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Cited by 803

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Social supports and serotonin transporter gene moderate depression in maltreated children

Open access
Kaufman, Joan, Yang, Bao-Zhu, Douglas-Palumberi, Heather, Houshyar, Shadi, Lipschitz, Deborah, Krystal, John H., Gelernter, Joel·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0404376101
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Abstract

In this study, measures of the quality and availability of social supports were found to moderate risk for depression associated with a history of maltreatment and the presence of the short (s) allele of the serotonin transporter gene promoter polymorphism (5-HTTLPR). The present investigation ( i ) replicates research in adults showing that 5-HTTLPR variation moderates the development of depression after stress, ( ii ) extends the finding to children, and ( iii ) demonstrates the ability of social supports to further moderate risk for depression. Maltreated children with the s/s genotype and no positive supports had the highest depression ratings, scores that were twice as high as the non-maltreated comparison children with the same genotype. However, the presence of positive supports reduced risk associated with maltreatment and the s/s genotype, such that maltreated children with this profile had only minimal increases in their depression scores. These findings are consistent with emerging preclinical and clinical data suggesting that the negative sequelae associated with early stress are not inevitable. Risk for negative outcomes may be modified by both genetic and environmental factors, with the quality and availability of social supports among the most important environmental factors in promoting resiliency in maltreated children, even in the presence of a genotype expected to confer vulnerability for psychiatric disorder.

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Research works printed but not linked: 8

  1. Schildkraut, J., Green, A. & Mooney, J. (1989) in Comprehensive Textbook of Psychiatry, eds. Kaplan, H. & Sadock, B. (Williams & Wilkins, Baltimore), Vol. 1, pp. 868–879.
  2. Bennett, A. J., Lesch, K. P., Heils, A., Long, J. C., Lorenz, J. G., Shoaf, S. E., Champoux, M., Suomi, S. J., Linnoila, M. V., Higley, J. D., et al. (1998) Am. J. Psychiatry 155, 118–122.
  3. Pine D. S. McClure E. B. Hoberman A. J. Schweder A. Leibenluft E. Ernst M. Charney D. S. & Kaufman J. Am. J. Psychiatry in press.
  4. Barrera, M. (1980) Connections 3, 8–13.
  5. Barth, R. P. (1994) Child Welfare 73, 625–638.7924567
  6. 10.2307/1602597 · doi:10.2307/1602597
  7. Webster, D., Barth, R. P. & Needell, B. (2000) Child Welfare 79, 614–632.11021350
  8. DeSena A. D. Murphy R. A. Douglas-Palumberi H. Blau G. Kelly B. Horwitz S. M. & Kaufman J. Child Abuse Neglect in press.

Cited by

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Metadata

Authors
Kaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J. H., & Gelernter, J.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2004-11-24
Volume
101
Issue
49
Pages
17316-17321
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0404376101
OpenAlex
W2105874139
Cited by
803
References
41
FWCI
64.48
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Social supports and serotonin transporter gene moderate depression in maltreated children. https://app.cochat.ai/papers/10.1073/pnas.0404376101
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Kaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J. H., & Gelernter, J. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0404376101

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