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Cited by 295

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

A vital role of tubulin-tyrosine-ligase for neuronal organization

Open access
Erck, Christian, Peris, Leticia, Andrieux, Annie, Meissirel, Claire, Gruber, Achim D., Vernet, Muriel, Schweitzer, Annie, Saoudi, Yasmina, Pointu, Hervé, Bosc, Christophe, Salin, Paul A., Job, Didier, Wehland, Juergen·2005·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0409626102
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Abstract

Tubulin is subject to a special cycle of detyrosination/tyrosination in which the C-terminal tyrosine of α-tubulin is cyclically removed by a carboxypeptidase and readded by a tubulin-tyrosine-ligase (TTL). This tyrosination cycle is conserved in evolution, yet its physiological importance is unknown. Here, we find that TTL suppression in mice causes perinatal death. A minor pool of tyrosinated (Tyr-)tubulin persists in TTL null tissues, being present mainly in dividing TTL null cells where it originates from tubulin synthesis, but it is lacking in postmitotic TTL null cells such as neurons, which is apparently deleterious because early death in TTL null mice is, at least in part, accounted for by a disorganization of neuronal networks, including a disruption of the cortico-thalamic loop. Correlatively, cultured TTL null neurons display morphogenetic anomalies including an accelerated and erratic time course of neurite outgrowth and a premature axonal differentiation. These anomalies may involve a mislocalization of CLIP170, which we find lacking in neurite extensions and growth cones of TTL null neurons. Our results demonstrate a vital role of TTL for neuronal organization and suggest a requirement of Tyr-tubulin for proper control of neurite extensions.

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Metadata

Authors
Erck, C., Peris, L., Andrieux, A., Meissirel, C., Gruber, A. D., Vernet, M., Schweitzer, A., Saoudi, Y., Pointu, H., Bosc, C., Salin, P. A., Job, D., & Wehland, J.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2005-05-17
Volume
102
Issue
22
Pages
7853-7858
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0409626102
OpenAlex
W2121787173
Cited by
295
References
40
FWCI
4.08
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: A vital role of tubulin-tyrosine-ligase for neuronal organization. https://app.cochat.ai/papers/10.1073/pnas.0409626102
The paper
Erck, C., Peris, L., Andrieux, A., Meissirel, C., Gruber, A. D., Vernet, M., Schweitzer, A., Saoudi, Y., Pointu, H., Bosc, C., Salin, P. A., Job, D., & Wehland, J. (2005). A vital role of tubulin-tyrosine-ligase for neuronal organization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0409626102

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.