The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Aneuploid neurons are functionally active and integrated into brain circuitry
Open accessAbstract
The existence of aneuploid cells within the mammalian brain has suggested the influence of genetic mosaicism on normal neural circuitry. However, aneuploid cells might instead be glia, nonneural, or dying cells, which are irrelevant to direct neuronal signaling. Combining retrograde labeling with FISH for chromosome-specific loci, distantly labeled aneuploid neurons were observed in expected anatomical projection areas. Coincident labeling for immediate early gene expression indicated that these aneuploid neurons were functionally active. These results demonstrate that functioning neurons with aneuploid genomes form genetically mosaic neural circuitries as part of the normal organization of the mammalian brain.
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Cites
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
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Embryonic karyotype of abortuses in relation to the number of previous miscarriages
Ogasawara, M., Aoki, K., Okada, S., & Suzumori, K. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00495-1 · Cited by 604
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Elevated gene expression levels distinguish human from non-human primate brains
Cáceres, M., Lachuer, J., Zapala, M. A., Redmond, J. C., Kudo, L., Geschwind, D. H., Lockhart, D. J., Preuss, T. M., & Barlow, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135499100 · Cited by 491
Cited by
Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., & Cleveland, D. W. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.003 · Cited by 729
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
Thompson, S. L., & Compton, D. A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200905057 · Cited by 494
Single cell sequencing reveals low levels of aneuploidy across mammalian tissues
Knouse, K. A., Wu, J., Whittaker, C. A., & Amon, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415287111 · Cited by 314
Cai, X., Evrony, G. D., Lehmann, H. S., Elhosary, P. C., Mehta, B. K., Poduri, A., & Walsh, C. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.043 · Cited by 318
Holland, A. J., & Cleveland, D. W. (2012) · EMBO reports · doi:10.1038/embor.2012.55 · Cited by 288
Metadata
- Authors
- Kingsbury, M. A., Friedman, B., McConnell, M. J., Rehen, S. K., Yang, A. H., Kaushal, D., & Chun, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-04-18
- Volume
- 102
- Issue
- 17
- Pages
- 6143-6147
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978122064
- Cited by
- 177
- References
- 5
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Kingsbury, M. A., Friedman, B., McConnell, M. J., Rehen, S. K., Yang, A. H., Kaushal, D., & Chun, J. (2005). Aneuploid neurons are functionally active and integrated into brain circuitry. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0408171102
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
