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Cell mechanosensitivity controls the anisotropy of focal adhesions
Open accessAbstract
Cellular adhesions are modulated by cytoskeletal forces or external stresses and adapt to the mechanical properties of the extracellular matrix. We propose that this mechanosensitivity can be driven at least in part by the elastic, cell-contractility-induced deformations of protein molecules that form the adhesion. The model accounts for observations of anisotropic growth and shrinkage of focal adhesions in the direction of the force and predicts that focal adhesions only grow within a range of force that is determined by the composition and matrix properties. This prediction is consistent with the observations of a force threshold for the appearance of elongated focal adhesions and the disruption of adhesions into fibrils on a mobile extracellular matrix. The growth dynamics is calculated and the predicted sliding of focal adhesions is consistent with several experiments.
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Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869
Cell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289
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Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941
The Mechanics and Statistics of Active Matter
Ramaswamy, S. (2010) · Annual Review of Condensed Matter Physics · doi:10.1146/annurev-conmatphys-070909-104101 · Cited by 2,038
Plotnikov, S. V., Pasapera, A. M., Sabass, B., & Waterman, C. M. (2012) · Cell · doi:10.1016/j.cell.2012.11.034 · Cited by 866
The myofibroblast: Paradigm for a mechanically active cell
Hinz, B. (2010) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.020 · Cited by 698
Metadata
- Authors
- Nicolas, A., Geiger, B., & Safran, S. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-08-16
- Volume
- 101
- Issue
- 34
- Pages
- 12520-12525
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2123029770
- Cited by
- 229
- References
- 2
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Nicolas, A., Geiger, B., & Safran, S. A. (2004). Cell mechanosensitivity controls the anisotropy of focal adhesions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0403539101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
