The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
Open accessAbstract
Embryo implantation in the uterus is a critical step in mammalian reproduction, requiring preparation of the uterus receptive to blastocyst implantation. Uterine receptivity, also known as the window of implantation, lasts for a limited period, and it is during this period blastocysts normally implant. Ovarian steroid hormones estrogen and progesterone (P(4)) are the primary regulators of this process. The immunophilin FKBP52 serves as a cochaperone for steroid hormone nuclear receptors to govern appropriate hormone action in target tissues. Here we show a critical role for FKBP52 in mouse implantation. This immunophilin has unique spatiotemporal expression in the uterus during implantation, and females missing the Fkbp52 gene have complete implantation failure due to lack of attainment of uterine receptivity. The overlapping uterine expression of FKBP52 with nuclear progesterone receptor (PR) in wild-type mice together with reduced P(4) binding to PR, attenuated PR transcriptional activity and down-regulation of several P(4)-regulated genes in uteri of Fkbp52(-/-) mice, establishes this cochaperone as a critical regulator of uterine P(4) function. Interestingly, ovulation, another P(4)-mediated event, remains normal. Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation.
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In the citing paper
“While FKBP52 is known to functionally interact with AR, GR and PR [6–8], β-catenin only interacts strongly with AR, but not GR and PR [20].”
From The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling (2015) · cites this paper as [8]
In the citing paper
“FKBP52 is a positive regulator of glucocorticoid receptor (GR) [5], progesterone receptor (PR) [6], and androgen receptor (AR) [7], but not estrogen receptor (ER) or mineralocorticoid receptor (MR) [5].”
From FKBP51 and FKBP52 in signaling and disease (2011) · cites this paper as [6]
In the citing paper
“Given the androgen, progesterone and glucocorticoid insensitivity phenotypes observed in the fkbp52-deficient mice [6, 7, 32, 35, 51], FKBP52 is likely to have an important role and to serve as a therapeutic target in a variety of diseases that are dependent on these hormone signaling pathways.”
From FKBP51 and FKBP52 in signaling and disease (2011) · cites this paper as [6]
In the citing paper
“The infertility is the result of embryonic implantation and decidualization failure due to progesterone insensitivity and uterine defects [6, 34, 35].”
From FKBP51 and FKBP52 in signaling and disease (2011) · cites this paper as [6]
In the citing paper
“Recently, Tranguch et al. (29) made mice deficient in FKBP52 and showed that this protein plays an essential role in PR-mediated uterine receptivity to implantation, but they were not able to discriminate between PR-A and PR-B actions.”
From FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform (2006) · cites this paper as [29]
In the citing paper
“Recently, Tranguch et al. (29) made mice deficient in FKBP52 and showed that this protein plays an essential role in PR-mediated uterine receptivity to implantation, but they were not able to discriminate between PR-A and PR-B actions.”
From FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform (2006) · cites this paper as [29]
Citations
Cites
Todaro, G. J., & Green, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.299 · Cited by 2,747
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.Preprint
Lydon, J. P., DeMayo, F. J., Funk, C. R., Mani, S. K., Hughes, A. R., Montgomery, C. A., Shyamala, G., Conneely, O. M., & O’Malley, B. W. (1995) · Genes & Development · doi:10.1101/gad.9.18.2266 · Cited by 1,862
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791
Molecular Cues to Implantation
Dey, S. K., Lim, H. J., Das, S. K., Reese, J., Paria, B. C., Daikoku, T., & Wang, H. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0020 · Cited by 1,120
Self-citationSubgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform
Mulac-Jericevic, B., Mullinax, R. A., DeMayo, F. J., Lydon, J. P., & Conneely, O. M. (2000) · Science · doi:10.1126/science.289.5485.1751 · Cited by 704
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
Ye, X., Hama, K., Contos, J. J. A., Anliker, B., Inoue, A., Skinner, M. K., Suzuki, H., Amano, T., Kennedy, G., Arai, H., et al. (2005) · Nature · doi:10.1038/nature03505 · Cited by 567
Das, S., Wang, X., Paria, B. C., Damm, D. L., Abraham, J. A., Klagsbrun, M., Andrews, G. K., & Dey, S. K. (1994) · Development · doi:10.1242/dev.120.5.1071 · Cited by 563
Self-citationDefective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
Mulac‐Jeričević, B., Lydon, J. P., DeMayo, F. J., & Conneely, O. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1732707100 · Cited by 542
Deciphering the Cross-Talk of Implantation: Advances and Challenges
Paria, B. C., Reese, J., Das, S. K., & Dey, S. K. (2002) · Science · doi:10.1126/science.1071601 · Cited by 486
Self-citationLim, H. J., Ma, L., Ma, W., Maas, R. L., & Dey, S. K. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.6.0284 · Cited by 327
Self-citation
Research works printed but not linked: 4
- Song, H., Lim, H., Paria, B. C., Matsumoto, H., Swift, L. L., Morrow, J., Bonventre, J. V. & Dey, S. K. (2002) Development (Cambridge, U.K.) 129, 2879-2889.
- Das, S. K., Wang, X. N., Paria, B. C., Damm, D., Abraham, J. A., Klagsbrun, M., Andrews, G. K. & Dey, S. K. (1994) Development (Cambridge, U.K.) 120, 1071-1083.
- Das, S. K., Chakraborty, I., Paria, B. C., Wang, X. N., Plowman, G. & Dey, S. K. (1995) Mol. Endocrinol. 9, 691-705.8592515
- McMaster, M. T., Teng, C. T., Dey, S. K. & Andrews, G. K. (1992) Mol. Endocrinol. 6, 101-111.1738363
Cited by
Sorted by citations
Mechanisms of implantation: strategies for successful pregnancy
Cha, J., Sun, X., & Dey, S. K. (2012) · Nature Medicine · doi:10.1038/nm.3012 · Cited by 1,391
Self-citationRoadmap to embryo implantation: clues from mouse models
Wang, H., & Dey, S. K. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1808 · Cited by 1,324
Self-citationCyclic Decidualization of the Human Endometrium in Reproductive Health and Failure
Gellersen, B., & Brosens, J. J. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1045 · Cited by 1,176
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727
Physiological and molecular determinants of embryo implantation
Zhang, S., Lin, H., Kong, S., Wang, S., Wang, H., Wang, H., & Armant, D. R. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.011 · Cited by 598
Self-citation
Metadata
- Authors
- Tranguch, S., Cheung-Flynn, J., Daikoku, T., Prapapanich, V., Cox, M. B., Xie, H., Wang, H., Das, S. K., Smith, D. F., & Dey, S. K.
- Affiliations
- Mayo Clinic in Arizona (US)
- Departments of Pediatrics, Cell and Developmental Biology, Cancer Biology, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232; and Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ 85259
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-09-21
- Volume
- 102
- Issue
- 40
- Pages
- 14326-14331
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1242310
- OpenAlex
- W1567400069
- Cited by
- 232
- References
- 28
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 2 · 2023: 9 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 13 · 2018: 7 · 2017: 12 · 2016: 6 · 2015: 13 · 2014: 23 · 2013: 12 · 2012: 17
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (5T32 DK07563, F32DK068983)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- FKBP52, immunophilins, endometrial receptivity, embryo implantation, progesterone receptor, progesterone signaling, co-chaperones, implantation failure
- MeSH terms
- Animals, Female, Histological Techniques, Mice, Inbred C57BL, Embryo Implantation, Progesterone, Receptors, Progesterone, Uterus, Blotting, Southern, Blotting, Northern, Down-Regulation, In Situ Hybridization, Mice, Knockout, Molecular Chaperones, Reverse Transcriptase Polymerase Chain Reaction, Tacrolimus Binding Proteins, Mice
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