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Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells
Open accessAbstract
A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily considered to be self-reactive. By employing CD1d-binding and T cell assays, the following structural parameters for presentation by CD1d were defined for a number of mycobacterial and mammalian lipids: two acyl chains facilitated binding, and a polar head group was essential for T cell recognition. Of the mycobacterial lipids tested, only a phosphatidylinositol mannoside (PIM) fulfilled the requirements for CD1d binding and NKT cell stimulation. This PIM activated human and murine NKT cells via CD1d, thereby triggering antigen-specific IFN-γ production and cell-mediated cytotoxicity, and PIM-loaded CD1d tetramers identified a subpopulation of murine and human NKT cells. This phospholipid, therefore, represents a mycobacterial antigen recognized by T cells in the context of CD1d.
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Citations
Cited by
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Mattner, J., DeBord, K. L., Ismail, N., Goff, R. D., Cantu, C., Zhou, D., Saint-Mezard, P., Wang, V., Gao, Y., Yin, N., et al. (2005) · Nature · doi:10.1038/nature03408 · Cited by 1,121
Lysosomal Glycosphingolipid Recognition by NKT Cells
Zhou, D., Mattner, J., Cantu, C., Schrantz, N., Yin, N., Gao, Y., Sagiv, Y., Hudspeth, K., Wu, Y.-P., Yamashita, T., et al. (2004) · Science · doi:10.1126/science.1103440 · Cited by 956
Immunological processes in malaria pathogenesis
Schofield, L., & Grau, G. E. (2005) · Nature Reviews Immunology · doi:10.1038/nri1686 · Cited by 688
Ito Cells Are Liver-Resident Antigen-Presenting Cells for Activating T Cell Responses
Winau, F., Hegasy, G., Weiskirchen, R., Weber, S., Cassan, C., Sieling, P. A., Modlin, R. L., Liblau, R. S., Gressner, A. M., & Kaufmann, S. H. E. (2007) · Immunity · doi:10.1016/j.immuni.2006.11.011 · Cited by 410
Self-citationCell wall glycosphingolipids ofSphingomonas paucimobilisare CD1d-specific ligands for NKT cells
Sriram, V., Du, W., Gervay-Hague, J., & Brutkiewicz, R. R. (2005) · European Journal of Immunology · doi:10.1002/eji.200526157 · Cited by 309
Metadata
- Authors
- Fischer, K., Scotet, E., Niemeyer, M., Koebernick, H., Zerrahn, J., Maillet, S., Hurwitz, R., Kursar, M., Bonneville, M., Kaufmann, S. H. E., & Schaible, U. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-07-08
- Volume
- 101
- Issue
- 29
- Pages
- 10685-10690
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1976710853
- Cited by
- 378
- References
- 0
- FWCI
- 15.46
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. https://app.cochat.ai/papers/10.1073/pnas.0403787101
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- Fischer, K., Scotet, E., Niemeyer, M., Koebernick, H., Zerrahn, J., Maillet, S., Hurwitz, R., Kursar, M., Bonneville, M., Kaufmann, S. H. E., & Schaible, U. E. (2004). Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0403787101
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