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Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3
Open accessAbstract
The CD3εγ heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3εγ heterodimer is described to 2.1-Å resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells. The mode of CD3εγ dimerization provides a general structural basis for CD3 assembly and maps candidate T cell antigen receptor docking sites, including a duplicated linear region rich in acidic residues that is unique to human CD3ε. OKT3 binds to an atypically small area of CD3ε and has a low affinity for the isolated CD3εγ heterodimer. The structure of the OKT3/CD3εγ complex has implications for T cell signaling and therapeutic design.
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Cited by
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Targeting a neoantigen derived from a common TP53 mutation
Hsiue, E. H.-C., Wright, K. M., Douglass, J., Hwang, M. S., Mog, B. J., Pearlman, A. H., Paul, S., DiNapoli, S. R., Konig, M. F., Wang, Q., et al. (2021) · Science · doi:10.1126/science.abc8697 · Cited by 367
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Yewdell, J. W. (2006) · Immunity · doi:10.1016/j.immuni.2006.09.005 · Cited by 364
Structural basis of assembly of the human T cell receptor–CD3 complex
Dong, D., Zheng, L., Lin, J., Zhang, B., Zhu, Y., Li, N., Xie, S., Wang, Y., Gao, N., & Huang, Z. (2019) · Nature · doi:10.1038/s41586-019-1537-0 · Cited by 346
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Metadata
- Authors
- Kjer-Nielsen, L., Dunstone, M. A., Kostenko, L., Ely, L. K., Beddoe, T., Mifsud, N. A., Purcell, A. W., Brooks, A. G., McCluskey, J., & Rossjohn, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-05-10
- Volume
- 101
- Issue
- 20
- Pages
- 7675-7680
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2012203161
- Cited by
- 181
- References
- 0
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Kjer-Nielsen, L., Dunstone, M. A., Kostenko, L., Ely, L. K., Beddoe, T., Mifsud, N. A., Purcell, A. W., Brooks, A. G., McCluskey, J., & Rossjohn, J. (2004). Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0402295101
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