Neurotrophin-evoked depolarization requires the sodium channel NaV1.9
Abstract
Brain-derived neurotrophic factor (BDNF) and other neurotrophins are essential for normal brain function. Many types of neurons in the central nervous system are excited by BDNF or neurotrophin-4/5, an action that has recently been implicated in synaptic plasticity. The mechanisms involved in this transmitter-like action of neurotrophins remains unclear. Here, by screening candidate genes with an antisense messenger RNA expression approach and by co-expressing the receptor tyrosine kinase TrkB and various sodium channels, we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin-evoked excitation. These results establish the molecular basis of neurotrophin-evoked depolarization and reveal a mechanism of ligand-mediated sodium channel activation.
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Bath application of a low concentration (20 ng/ml) of BDNF did not by itself induce spine-head enlargement (n=30).
“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [19]
Bath application of 20 ng/ml BDNF did not by itself induce inward currents (0.5 ± 1.2 pA, n=5).
“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [19]
Cites
Efficient selection for high-expression transfectants with a novel eukaryotic vector
Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,135 · see citing works
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394 · see citing works
From Ionic Currents to Molecular Mechanisms
Catterall, W. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)81133-2 · Cited by 2,124 · see citing works
Physiology of the Neurotrophins
Lewin, G. R., & Barde, Y. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001445 · Cited by 1,955 · see citing works
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944 · see citing works
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927 · see citing works
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775 · see citing works
Nomenclature of Voltage-Gated Sodium Channels
Goldin, A. L., Barchi, R. L., Caldwell, J. H., Hofmann, F. B., Howe, J. R., Hunter, J. C., Kallen, R. G., Mandel, G., Meisler, M. H., Berwald‐Netter, Y., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00116-1 · Cited by 1,484 · see citing works
The Trk family of neurotrophin receptors
Barbacid, M. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251107 · Cited by 1,281 · see citing works
Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works
Figurov, A., Pozzo-Miller, L. D., Olafsson, P., Wang, T., & Lu, B. (1996) · Nature · doi:10.1038/381706a0 · Cited by 1,106 · see citing works
Existence of distinct sodium channel messenger RNAs in rat brain
Noda, M., Ikeda, T., Kayano, T., Suzuki, H., Takeshima, H., Kurasaki, M., Takahashi, H., & Numa, S. (1986) · Nature · doi:10.1038/320188a0 · Cited by 905 · see citing works
Encinas, M., Iglesias, M., Liu, Y., Wang, H., Muhaisen, A., Ceña, V., Gallego, C., & Comella, J. X. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750991.x · Cited by 822 · see citing works
Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799 · see citing works
Neurotrophin-evoked rapid excitation through TrkB receptors
Kafitz, K. W., Rose, C. R., Thoenen, H., & Konnerth, A. (1999) · Nature · doi:10.1038/44847 · Cited by 542 · see citing works
Self-citationSynaptic secretion of BDNF after high‐frequency stimulation of glutamatergic synapses
Hartmann, M., Heumann, R., & Leßmann, V. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.5887 · Cited by 513 · see citing works
Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity
McAllister, A. K., Katz, L. C., & Lo, D. C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80239-1 · Cited by 503 · see citing works
Dib‐Hajj, S. D., Tyrrell, L., Black, J. A., & Waxman, S. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8963 · Cited by 502 · see citing works
Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation
Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80378-5 · Cited by 481 · see citing works
Cummins, T., Dib‐Hajj, S. D., Black, J. A., Akopian, A. N., Wood, J. N., & Waxman, S. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-j0001.1999 · Cited by 476 · see citing works
Postsynaptic induction of BDNF-mediated long-term potentiation
Kovalchuk, Y., Hanse, E., Kafitz, K. W., & Konnerth, A. (2002) · Science · doi:10.1126/science.1067766 · Cited by 456 · see citing works
Self-citationGATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei
van Doorninck, J. H., van der Wees, J., Karis, A., Sabel-Goedknegt, E., Coesmans, M., Rutteman, M., Grosveld, F. G., & Zeeuw, C. I. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-j0002.1999 · Cited by 415 · see citing works
Xu, B., Gottschalk, W., Chow, A., Wilson, R. I., Schnell, E., Zang, K., Wang, D., Nicoll, R. A., Lu, B., & Reichardt, L. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06888.2000 · Cited by 401 · see citing works
A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties
Satin, J., Kyle, J. W., Chen, M. J., Bell, P., Cribbs, L. L., Fozzard, H. A., & Rogart, R. B. (1992) · Science · doi:10.1126/science.256.5060.1202 · Cited by 388 · see citing works
