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Cited by 194

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Adeno-associated virus effectively mediates conditional gene modification in the brain

Open access
Kaspar, Brian K., Vissel, Bryce, Bengoechea, Tasha, Crone, Steven, Randolph-Moore, Lynne, Muller, Rolf, Brandon, Eugene P., Schaffer, David, Verma, Inder M., Lee, Kuo-Fen, Heinemann, Stephen F., Gage, Fred H.·2002·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.042678699
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Abstract

The Cre/ lox P system is increasingly showing promise for investigating genes involved in neural function. Here, we demonstrate that in vivo modification of genes in the mouse brain can be accomplished in a spatial- and temporal-specific manner by targeted delivery of an adeno-associated virus (AAV) encoding a green fluorescent protein/Cre recombinase (GFP/Cre) fusion protein. By using a reporter mouse, in which Cre recombinase activates β-galactosidase expression, we demonstrate long-term recombination of neurons in the hippocampus, striatum, and septum as early as 7 days after stereotaxic injection of virus. Recombined cells were observed for at least 6 months postinjection without evidence of cell loss or neural damage. AAV-mediated delivery of GFP/Cre provides a valuable approach to alter the mouse genome, as AAV delivers genes efficiently to neurons with low toxicity. This approach will greatly facilitate the study of genetic modifications in the mouse brain.

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Metadata

Authors
Kaspar, B. K., Vissel, B., Bengoechea, T., Crone, S., Randolph-Moore, L., Muller, R., Brandon, E. P., Schaffer, D., Verma, I. M., Lee, K.-F., Heinemann, S. F., & Gage, F. H.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2002-02-12
Volume
99
Issue
4
Pages
2320-2325
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.042678699
OpenAlex
W2108672978
Cited by
194
References
5
FWCI
5.84
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Adeno-associated virus effectively mediates conditional gene modification in the brain. https://app.cochat.ai/papers/10.1073/pnas.042678699
The paper
Kaspar, B. K., Vissel, B., Bengoechea, T., Crone, S., Randolph-Moore, L., Muller, R., Brandon, E. P., Schaffer, D., Verma, I. M., Lee, K.-F., Heinemann, S. F., & Gage, F. H. (2002). Adeno-associated virus effectively mediates conditional gene modification in the brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.042678699

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.