10.1016/j.cell.2005.04.008 · Cited by 489
Establishment of vertebrate left–right asymmetry
Hamada, H., Meno, C., Watanabe, D., & Saijoh, Y. (2002) · Nature Reviews Genetics · doi:10.1038/nrg732 · Cited by 489
Self-citationAbnormal Nodal Flow Precedes Situs Inversus in iv and inv mice
Okada, Y., Nonaka, S., Tanaka, Y., Saijoh, Y., Hamada, H., & Hirokawa, N. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80197-5 · Cited by 426
Self-citationThe development of handedness in left/right asymmetry
Brown, N. A., & Wolpert, L. (1990) · Development · doi:10.1242/dev.109.1.1 · Cited by 410
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Self-citationCilia: Tuning in to the Cell's Antenna
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Self-citation
Metadata
- Authors
- Nonaka, S., Yoshiba, S., Watanabe, D., Ikeuchi, S., Goto, T., Marshall, W. F., & Hamada, H.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2005-07-26
- Volume
- 3
- Issue
- 8
- Pages
- e268
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2122596916
- Cited by
- 320
- References
- 20
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nonaka, S., Yoshiba, S., Watanabe, D., Ikeuchi, S., Goto, T., Marshall, W. F., & Hamada, H. (2005). De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia. PLoS Biology. https://doi.org/10.1371/journal.pbio.0030268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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