The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice
Open accessAbstract
TALL-1/Blys/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is functionally involved in B cell proliferation. Here, we describe B cell hyperplasia and autoimmune lupus-like changes in transgenic mice expressing TALL-1 under the control of a beta-actin promoter. The TALL-1 transgenic mice showed severe enlargement of spleen, lymph nodes, and Peyer's patches because of an increased number of B220+ cells. The transgenic mice also had hypergammaglobulinemia contributed by elevations of serum IgM, IgG, IgA, and IgE. In addition, a phenotype similar to autoimmune lupus-like disease was also seen in TALL-1 transgenic mice, characterized by the presence of autoantibodies to nuclear antigens and immune complex deposits in the kidney. Prolonged survival and hyperactivity of transgenic B cells may contribute to the autoimmune lupus-like phenotype in these animals. Our studies further confirm TALL-1 as a stimulator of B cells that affect Ig production. Thus, TALL-1 may be a primary mediator in B cell-associated autoimmune diseases.
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Hsu, H., Lacey, D. L., Dunstan, C. R., Solovyev, I., Colombero, A., Timms, E., Tan, H.-L., Elliott, G., Kelley, M. J., Sarosi, I., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3540 · Cited by 1,636
Self-citationTumor necrosis factor: a pleiotropic cytokine and therapuetic target
Tracey, M. D., & Cerami, P. D. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.491 · Cited by 1,063
Cited by
Cheema, G. S., Roschke, V., Hilbert, D. M., & Stohl, W. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200106)44:6<1313::aid-art223>3.0.co;2-s · Cited by 802
Thien, M., Phan, T. G., Gardam, S., Amesbury, M., Basten, A., Mackay, F., & Brink, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.010 · Cited by 746
Autoimmune disease: why and where it occurs
Marrack, P., Kappler, J., & Kotzin, B. L. (2001) · Nature Medicine · doi:10.1038/90935 · Cited by 609
Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival
Novak, A. J., Darce, J. R., Arendt, B. K., Harder, B., Henderson, K., Kindsvogel, W., Gross, J. A., Greipp, P. R., & Jelinek, D. F. (2004) · Blood · doi:10.1182/blood-2003-06-2043 · Cited by 554
The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome
Mariette, X., Roux, S., Zhang, J., Bengoufa, D., Lavie, F., Zhou, T., & Kimberly, R. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.2.168 · Cited by 554
Metadata
- Authors
- Khare, S. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-03-14
- Volume
- 97
- Issue
- 7
- Pages
- 3370-3375
- ISSN
- 0027-8424 (ISSN-L)
- OpenAlex
- W2142187278
- Cited by
- 590
- References
- 2
- FWCI
- 27.13
- Type
- journal article
- Language
- en
- Open access
- green
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