The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Na V 1.9 to sensory transmission and nociceptive behavior
Open accessAbstract
The transmission of pain signals after injury or inflammation depends in part on increased excitability of primary sensory neurons. Nociceptive neurons express multiple subtypes of voltage-gated sodium channels (Na V 1s), each of which possesses unique features that may influence primary afferent excitability. Here, we examined the contribution of Na V 1.9 to nociceptive signaling by studying the electrophysiological and behavioral phenotypes of mice with a disruption of the SCN11A gene, which encodes Na V 1.9. Our results confirm that Na V 1.9 underlies the persistent tetrodotoxin-resistant current in small-diameter dorsal root ganglion neurons but suggest that this current contributes little to mechanical thermal responsiveness in the absence of injury or to mechanical hypersensitivity after nerve injury or inflammation. However, the expression of Na V 1.9 contributes to the persistent thermal hypersensitivity and spontaneous pain behavior after peripheral inflammation. These results suggest that inflammatory mediators modify the function of Na V 1.9 to maintain inflammation-induced hyperalgesia.
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Cites
Neurotrophin-evoked depolarization requires the sodium channel NaV1.9
Blum, R., Kafitz, K. W., & Konnerth, A. (2002) · Nature · doi:10.1038/nature01085 · Cited by 266
Cited by
Nociceptors—Noxious Stimulus Detectors
Woolf, C. J., & Ma, Q. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.016 · Cited by 1,048
The Role of Voltage-Gated Sodium Channels in Pain Signaling
Bennett, D. L., Clark, A. J., Huang, J., Waxman, S. G., & Dib-Hajj, S. D. (2019) · Physiological Reviews · doi:10.1152/physrev.00052.2017 · Cited by 730
The roles of sodium channels in nociception: Implications for mechanisms of pain
Cummins, T. R., Sheets, P. L., & Waxman, S. G. (2007) · Pain · doi:10.1016/j.pain.2007.07.026 · Cited by 485
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons
Rush, A. M., Cummins, T. R., & Waxman, S. G. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.121483 · Cited by 425
Advances in understanding nociception and neuropathic pain
St. John Smith, E. (2018) · Journal of Neurology · doi:10.1007/s00415-017-8641-6 · Cited by 282
Metadata
- Authors
- Priest, B. T., Murphy, B. A., Lindia, J. A., Diaz, C., Abbadie, C., Ritter, A. M., Liberator, P., Iyer, L. M., Kash, S. F., Kohler, M. G., Kaczorowski, G. J., MacIntyre, D. E., & Martin, W. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-06-17
- Volume
- 102
- Issue
- 26
- Pages
- 9382-9387
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2145540995
- Cited by
- 275
- References
- 1
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Priest, B. T., Murphy, B. A., Lindia, J. A., Diaz, C., Abbadie, C., Ritter, A. M., Liberator, P., Iyer, L. M., Kash, S. F., Kohler, M. G., Kaczorowski, G. J., MacIntyre, D. E., & Martin, W. J. (2005). Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Na V 1.9 to sensory transmission and nociceptive behavior. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0501549102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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