The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing
Open accessAbstract
Staphylococcus aureus is the leading cause of wound and hospital-acquired infections worldwide. The emergence of S. aureus strains with resistance to multiple antibiotics requires the identification of bacterial virulence genes and the development of novel therapeutic strategies. Herein, bursa aurealis , a mariner-based transposon, was used for random mutagenesis and for the isolation of 10,325 S. aureus variants with defined insertion sites. By screening for loss-of-function mutants in a Caenorhabditis elegans killing assay, 71 S. aureus virulence genes were identified. Some of these genes are also required for S. aureus abscess formation in a murine infection model.
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Cites
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834
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Infection with Vancomycin-Resistant Staphylococcus aureus Containing the vanA Resistance Gene
Chang, S., Sievert, D. M., Hageman, J. C., Boulton, M. L., Tenover, F. C., Downes, F. P., Shah, S., Rudrik, J. T., Pupp, G. R., Brown, W. J., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025025 · Cited by 1,095
Oliveira, D. C., Tomasz, A., & de Lencastre, H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00227-x · Cited by 494
LYSOSTAPHIN: A NEW BACTERIOLYTIC AGENT FOR THE STAPHYLOCOCCUS
Schindler, C. A., & Schuhardt, V. T. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.3.414 · Cited by 482
Cited by
Insights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils
Voyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563
Targeting virulence: can we make evolution-proof drugs?
Allen, R. C., Popat, R., Diggle, S. P., & Brown, S. P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3232 · Cited by 532
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues
Cheng, A. G., Kim, H. K., Burts, M. L., Krausz, T., Schneewind, O., & Missiakas, D. M. (2009) · The FASEB Journal · doi:10.1096/fj.09-135467 · Cited by 437
Self-citationRetractedQian, W., Jia, Y., Ren, S.-X., He, Y.-Q., Feng, J.-X., Lu, L.-F., Sun, Q., Ying, G., Tang, D.-J., Tang, H., et al. (2005) · Genome Research · doi:10.1101/gr.3378705 · Cited by 417
Surface Proteins and Exotoxins Are Required for the Pathogenesis of Staphylococcus aureus Pneumonia
Wardenburg, J. B., Patel, R. J., & Schneewind, O. (2007) · Infection and Immunity · doi:10.1128/iai.01313-06 · Cited by 348
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Metadata
- Authors
- Bae, T., Banger, A. K., Wallace, A., Glass, E. M., Åslund, F., Schneewind, O., & Missiakas, D. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-08-10
- Volume
- 101
- Issue
- 33
- Pages
- 12312-12317
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2001277616
- Cited by
- 315
- References
- 5
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Bae, T., Banger, A. K., Wallace, A., Glass, E. M., Åslund, F., Schneewind, O., & Missiakas, D. M. (2004). Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0404728101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
