The DOI matches its Crossref record.
Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation
Open accessAbstract
The ability to generate a wide spectrum of differentiated cell types from ES cells in culture offers a powerful approach for studying lineage induction and specification and a promising source of progenitors for cell replacement therapy. Although significant efforts are being made to optimize culture conditions for the generation of different cell populations from ES cells, the identification and efficient isolation of specific progenitors for many lineages within these cultures remains a major challenge. By specifically tracking hematopoietic and cardiac development, we demonstrate here that these two lineages arise from distinct mesoderm subpopulations that develop in sequential waves from pre-mesoderm cells. Access to these populations provides a unique approach to isolate and characterize the earliest progenitors of these lineages.
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Cited by
Lian, X., Hsiao, C., Wilson, G., Zhu, K., Hazeltine, L. B., Azarin, S. M., Raval, K. K., Zhang, J., Kamp, T. J., & Palecek, S. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200250109 · Cited by 1,717
Kattman, S. J., Witty, A. D., Gagliardi, M., Dubois, N. C., Niapour, M., Hotta, A., Ellis, J., & Keller, G. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.12.008 · Cited by 1,159
Self-citationvan den Brink, S. C., Baillie-Johnson, P., Balayo, T., Hadjantonakis, A.-K., Nowotschin, S., Turner, D. A., & Martinez Arias, A. (2014) · Development · doi:10.1242/dev.113001 · Cited by 478
Embryonic Heart Progenitors and Cardiogenesis
Brade, T., Pane, L. S., Moretti, A., Chien, K. R., & Laugwitz, K.-L. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013847 · Cited by 254
Später, D., Hansson, E. M., Zangi, L., & Chien, K. R. (2014) · Development · doi:10.1242/dev.091538 · Cited by 143
Metadata
- Authors
- Kouskoff, V., Lacaud, G., Schwantz, S., Fehling, H. J., & Keller, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-09-02
- Volume
- 102
- Issue
- 37
- Pages
- 13170-13175
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2065535087
- Cited by
- 180
- References
- 0
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Kouskoff, V., Lacaud, G., Schwantz, S., Fehling, H. J., & Keller, G. (2005). Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0501672102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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