The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
Open accessAbstract
Posttranscriptional gene regulation by microRNAs (miRNAs) is important for many aspects of development, homeostasis, and disease. Here, we show that reduction of endothelial miRNAs by cell-specific inactivation of Dicer , the terminal endonuclease responsible for the generation of miRNAs, reduces postnatal angiogenic response to a variety of stimuli, including exogenous VEGF, tumors, limb ischemia, and wound healing. Furthermore, VEGF regulated the expression of several miRNAs, including the up-regulation of components of the c-Myc oncogenic cluster miR-17-92. Transfection of endothelial cells with components of the miR-17-92 cluster, induced by VEGF treatment, rescued the induced expression of thrombospondin-1 and the defect in endothelial cell proliferation and morphogenesis initiated by the loss of Dicer. Thus, endothelial miRNAs regulate postnatal angiogenesis and VEGF induces the expression of miRNAs implicated in the regulation of an integrated angiogenic response.
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c-Myc-regulated microRNAs modulate E2F1 expression
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Self-citationControl of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
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Dicer is essential for mouse development
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Circulating MicroRNAs in Patients With Coronary Artery Disease
Fichtlscherer, S., De Rosa, S., Fox, H., Schwietz, T., Fischer, A., Liebetrau, C., Weber, M., Hamm, C. W., Röxe, T., Müller-Ardogan, M., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.215566 · Cited by 1,233
Non-coding RNAs as regulators of gene expression and epigenetics
Kaikkonen, M. U., Lam, M. T. Y., & Glass, C. K. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr097 · Cited by 764
Developmental and Pathological Angiogenesis
Chung, A. S., & Ferrara, N. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154002 · Cited by 722
MicroRNAs Add a New Dimension to Cardiovascular Disease
Small, E. M., Frost, R. J. A., & Olson, E. N. (2010) · Circulation · doi:10.1161/circulationaha.109.889048 · Cited by 599
Haemolysis during sample preparation alters microRNA content of plasma
Kirschner, M. B., Kao, S. C., Edelman, J. J., Armstrong, N. J., Vallely, M. P., van Zandwijk, N., & Reid, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024145 · Cited by 569
Metadata
- Authors
- Suárez, Y., Fernández-Hernando, C., Yu, J., Gerber, S. A., Harrison, K. D., Pober, J. S., Iruela-Arispe, M. L., Merkenschlager, M., & Sessa, W. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-09-16
- Volume
- 105
- Issue
- 37
- Pages
- 14082-14087
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079245209
- Cited by
- 488
- References
- 41
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Suárez, Y., Fernández-Hernando, C., Yu, J., Gerber, S. A., Harrison, K. D., Pober, J. S., Iruela-Arispe, M. L., Merkenschlager, M., & Sessa, W. C. (2008). Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0804597105
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