The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
Open accessAbstract
Influenza A virus causes widespread infection in the human respiratory tract, but existing vaccines and drug therapy are of limited value. Here we show that short interfering RNAs (siRNAs) specific for conserved regions of the viral genome can potently inhibit influenza virus production in both cell lines and embryonated chicken eggs. The inhibition depends on the presence of a functional antisense strand in the siRNA duplex, suggesting that viral mRNA is the target of RNA interference. However, siRNA specific for nucleocapsid (NP) or a component of the RNA transcriptase (PA) abolished the accumulation of not only the corresponding mRNA but also virion RNA and its complementary RNA. These siRNAs also broadly inhibited the accumulation of other viral, but not cellular, RNAs. The findings reveal that newly synthesized NP and PA proteins are required for influenza virus transcription and replication and provide a basis for the development of siRNAs as prophylaxis and therapy for influenza infection in humans.
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Viruses and interferon: a fight for supremacy
Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419
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Polymeric coatings that inactivate both influenza virus and pathogenic bacteria
Haldar, J., An, D., Álvarez de Cienfuegos, L., Chen, J., & Klibanov, A. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608803103 · Cited by 297
Self-citationBitter-sweet symphony: glycan–lectin interactions in virus biology
Van Breedam, W., Pöhlmann, S., Favoreel, H. W., de Groot, R. J., & Nauwynck, H. J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12052 · Cited by 141
Metadata
- Authors
- Ge, Q., McManus, M. T., Nguyen, T., Shen, C.-H., Sharp, P. A., Eisen, H. N., & Chen, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-02-19
- Volume
- 100
- Issue
- 5
- Pages
- 2718-2723
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2106367530
- Cited by
- 526
- References
- 2
- FWCI
- 32.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Ge, Q., McManus, M. T., Nguyen, T., Shen, C.-H., Sharp, P. A., Eisen, H. N., & Chen, J. (2003). RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0437841100
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