Cited by 3,837Genetics, Aging, and Longevity in Model OrganismsParathyroid Disorders and TreatmentsTelomeres, Telomerase, and Senescence

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, Makoto, Matsumura, Yutaka, Aizawa, Hiroki, Kawaguchi, Hiroshi, Suga, Tatsuo, Utsugi, Toshihiro, Ohyama, Yoshio, Kurabayashi, Masahiko +8 more·1997·Nature

Abstract

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

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Crossref · 10.1038/36285

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28 of 28 references verified0 citation errors · 0 not checkable

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  • There was age-dependent expression of genes encoding secreted proteins, including Klotho, which increased with age.

    “There were also age-dependent expression of genes encoding secreted proteins (Figure 3H, S3H, Table S3), including the “anti-aging” gene Klotho (Kuro-o et al., 1997; Zhu et al., 2018), which increased with age (Figure 3H).”

    From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Kuro-o et al., 1997

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Authors
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, T., Nishikawa, S., Nagai, R., & Nabeshima, Y.-I.
Affiliations
  • Gunma University (JP)
  • The University of Tokyo (JP)
  • Institute of Molecular Embryology and Genetics, Kumamoto University (JP)
  • National Center of Neurology and Psychiatry (JP)
Corresponding author
Nabeshima, Yo-ichi
Venue
Nature
Published
1997-11-06
Volume
390
Issue
6655
Pages
45-51
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2114360920
Cited by
3,837
References
28
Citations by year
2026: 117 · 2025: 194 · 2024: 234 · 2023: 195 · 2022: 213 · 2021: 220 · 2020: 239 · 2019: 212 · 2018: 225 · 2017: 178 · 2016: 208 · 2015: 194 · 2014: 167 · 2013: 170 · 2012: 154
FWCI
9.34
Type
journal article
Language
en
Open access
closed
Locations
Nature (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
Klotho gene, aging, lifespan, mouse mutations, infertility, arteriosclerosis, osteoporosis, emphysema, skin atrophy, β-glucosidase, membrane proteins, age-related diseases

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