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Cited by 322

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve

Open access
Yu, Jun, deMuinck, Ebo D., Zhuang, Zhenwu, Drinane, Mary, Kauser, Katalin, Rubanyi, Gabor M., Qian, Hu Sheng, Murata, Takahisa, Escalante, Bruno, Sessa, William C.·2005·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0501444102
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Abstract

The genetic loss of endothelial-derived nitric oxide synthase (eNOS) in mice impairs vascular endothelial growth factor (VEGF) and ischemia-initiated blood flow recovery resulting in critical limb ischemia. This result may occur through impaired arteriogenesis, angiogenesis, or mobilization of stem and progenitor cells. Here, we show that after ischemic challenge, eNOS knockout mice [eNOS (-/-)] have defects in arteriogenesis and functional blood flow reserve after muscle stimulation and pericyte recruitment, but no impairment in endothelial progenitor cell recruitment. More importantly, the defects in blood flow recovery, clinical manifestations of ischemia, ischemic reserve capacity, and pericyte recruitment into the growing neovasculature can be rescued by local intramuscular delivery of an adenovirus encoding a constitutively active allele of eNOS, eNOS S1179D, but not a control virus. Collectively, our data suggest that endogenous eNOS-derived NO exerts direct effects in preserving blood flow, thereby promoting arteriogenesis, angiogenesis, and mural cell recruitment to immature angiogenic sprouts.

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Crossref · 10.1073/pnas.0501444102

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Metadata

Authors
Yu, J., deMuinck, E. D., Zhuang, Z., Drinane, M., Kauser, K., Rubanyi, G. M., Qian, H. S., Murata, T., Escalante, B., & Sessa, W. C.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2005-07-25
Volume
102
Issue
31
Pages
10999-11004
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0501444102
OpenAlex
W2166005447
Cited by
322
References
6
FWCI
7.95
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. https://app.cochat.ai/papers/10.1073/pnas.0501444102
The paper
Yu, J., deMuinck, E. D., Zhuang, Z., Drinane, M., Kauser, K., Rubanyi, G. M., Qian, H. S., Murata, T., Escalante, B., & Sessa, W. C. (2005). Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0501444102

Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.