Activity-Dependent Transfer of Brain-Derived Neurotrophic Factor to Postsynaptic Neurons
Kohara, K., Kitamura, A., Morishima, M., & Tsumoto, T. (2001) · Science · doi:10.1126/science.1057415 · Cited by 354 · see citing works
Korte, M., Griesbeck, O., Gravel, C., Carroll, P., Staiger, V, Thoenen, H., & Bonhoeffer, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12547 · Cited by 351 · see citing works
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Li, H.-S., Xu, X.-Z. S., & Montell, C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80838-7 · Cited by 345 · see citing works
Kaplan, D. R., Matsumoto, K., Lucarelli, E., & Thielet, C. J. (1993) · Neuron · doi:10.1016/0896-6273(93)90187-v · Cited by 345 · see citing works
Patterson, S. L., Pittenger, C., Morozov, A., Martin, K. C., Scanlin, H., Drake, C., & Kandel, E. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00443-3 · Cited by 334 · see citing works
Primary structure of rat brain sodium channel III deduced from the cDNA sequence
Kayano, T., Noda, M., Flockerzi, V., Takahashi, H., & Numa, S. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80614-8 · Cited by 329 · see citing works
Klugbauer, N., Lacinová, Ľ., Flockerzi, V., & Hofmann, F. B. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07091.x · Cited by 320 · see citing works
Neurotrophin regulation of synaptic transmission
Schuman, E. M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80013-0 · Cited by 309 · see citing works
Neurotrophins and activity-dependent development of the neocortex
Bonhoeffer, T. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80017-1 · Cited by 297 · see citing works
Herzog, R. I., Cummins, T. R., & Waxman, S. G. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.3.1351 · Cited by 295 · see citing works
Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
Tate, S., Benn, S. C., Hick, C. A., Trezise, D. J., John, V. H., Mannion, R., Costigan, M., Plumpton, C., Grose, D., Gladwell, Z. M., et al. (1998) · Nature Neuroscience · doi:10.1038/3652 · Cited by 278 · see citing works
Annexin II light chain regulates sensory neuron-specific sodium channel expression
Okuse, K., Malik‐Hall, M., Baker, M. D., Poon, W.-Y. L., Kong, H., Chao, M. V., & Wood, J. N. (2002) · Nature · doi:10.1038/nature00781 · Cited by 257 · see citing works
Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states
Coward, K., Plumpton, C., Facer, P., Birch, R., Carlstedt, T. P., Tate, S., Bountra, C., & Anand, P. (2000) · Pain · doi:10.1016/s0304-3959(99)00251-1 · Cited by 246 · see citing works
Two tetrodotoxin‐resistant sodium channels in human dorsal root ganglion neurons
Dib‐Hajj, S. D., Tyrrell, L., Cummins, T., Black, J. A., Wood, P. M., & Waxman, S. G. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01519-7 · Cited by 148 · see citing works
Liu, C.-J., Dib-Hajj, S., & Waxman, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101606200 · Cited by 136 · see citing works
Penzotti, J. L., Fozzard, H. A., Lipkind, G. M., & Dudley, S. C. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77710-0 · Cited by 124 · see citing works
A caged Ab reveals an immediate/instructive effect of BDNF during hippocampal synaptic potentiation
Kossel, A. H., Cambridge, S. B., Wagner, U., & Bonhoeffer, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251326998 · Cited by 96 · see citing works
A novel tetrodotoxin-insensitive, slow sodium current in striatal and hippocampal beurons
Hoehn, K., Watson, T., & MacVicar, B. A. (1993) · Neuron · doi:10.1016/0896-6273(93)90341-n · Cited by 81 · see citing works
Yiangou, Y., Birch, R., Sangameswaran, L., Eglen, R. M., & Anand, P. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01166-2 · Cited by 67 · see citing works
Favre, I., Moczydlowski, E. G., & Schild, L. (1995) · The Journal of General Physiology · doi:10.1085/jgp.106.2.203 · Cited by 50 · see citing works
Identification of a Novel Human Voltage-Gated Sodium Channel α Subunit Gene, SCN12A
Jeong, S.-Y., Goto, J., Hashida, H., Suzuki, T., Ogata, K., Masuda, N., Hirai, M., Isahara, K., Uchiyama, Y., & Kanazawa, I. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1916 · Cited by 41 · see citing works
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Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298 · see citing works
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390 · see citing works
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193 · see citing works
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Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055 · see citing works
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Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works
BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942 · see citing works
NEUROTROPHINS: Mediators and Modulators of Pain
Pezet, S., & McMahon, S. B. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112929 · Cited by 877 · see citing works
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works
A simple role for BDNF in learning and memory?
