The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
Open accessAbstract
Investigations into the cellular and molecular biology of genes that cause inherited forms of Parkinson's disease, as well as the downstream pathways that they trigger, shed considerable light on our understanding the fundamental determinants of life and death in dopaminergic neurons. Homozygous deletion or missense mutation in DJ-1 results in autosomal recessively inherited Parkinson's disease, suggesting that wild-type DJ-1 has a favorable role in maintaining these neurons. Here, we show that DJ-1 protects against oxidative stress-induced cell death, but that its relatively modest ability to quench reactive oxygen species is insufficient to account for its more robust cytoprotective effect. To elucidate the mechanism of this cell-preserving function, we have screened out the death protein Daxx as a DJ-1-interacting partner. We demonstrate that wild-type DJ-1 sequesters Daxx in the nucleus, prevents it from gaining access to the cytoplasm, from binding to and activating its effector kinase apoptosis signal-regulating kinase 1, and therefore, from triggering the ensuing death pathway. All these steps are impaired by the disease-causing L166P mutant isoform of DJ-1. These findings suggest that the regulated sequestration of Daxx in the nucleus and keeping apoptosis signal-regulating kinase 1 activation in check is a critical mechanism by which DJ-1 exerts its cytoprotective function.
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Cites
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
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Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
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Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
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Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease
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Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
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Oxidative stress in Parkinson's disease
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Cited by
The Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845
Self-citationGenetics of Parkinson's Disease
Klein, C., & Westenberger, A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a008888 · Cited by 1,358
Expanding insights of mitochondrial dysfunction in Parkinson's disease
Abou-Sleiman, P. M., Muqit, M. M. K., & Wood, N. W. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1868 · Cited by 869
Thomas, B., & Beal, M. F. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm159 · Cited by 748
Bae, S. K., Heo, C. H., Choi, D. J., Sen, D., Joe, E.-H., Cho, B. R., & Kim, H. M. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404004v · Cited by 411
Metadata
- Authors
- Junn, E., Taniguchi, H., Jeong, B. S., Zhao, X., Ichijo, H., & Mouradian, M. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-06-27
- Volume
- 102
- Issue
- 27
- Pages
- 9691-9696
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1990847293
- Cited by
- 321
- References
- 37
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Junn, E., Taniguchi, H., Jeong, B. S., Zhao, X., Ichijo, H., & Mouradian, M. M. (2005). Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0409635102
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