Embryonic Heart Progenitors and Cardiogenesis
Open accessAbstract
The mammalian heart is a highly specialized organ, comprised of many different cell types arising from distinct embryonic progenitor populations during cardiogenesis. Three precursor populations have been identified to contribute to different myocytic and nonmyocytic cell lineages of the heart: cardiogenic mesoderm cells (CMC), the proepicardium (PE), and cardiac neural crest cells (CNCCs). This review will focus on molecular cues necessary for proper induction, expansion, and lineage-specific differentiation of these progenitor populations during cardiac development in vivo. Moreover, we will briefly discuss how the knowledge gained on embryonic heart progenitor biology can be used to develop novel therapeutic strategies for the management of congenital heart disease as well as for improvement of cardiac function in ischemic heart disease.
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Cells from the FHF contribute to linear heart tube formation, followed by migrating SHF cells that contribute to further expansion and chamber formation.
“Cells from the FHF contribute to the linear heart tube formation, followed by migrating cells belonging to the SHF that contribute to further expansion and chamber formation36.”
From Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease (2021) · cites this paper as [36]
FHF and SHF are two cell populations found in the developing heart.
“The first and second heart fields (FHF, SHF) are two cell populations found in the developing heart.”
From Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease (2021) · cites this paper as [36]
Most cardiac fibroblasts in embryonic development arise from the proepicardial organ (PEO).
“Most cardiac fibroblasts in embryonic development arise from the PEO36,72,73”
From Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease (2021) · cites this paper as [36]
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Incidence of Congenital Heart Disease—Reply
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Stem Cell Models of Cardiac Development and Disease
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Self-citationReprogramming toward Heart Regeneration: Stem Cells and Beyond
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Epicardial Control of Myocardial Proliferation and Morphogenesis
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Genetic Networks Governing Heart DevelopmentPreprint
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Role of fibroblast growth factor signaling during proepicardium formation in the chick embryo
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Lewis-Israeli, Y. R., Wasserman, A. H., Gabalski, M. A., Volmert, B. D., Ming, Y., Ball, K. A., Yang, W., Zou, J., Ni, G., Pajares, N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25329-5 · Cited by 536 · see citing works
Human heart-forming organoids recapitulate early heart and foregut development
Drakhlis, L., Biswanath, S., Farr, C.-M., Lupanow, V., Teske, J., Ritzenhoff, K., Franke, A., Manstein, F., Bolesani, E., Kempf, H., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00815-9 · Cited by 452 · see citing works
Später, D., Hansson, E. M., Zangi, L., & Chien, K. R. (2014) · Development · doi:10.1242/dev.091538 · Cited by 143 · see citing works
Self-citationThe Hippo signal transduction network in skeletal and cardiac muscle
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Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease
Cui, M., Wang, Z., Bassel-Duby, R., & Olson, E. N. (2018) · Development · doi:10.1242/dev.171983 · Cited by 92 · see citing works
Kuckelkorn, C., Aksoy, E., Stojanovic, N., Oulahyane, L., Ritter, M., Pfannkuche, K., & Fischer, H. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202403897 · Cited by 3 · see citing works
- Authors
- Brade, T., Pane, L. S., Moretti, A., Chien, K. R., & Laugwitz, K.-L.
- Affiliations
- TUM Klinikum (DE)
- Harvard University (US)
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-10-01
- Volume
- 3
- Issue
- 10
- Pages
- a013847-a013847
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC3784811
- OpenAlex
- W2170437462
- Cited by
- 254
- References
- 110
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 27 · 2023: 23 · 2022: 23 · 2021: 24 · 2020: 26 · 2019: 18 · 2018: 19 · 2017: 20 · 2016: 16 · 2015: 17 · 2014: 13 · 2013: 2
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- heart development, proepicardium, cardiac neural crest cells, lineage-specific differentiation, congenital heart disease, ischemic heart disease, cardiac regeneration
- MeSH terms
- Animals, Cell Differentiation, Heart, Heart Defects, Congenital, Humans, Mesoderm, Myocardium, Neural Crest, Pericardium, Neovascularization, Physiologic, Cell Lineage, Regenerative Medicine, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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