Cunha, C. (2010) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.001.2010 · Cited by 778 · see citing works
Scharfman, H., Goodman, J., Macleod, A., Phani, S., Antonelli, C., & Croll, S. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.11.016 · Cited by 719 · see citing works
Essential role of brain-derived neurotrophic factor in adult hippocampal function
Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685 · see citing works
Neurotrophin secretion: current facts and future prospects
Leßmann, V., Gottmann, K., & Malcangio, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00019-4 · Cited by 664 · see citing works
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines
Tanaka, J.-I., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Science · doi:10.1126/science.1152864 · Cited by 615 · see citing works
New insights into brain BDNF function in normal aging and Alzheimer disease
Tapia‐Arancibia, L., Aliaga, E., Silhol, M., & Arancibia, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.07.007 · Cited by 571 · see citing works
The roles of sodium channels in nociception: Implications for mechanisms of pain
Cummins, T., Sheets, P. L., & Waxman, S. G. (2007) · Pain · doi:10.1016/j.pain.2007.07.026 · Cited by 484 · see citing works
Li, Y., Jia, Y., Cui, K., Li, N., Zheng, Z.-Y., Wang, Y., & Yuan, X. (2005) · Nature · doi:10.1038/nature03477 · Cited by 451 · see citing works
Moody, W. J., & Bosma, M. M. (2005) · Physiological Reviews · doi:10.1152/physrev.00017.2004 · Cited by 394 · see citing works
Voltage‐gated sodium channels and pain pathways
Wood, J. N., Boorman, J. P., Okuse, K., & Baker, M. D. (2004) · Journal of Neurobiology · doi:10.1002/neu.20094 · Cited by 377 · see citing works
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Rose, C. R., Blum, R., Pichler, B., Lepier, A., Kafitz, K. W., & Konnerth, A. (2003) · Nature · doi:10.1038/nature01983 · Cited by 356 · see citing works
Self-citationMerighi, A., Salio, C., Ghirri, A., Lossi, L., Ferrini, F., Betelli, C., & Bardoni, R. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.04.004 · Cited by 356 · see citing works
Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update
Leßmann, V., & Brigadski, T. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.06.004 · Cited by 340 · see citing works
Voltage-Gated Sodium Channels and Hyperalgesia
Lai, J. Y., Porreca, F., Hunter, J. C., & Gold, M. S. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121627 · Cited by 332 · see citing works
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324 · see citing works
Self-citationClinical relevance of the neurotrophins and their receptors
Allen, S. J., & Dawbarn, D. (2006) · Clinical Science · doi:10.1042/cs20050161 · Cited by 316 · see citing works
A de novo gain-of-function mutation in SCN11A causes loss of pain perception
Leipold, E., Liebmann, L., Korenke, G. C., Heinrich, T., Gießelmann, S., Baets, J., Ebbinghaus, M., Goral, R. O., Stödberg, T., Hennings, J. C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2767 · Cited by 309 · see citing works
Self-citationBDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
Gottmann, K., Mittmann, T., & Leßmann, V. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1994-z · Cited by 297 · see citing works
McCutcheon, J. E., & Marinelli, M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06648.x · Cited by 279 · see citing works
Priest, B. T., Murphy, B. A., Lindia, J. A., Diaz, C., Abbadie, C., Ritter, A. M., Liberator, P., Iyer, L. M., Kash, S. F., Köhler, M. G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501549102 · Cited by 275 · see citing works
Zoladz, J. A., & Pilc, A. (2010) · PubMed · Cited by 268 · see citing works
TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders
Gupta, V., You, Y., Gupta, V. B., Klistorner, A. I., & Graham, S. L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140510122 · Cited by 259 · see citing works
Role of neurotrophins in central synapse formation and stabilization
Vicario‐Abejón, C., Owens, D. F., McKay, R. D. G., & Segal, M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn988 · Cited by 247 · see citing works
Neurotrophin-Mediated Rapid Signaling in the Central Nervous System: Mechanisms and Functions
Blum, R., & Konnerth, A. (2005) · Physiology · doi:10.1152/physiol.00042.2004 · Cited by 231 · see citing works
Self-citationLearning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice
