The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The Arabidopsis SUMO E3 ligase SIZ1 controls phosphate deficiency responses
Open accessAbstract
Plants sense phosphate (Pi) deficiency and initiate signaling that controls adaptive responses necessary for Pi acquisition. Herein, evidence establishes that AtSIZ1 is a plant small ubiquitin-like modifier (SUMO) E3 ligase and is a focal controller of Pi starvation-dependent responses. T-DNA insertional mutated alleles of AtSIZ1 (At5g60410) cause Arabidopsis to exhibit exaggerated prototypical Pi starvation responses, including cessation of primary root growth, extensive lateral root and root hair development, increase in root/shoot mass ratio, and greater anthocyanin accumulation, even though intracellular Pi levels in siz1 plants were similar to wild type. AtSIZ1 has SUMO E3 ligase activity in vitro , and immunoblot analysis revealed that the protein sumoylation profile is impaired in siz1 plants. AtSIZ1-GFP was localized to nuclear foci. Steadystate transcript abundances of Pi starvation-responsive genes AtPT2 , AtPS2 , and AtPS3 were moderate but clearly greater in siz1 seedlings than in wild type, where Pi is sufficient. Pi starvation induced the expression of these genes to the same extent in siz1 and wild-type seedlings. However, two other Pi starvation-responsive genes, AtIPS1 and AtRNS1 , are induced more slowly in siz1 seedlings by Pi limitation. PHR1, a MYB transcriptional activator of AtIPS1 and AtRNS1 , is an AtSIZ1 sumoylation target. These results indicate that AtSIZ1 is a SUMO E3 ligase and that sumoylation is a control mechanism that acts both negatively and positively on different Pi deficiency responses.
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Self-citationJohnson, E. S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074118 · Cited by 1,675
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Self-citationThe role of nutrient availability in regulating root architecture
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Nuclear and unclear functions of SUMO
Seeler, J.-S., & Dejean, A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1200 · Cited by 667
The Polycomb Protein Pc2 Is a SUMO E3
Kagey, M. H., Melhuish, T. A., & Wotton, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00159-4 · Cited by 581
AtHKT1 is a salt tolerance determinant that controls Na + entry into plant roots
Rus, A., Yokoi, S., Sharkhuu, A., Reddy, M., Lee, B.-H., Matsumoto, T. K., Koiwa, H., Zhu, J.-K., Bressan, R. A., & Hasegawa, P. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241501798 · Cited by 504
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MYB transcription factors in Arabidopsis
Dubos, C., Stracke, R., Grotewold, E., Weisshaar, B., Martin, C., & Lepiniec, L. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.06.005 · Cited by 4,865
Regulation of Phosphate Homeostasis by MicroRNA in Arabidopsis
Chiou, T.-J., Aung, K., Lin, S.-I., Wu, C.-C., Chiang, S.-F., & Su, C.-L. (2006) · The Plant Cell · doi:10.1105/tpc.105.038943 · Cited by 873
A miRNA Involved in Phosphate-Starvation Response in Arabidopsis
Fujii, H., Chiou, T.-J., Lin, S.-I., Aung, K., & Zhu, J.-K. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.016 · Cited by 868
Bustos, R., Castrillo, G., Linhares, F., Puga, M. I., Rubio, V., Pérez-Pérez, J., Solano, R., Leyva, A., & Paz-Ares, J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001102 · Cited by 783
Miura, K., Jin, J. B., Lee, J., Yoo, C. Y., Stirm, V., Miura, T., Ashworth, E. N., Bressan, R. A., Yun, D.-J., & Hasegawa, P. M. (2007) · The Plant Cell · doi:10.1105/tpc.106.048397 · Cited by 770
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Metadata
- Authors
- Miura, K., Rus, A., Sharkhuu, A., Yokoi, S., Karthikeyan, A. S., Raghothama, K. G., Baek, D., Koo, Y. D., Jin, J. B., Bressan, R. A., Yun, D.-J., & Hasegawa, P. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-05-13
- Volume
- 102
- Issue
- 21
- Pages
- 7760-7765
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2056014639
- Cited by
- 599
- References
- 34
- FWCI
- 28.30
- Type
- journal article
- Language
- en
- Open access
- green
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