Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor

Weaver, Beth A.A.; Silk, Alain D.; Montagna, Cristina; Verdier-Pinard, Pascal; Cleveland, Don W.

doi:10.1016/j.ccr.2006.12.003

Cited by 729Microtubule and mitosis dynamicsCancer-related Molecular PathwaysDNA Repair Mechanisms

Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor

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Weaver, Beth A.A., Silk, Alain D., Montagna, Cristina, Verdier-Pinard, Pascal, Cleveland, Don W.·2007·Cancer Cell

DOI 10.1016/j.ccr.2006.12.003

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Abstract

An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells. Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has remained untested due to the difficulty of selectively generating aneuploidy. Cells and mice with reduced levels of the mitosis-specific, centromere-linked motor protein CENP-E are now shown to develop aneuploidy and chromosomal instability in vitro and in vivo. An increased rate of aneuploidy does drive an elevated level of spontaneous lymphomas and lung tumors in aged animals. Remarkably, however, in examples of chemically or genetically induced tumor formation, an increased rate of aneuploidy is a more effective inhibitor than initiator of tumorigenesis. These findings reveal a role of aneuploidy and chromosomal instability in preventing tumorigenesis.

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Authors: Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., & Cleveland, D. W.
Affiliations: University of California San Diego (US)
Albert Einstein College of Medicine (US)
Corresponding author: Cleveland, Don W.
ORCID: Weaver, Beth A.A.
Silk, Alain D.
Cleveland, Don W.
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2007-01
Volume: 11
Issue: 1
Pages: 25-36
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/j.ccr.2006.12.003
OpenAlex: W2102922697
Cited by: 729
References: 50
Citations by year: 2026: 8 · 2025: 12 · 2024: 22 · 2023: 27 · 2022: 19 · 2021: 23 · 2020: 34 · 2019: 31 · 2018: 32 · 2017: 43 · 2016: 42 · 2015: 56 · 2014: 37 · 2013: 42 · 2012: 58
FWCI: 18.58
Type: journal article
Language: en
Open access: bronze
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Locations: Cancer Cell (publishedVersion)
PubMed (publishedVersion)
HAL AMU (submittedVersion)
HAL (submittedVersion)
Funders: Philip Morris International
National Institutes of Health (GM29513)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: aneuploidy, tumor suppressor function, oncogenic function, chromosomal instability, CENP-E, centromere, mitosis, spontaneous lymphoma, lung cancer, aging, carcinogenesis
MeSH terms: Age Factors, Aneuploidy, Animals, Cell Transformation, Neoplastic, Cells, Cultured, Chromosomal Proteins, Non-Histone, Embryo, Mammalian, Fibroblasts, Neoplasms, In Situ Hybridization, Fluorescence, Mice

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Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor

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