Gorski, J. A., Balogh, S. A., Wehner, J. M., & Jones, K. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00426-3 · Cited by 218 · see citing works
Vanhoutte, P., & Bading, H. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00073-4 · Cited by 208 · see citing works
Molecular determinants of retinal ganglion cell development, survival, and regeneration
Isenmann, S. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00027-2 · Cited by 192 · see citing works
Shepherd, R. K., Coco, A., Epp, S. B., & Crook, J. M. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20564 · Cited by 189 · see citing works
Amaral, M. D., & Pozzo-Miller, L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5499-06.2007 · Cited by 214 · see citing works
Rösch, H., Schweigreiter, R., Bonhoeffer, T., Barde, Y., & Körte, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502460102 · Cited by 181 · see citing works
Baker, M. D., Chandra, S. Y., Ding, Y., Waxman, S. G., & Wood, J. N. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00373.x · Cited by 183 · see citing works
Maingret, F., Coste, B., Padilla, F., Clerc, N., Crest, M., Коrogod, S. М., & Delmas, P. (2008) · The Journal of General Physiology · doi:10.1085/jgp.200709935 · Cited by 180 · see citing works
The role of voltage-gated sodium channels in neuropathic pain
Lai, J. Y., Hunter, J. C., & Porreca, F. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00074-6 · Cited by 180 · see citing works
Hoheisel, U., Unger, T., & Mense, S. (2005) · Pain · doi:10.1016/j.pain.2004.12.020 · Cited by 167 · see citing works
Saunders, A. B., Johnson, C. A., & Sabatini, B. L. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00047 · Cited by 165 · see citing works
Signaling mechanisms underlying dendrite formation
Miller, F. D., & Kaplan, D. R. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00072-2 · Cited by 160 · see citing works
Slack, S. E., Pezet, S., McMahon, S. B., Thompson, S., & Malcangio, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03656.x · Cited by 159 · see citing works
Regulation of neuronal survival and death by extracellular signals during development
Davies, A. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg254 · Cited by 157 · see citing works
A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors
Malcangio, M., & Leßmann, V. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00025-7 · Cited by 154 · see citing works
Plasticity compartments in basal dendrites of neocortical pyramidal neurons
Gordon, U., Polsky, A., & Schiller, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3502-06.2006 · Cited by 157 · see citing works
Rugiero, F., Mistry, M., Ciocca, D., Black, J. A., Waxman, S. G., Crest, M., Clerc, N., Delmas, P., & Gola, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02715.2003 · Cited by 143 · see citing works
Brigadski, T., Hartmann, M., & Leßmann, V. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1776-05.2005 · Cited by 142 · see citing works
Arévalo, J. C., Yano, H., Teng, K. K., & Chao, M. V. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600253 · Cited by 139 · see citing works
Gärtner, A., Polnau, D. G., Staiger, V., Sciarretta, C., Minichiello, L., Thoenen, H., Bonhoeffer, T., & Körte, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3792-05.2006 · Cited by 137 · see citing works
Physiological studies of cortical spreading depression
Smith, J. M., Bradley, D. P., James, M. F., & Huang, C. L.-H. (2006) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793106007081 · Cited by 137 · see citing works
Ben‐Shlomo, I., Hsu, S. Y., Rauch, R., Kowalski, H. W., & Hsueh, A. J. W. (2003) · Science s STKE · doi:10.1126/stke.2003.187.re9 · Cited by 135 · see citing works
Brain-Derived Neurotrophic Factor Stimulates Energy Metabolism in Developing Cortical Neurons
Burkhalter, J., Fiumelli, H., Allaman, I., Chatton, J., & Martin, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-23-08212.2003 · Cited by 133 · see citing works
Tozzi, A., Bengtson, C. P., Longone, P., Carignani, C., Fusco, F. R., Bernardi, G., & Mercuri, N. B. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02936.x · Cited by 132 · see citing works
The protean actions of neurotrophins and their receptors on the life and death of neurons
Kalb, R. G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.003 · Cited by 130 · see citing works
The Role of Altered BDNF/TrkB Signaling in Amyotrophic Lateral Sclerosis
