The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing
Open accessAbstract
Homology-dependent RNA silencing occurs in many eukaryotic cells. We reported recently that nodaviral infection triggers an RNA silencing-based antiviral response (RSAR) in Drosophila , which is capable of a rapid virus clearance in the absence of expression of a virus-encoded suppressor. Here, we present further evidence to show that the Drosophila RSAR is mediated by the RNA interference (RNAi) pathway, as the viral suppressor of RSAR inhibits experimental RNAi initiated by exogenous double-stranded RNA and RSAR requires the RNAi machinery. We demonstrate that RNAi also functions as a natural antiviral immunity in mosquito cells. We further show that vaccinia virus and human influenza A, B, and C viruses each encode an essential protein that suppresses RSAR in Drosophila . The vaccinia and influenza viral suppressors, E3L and NS1, are distinct double-stranded RNA-binding proteins and essential for pathogenesis by inhibiting the mammalian IFN-regulated innate antiviral response. We found that the double-stranded RNA-binding domain of NS1, implicated in innate immunity suppression, is both essential and sufficient for RSAR suppression. These findings provide evidence that mammalian virus proteins can inhibit RNA silencing, implicating this mechanism as a nucleic acid-based antiviral immunity in mammalian cells.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
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RNA interference is mediated by 21- and 22-nucleotide RNAs
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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
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The Genome Sequence of the Malaria Mosquito Anopheles gambiae
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Self-citationA microRNA in a Multiple-Turnover RNAi Enzyme Complex
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Cited by
Vigilance, alertness, or sustained attention: physiological basis and measurement
Oken, B. S., Salinsky, M. C., & Elsas, S. M. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.01.017 · Cited by 887
The Polerovirus Silencing Suppressor P0 Targets ARGONAUTE Proteins for Degradation
Baumberger, N., Tsai, C.-H., Lie, M., Havecker, E., & Baulcombe, D. C. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.039 · Cited by 391
The Ebola Virus VP35 Protein Is a Suppressor of RNA Silencing
Haasnoot, J., de Vries, W., Geutjes, E.-J., Prins, M., de Haan, P., & Berkhout, B. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030086 · Cited by 317
Hartmann, G. (2017) · Advances in Immunology · doi:10.1016/bs.ai.2016.11.001 · Cited by 285
Yeung, M. L., Bennasser, Y., Watashi, K., Le, S.-Y., Houzet, L., & Jeang, K.-T. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp707 · Cited by 244
Metadata
- Authors
- Li, W.-X., Li, H., Lu, R., Li, F., Dus, M., Atkinson, P., Brydon, E. W. A., Johnson, K. L., García-Sastre, A., Ball, L. A., Palese, P., & Ding, S.-W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-01-26
- Volume
- 101
- Issue
- 5
- Pages
- 1350-1355
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2139268538
- Cited by
- 438
- References
- 41
- FWCI
- 16.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, W.-X., Li, H., Lu, R., Li, F., Dus, M., Atkinson, P., Brydon, E. W. A., Johnson, K. L., García-Sastre, A., Ball, L. A., Palese, P., & Ding, S.-W. (2004). Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0308308100
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