The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Inhibition of influenza virus production in virus-infected mice by RNA interference
Open accessAbstract
Influenza A virus infection is a major source of morbidity and mortality worldwide. Because the effectiveness of existing vaccines and antiviral drugs is limited, development of new treatment modalities is needed. Here, we show that short interfering RNAs (siRNAs) specific for conserved regions of influenza virus genes can prevent and treat influenza virus infection in mice. Virus production in lungs of infected mice is reduced by siRNAs given either before or after initiating virus infection, by using slow i.v. administration of small volumes containing siRNAs in complexes with a polycation carrier. Similar effects also are observed when mice are given DNA vectors i.v. or intranasally, from which siRNA precursors can be transcribed. Development of delivery systems that may be compatible with human use demonstrates the potential utility of siRNAs for prophylaxis and therapy of influenza virus infections in humans.
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Benefits of influenza vaccination for low-, intermediate-, and high-risk senior citizens.
Nichol, K. L., Wuorenma, J., & von Sternberg, T. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.16.1769 · Cited by 484
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Jackson, A. L., & Linsley, P. S. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3010 · Cited by 1,083
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
DuPage, M., Dooley, A. L., & Jacks, T. (2009) · Nature Protocols · doi:10.1038/nprot.2009.95 · Cited by 894
Progress towards in Vivo Use of siRNAs
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De Clercq, E. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2175 · Cited by 668
Metadata
- Authors
- Ge, Q., Filip, L., Bai, A., Nguyen, T., Eisen, H. N., & Chen, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-06
- Volume
- 101
- Issue
- 23
- Pages
- 8676-8681
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088650511
- Cited by
- 444
- References
- 2
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Ge, Q., Filip, L., Bai, A., Nguyen, T., Eisen, H. N., & Chen, J. (2004). Inhibition of influenza virus production in virus-infected mice by RNA interference. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0402486101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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