Pradhan, J., Noakes, P. G., & Bellingham, M. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00368 · Cited by 126 · see citing works
Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neurons
Coste, B., Osorio, N., Padilla, F., Crest, M., & Delmas, P. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.01.015 · Cited by 125 · see citing works
From modulator to mediator: rapid effects of BDNF on ion channels
Rose, C. R., Blum, R., Kafitz, K. W., Kovalchuk, Y., & Konnerth, A. (2004) · BioEssays · doi:10.1002/bies.20118 · Cited by 124 · see citing works
Self-citationElmariah, S. B., Crumling, M. A., Parsons, T. D., & Balice‐Gordon, R. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4112-03.2004 · Cited by 122 · see citing works
Camuso, S., Rosa, P. L., Fiorenza, M. T., & Canterini, S. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105606 · Cited by 125 · see citing works
Itami, C., Kimura, F., Kohno, T., Matsuoka, M., Ichikawa, M., Tsumoto, T., & Nakamura, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2131948100 · Cited by 120 · see citing works
GTP up‐regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9
Östman, J., Nassar, M. A., Wood, J. N., & Baker, M. D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.147942 · Cited by 112 · see citing works
Thoby‐Brisson, M., Cauli, B., Champagnat, J., Fortin, G., & Katz, D. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07685.2003 · Cited by 102 · see citing works
Madara, J. C., & Levine, E. S. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90880.2008 · Cited by 102 · see citing works
Acute and long-term synaptic modulation by neurotrophins
Lu, B. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)46010-x · Cited by 102 · see citing works
Harte‐Hargrove, L. C., MacLusky, N. J., & Scharfman, H. E. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.029 · Cited by 100 · see citing works
Hill, A. J., Jones, N. A., Smith, I., Hill, C. L., Williams, C. M., Stephens, G. J., & Whalley, B. J. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.03.013 · Cited by 95 · see citing works
Neurotrophin action on a rapid timescale
Kovalchuk, Y., Holthoff, K., & Konnerth, A. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.08.014 · Cited by 91 · see citing works
Self-citationBDNF Therapeutic Mechanisms in Neuropsychiatric Disorders
Bazzari, A. H., & Bazzari, F. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158417 · Cited by 91 · see citing works
de Carrizosa, M. A. D., Morado-Díaz, C. J., Tena, J. J., Benítez‐Temiño, B., Pecero, M. L., Morcuende, S., de la Cruz, R. R., & Pastor, Á. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5312-08.2009 · Cited by 88 · see citing works
Sensory neuron voltage-gated sodium channels as analgesic drug targets
Momin, A., & Wood, J. N. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.08.017 · Cited by 87 · see citing works
Boesmans, W., Gomes, P. M., Janssens, J., Tack, J. F., & Berghe, P. V. (2007) · Gut · doi:10.1136/gut.2007.131839 · Cited by 87 · see citing works
Xiao, M., Xu, L., Laezza, F., Yamada, K. A., Feng, S., & Ornitz, D. M. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.11.020 · Cited by 83 · see citing works
Pettingill, L. N., Richardson, R. T., Wise, A. K., O’Leary, S. J., & Shepherd, R. K. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.895375 · Cited by 84 · see citing works
Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
Vetter, I., Mozar, C. A., Durek, T., Wingerd, J. S., Alewood, P. F., Christie, M. J., & Lewis, R. J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.02.022 · Cited by 83 · see citing works
Nencini, S., Ringuet, M. T., Kim, D.-H., Chen, Y.-J., Greenhill, C., & Ivanusic, J. J. (2017) · Molecular Pain · doi:10.1177/1744806917697011 · Cited by 83 · see citing works
Jang, K., & Garraway, S. M. (2024) · Neurobiology of Pain · doi:10.1016/j.ynpai.2024.100151 · Cited by 78 · see citing works
Airway nerves and dyspnea associated with inflammatory airway disease
Undem, B. J., & Nassenstein, C. (2008) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2008.11.012 · Cited by 79 · see citing works
Leffler, A., Herzog, R. I., Dib‐Hajj, S. D., Waxman, S. G., & Cummins, T. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1463-x · Cited by 79 · see citing works
Lang, S., Stein, V., Bonhoeffer, T., & Löhmann, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3590-06.2007 · Cited by 78 · see citing works
