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Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles
Open accessAbstract
We find that single- and double-stranded oligonucleotides have different propensities to adsorb on gold nanoparticles in colloidal solution. We use this observation to design a hybridization assay based on color changes associated with gold aggregation. Because the underlying adsorption mechanism is electrostatic, no covalent functionalization of the gold, the probe, or the target DNA is required. Hybridization conditions can be optimized because it is completely separated from the detection step. The assay is complete within 5 min, and <100 femtomoles of target produces color changes observable without instrumentation. Single-base-pair mismatches are easily detected.
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Cited by
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Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
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Metadata
- Authors
- Li, H., & Rothberg, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-09-20
- Volume
- 101
- Issue
- 39
- Pages
- 14036-14039
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2028310736
- Cited by
- 1,342
- References
- 1
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
