Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
Open accessAbstract
Embryo implantation in the uterus is a critical step in mammalian reproduction, requiring preparation of the uterus receptive to blastocyst implantation. Uterine receptivity, also known as the window of implantation, lasts for a limited period, and it is during this period blastocysts normally implant. Ovarian steroid hormones estrogen and progesterone (P(4)) are the primary regulators of this process. The immunophilin FKBP52 serves as a cochaperone for steroid hormone nuclear receptors to govern appropriate hormone action in target tissues. Here we show a critical role for FKBP52 in mouse implantation. This immunophilin has unique spatiotemporal expression in the uterus during implantation, and females missing the Fkbp52 gene have complete implantation failure due to lack of attainment of uterine receptivity. The overlapping uterine expression of FKBP52 with nuclear progesterone receptor (PR) in wild-type mice together with reduced P(4) binding to PR, attenuated PR transcriptional activity and down-regulation of several P(4)-regulated genes in uteri of Fkbp52(-/-) mice, establishes this cochaperone as a critical regulator of uterine P(4) function. Interestingly, ovulation, another P(4)-mediated event, remains normal. Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation.
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FKBP52 functionally interacts with AR, GR and PR.
“While FKBP52 is known to functionally interact with AR, GR and PR [6–8], β-catenin only interacts strongly with AR, but not GR and PR [20].”
From The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling (2015) · cites this paper as [8]
FKBP52 is a positive regulator of GR, PR, and AR, but not ER or MR.
“FKBP52 is a positive regulator of glucocorticoid receptor (GR) [5], progesterone receptor (PR) [6], and androgen receptor (AR) [7], but not estrogen receptor (ER) or mineralocorticoid receptor (MR) [5].”
From FKBP51 and FKBP52 in signaling and disease (2011) · cites this paper as [6]
Given the androgen, progesterone and glucocorticoid insensitivity phenotypes observed in fkbp52-deficient mice, FKBP52 is likely to have an important role and to serve as a therapeutic target in a variety of diseases dependent on these hormone signaling pathways.
“Given the androgen, progesterone and glucocorticoid insensitivity phenotypes observed in the fkbp52-deficient mice [6, 7, 32, 35, 51], FKBP52 is likely to have an important role and to serve as a therapeutic target in a variety of diseases that are dependent on these hormone signaling pathways.”
From FKBP51 and FKBP52 in signaling and disease (2011) · cites this paper as [6]
Female 52KO mice are infertile due to embryonic implantation and decidualization failure caused by progesterone insensitivity and uterine defects.
“The infertility is the result of embryonic implantation and decidualization failure due to progesterone insensitivity and uterine defects [6, 34, 35].”
From FKBP51 and FKBP52 in signaling and disease (2011) · cites this paper as [6]
Tranguch et al. generated FKBP52-deficient mice and showed that FKBP52 plays an essential role in PR-mediated uterine receptivity to implantation.
“Recently, Tranguch et al. (29) made mice deficient in FKBP52 and showed that this protein plays an essential role in PR-mediated uterine receptivity to implantation, but they were not able to discriminate between PR-A and PR-B actions.”
From FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform (2006) · cites this paper as [29]
Tranguch et al. were not able to discriminate between PR-A and PR-B actions.
“Recently, Tranguch et al. (29) made mice deficient in FKBP52 and showed that this protein plays an essential role in PR-mediated uterine receptivity to implantation, but they were not able to discriminate between PR-A and PR-B actions.”
From FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform (2006) · cites this paper as [29]
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- Authors
- Tranguch, S., Cheung-Flynn, J., Daikoku, T., Prapapanich, V., Cox, M. B., Xie, H., Wang, H., Das, S. K., Smith, D. F., & Dey, S. K.
- Affiliations
- Mayo Clinic in Arizona (US)
- Departments of Pediatrics, Cell and Developmental Biology, Cancer Biology, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232; and Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ 85259
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-09-21
- Volume
- 102
- Issue
- 40
- Pages
- 14326-14331
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1242310
- OpenAlex
- W1567400069
- Cited by
- 232
- References
- 28
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 2 · 2023: 9 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 13 · 2018: 7 · 2017: 12 · 2016: 6 · 2015: 13 · 2014: 23 · 2013: 12 · 2012: 17
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (5T32 DK07563, F32DK068983)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- FKBP52, immunophilins, endometrial receptivity, embryo implantation, progesterone receptor, progesterone signaling, co-chaperones, implantation failure
- MeSH terms
- Animals, Female, Histological Techniques, Mice, Inbred C57BL, Embryo Implantation, Progesterone, Receptors, Progesterone, Uterus, Blotting, Southern, Blotting, Northern, Down-Regulation, In Situ Hybridization, Mice, Knockout, Molecular Chaperones, Reverse Transcriptase Polymerase Chain Reaction, Tacrolimus Binding Proteins, Mice
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