Massey, K. A., Zago, W. M., & Berg, D. K. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.08.011 · Cited by 76 · see citing works
Cechetti, F., Fochesatto, C., Scopel, D. C., Nardin, P., Gonçalves, C. A., Netto, C. A., & Siqueira, I. R. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.012 · Cited by 75 · see citing works
Tyrosine kinases, synaptic plasticity and memory: insights from vertebrates and invertebrates
Purcell, A. L., & Carew, T. J. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.005 · Cited by 73 · see citing works
Understanding Neuropathic Pain
Zieglgänsberger, W., Berthele, A., & Tölle, T. R. (2005) · CNS Spectrums · doi:10.1017/s1092852900022628 · Cited by 69 · see citing works
Amaral, M. D., & Pozzo‐Miller, L. D. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00797.2007 · Cited by 69 · see citing works
Mechanisms of neurotrophin receptor vesicular transport
Yano, H., & Chao, M. V. (2003) · Journal of Neurobiology · doi:10.1002/neu.10321 · Cited by 65 · see citing works
Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer
Montano, X., & Djamgoz, M. B. A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.088 · Cited by 67 · see citing works
Ziemlińska, E., Kügler, S., Schachner, M., Wewiór, I., Czarkowska‐Bauch, J., & Skup, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088833 · Cited by 64 · see citing works
Li, Y., Calfa, G. D., Inoue, T., Amaral, M. D., & Pozzo‐Miller, L. D. (2010) · Journal of Neurophysiology · doi:10.1152/jn.01140.2009 · Cited by 63 · see citing works
Tetrodotoxin‐resistant voltage‐gated sodium channels Nav1.8 and Nav1.9 are expressed in the retina
O’Brien, B. J., Caldwell, J. H., Ehring, G. R., O’Brien, K. M. B., Luo, S., & Levinson, S. R. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21701 · Cited by 64 · see citing works
Guillin, O., Griffon, N., Bézard, E., Leriche, L., Díaz, J., Gross, C. E., & Sokoloff, P. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.096 · Cited by 64 · see citing works
Merighi, A., Bardoni, R., Salio, C., Lossi, L., Ferrini, F., Prandini, M., Zonta, M., Gustincich, S., & Carmignoto, G. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20605 · Cited by 62 · see citing works
Pourcain, B. S., Skuse, D., Mandy, W., Wang, K., Hakonarson, H. H., Timpson, N. J., Evans, D. M., Kemp, J. P., Ring, S. M., McArdle, W. L., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-18 · Cited by 57 · see citing works
Weishaupt, N., Li, S., Pardo, A. D., Sipione, S., & Fouad, K. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.047 · Cited by 60 · see citing works
Mechanism of sodium channel NaV1.9 potentiation by G-protein signaling
Vanoye, C. G., Kunic, J. D., Ehring, G. R., & George, A. L. (2013) · The Journal of General Physiology · doi:10.1085/jgp.201210919 · Cited by 60 · see citing works
Pereira, L. O., Nabinger, P. M., Strapasson, A. C. P., Nardin, P., Gonçalves, C. A., Siqueira, I. R., & Netto, C. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.017 · Cited by 58 · see citing works
Valente, P., Casagrande, S., Nieus, T. R., Verstegen, A. M. J., Valtorta, F., Benfenati, F., & Baldelli, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5275-11.2012 · Cited by 57 · see citing works
Ding, Y., Brackenbury, W. J., Onganer, P. U., Montano, X., Porter, L. M., Bates, L., & Djamgoz, M. B. A. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21289 · Cited by 56 · see citing works
- Authors
- Blum, R., Kafitz, K. W., & Konnerth, A.
- Affiliations
- Physiologisches Institut (DE)
- Corresponding author
- Konnerth, Arthur
- Venue
- Nature
- Published
- 2002-10
- Volume
- 419
- Issue
- 6908
- Pages
- 687-693
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2070568755
- Cited by
- 266
- References
- 45
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 15
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- neurotrophins, brain-derived neurotrophic factor, neurotrophin-4/5, TrkB receptor, synaptic plasticity, neuronal excitation
- MeSH terms
- Animals, Cell Line, Cells, Cultured, Cloning, Molecular, Electric Conductivity, Hippocampus, Humans, Molecular Sequence Data, Nerve Growth Factors, Neuroblastoma, Neurons, Neuropeptides, RNA, Messenger, Saxitoxin, Sodium, Sodium Channels, RNA, Antisense, Rats, Wistar, Brain-Derived Neurotrophic Factor, Receptor, trkB, Rats, NAV1.9 Voltage-Gated Sodium Channel
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