Autoimmune disease: why and where it occurs

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

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Epidemiology and estimated population burden of selected autoimmune diseases in the United States

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Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

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Positional cloning of the APECED gene

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Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

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Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

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bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

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Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

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Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis

Bolland, S. M., & Ravetch, J. V. (2000) · Immunity · doi:10.1016/s1074-7613(00)00027-3 · Cited by 753 · see citing works

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

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Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis

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Genetic Analysis of Autoimmune Disease

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A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.

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Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.

Matsumoto, I., Staub, A., Benoist, C., & Mathis, D. (1999) · Science · doi:10.1126/science.286.5445.1732 · Cited by 667 · see citing works

Systemic Lupus Erythematosus

Kotzin, B. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81108-3 · Cited by 665 · see citing works

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases

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Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis

Clynes, R., Dumitru, C. D., & Ravetch, J. V. (1998) · Science · doi:10.1126/science.279.5353.1052 · Cited by 621 · see citing works

Williams Textbook of Endocrinology

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Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

Becker, K. G., Simon, R. M., Wilson, J., Freidlin, B., Biddison, W. E., McFarland, H. F., & Trent, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9979 · Cited by 591 · see citing works

Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice

Khare, S. D., Sarosi, I., Xia, X.-Z., McCabe, S., Miner, K. T., Solovyev, I., Hawkins, N., Kelley, M. J., Chang, D., Van, G. Y., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3370 · Cited by 584 · see citing works

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

Miller, S. D., Vanderlugt, C. L., Begolka, W. S., Pao, W., Yauch, R. L., Neville, K. L., Katz-Levy, Y., Carrizosa, A., & Kim, B. S. (1997) · Nature Medicine · doi:10.1038/nm1097-1133 · Cited by 565 · see citing works

Th1/Th2 Cells

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Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis

Gross, D. M., Forsthuber, T. G., Tary‐Lehmann, M., Etling, C., Ito, K., Nagy, Z. Á., Field, J. A., Steere, A. C., & Huber, B. T. (1998) · Science · doi:10.1126/science.281.5377.703 · Cited by 517 · see citing works

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.

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Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

Salmon, J. E., Millard, S. S., Schachter, L., Arnett, F. C., Ginzler, E. M., Gourley, M. F., Ramsey‐Goldman, R., Peterson, M. G., & Kimberly, R. P. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118552 · Cited by 468 · see citing works

Chlamydia Infections and Heart Disease Linked Through Antigenic Mimicry

Bachmaier, K., Neu, N., de la Maza, L. M., Pal, S., Hessel, A., & Penninger, J. M. (1999) · Science · doi:10.1126/science.283.5406.1335 · Cited by 415 · see citing works

Myositis autoantibody inhibits histidyl-tRNA synthetase: a model for autoimmunity

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Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

Klein, L., Klugmann, M., Nave, K., Tuohy, V. K., & Kyewski, B. (2000) · Nature Medicine · doi:10.1038/71540 · Cited by 392 · see citing works

Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

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Acceleration of Diabetes in Young Nod Mice with a CD4 + Islet-specific T Cell Clone

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A Genomewide Screen in Multiplex Rheumatoid Arthritis Families Suggests Genetic Overlap with Other Autoimmune Diseases

Jawaheer, D., Seldin, M. F., Amos, C. I., Chen, W. V., Shigeta, R., Monteiro, J., Kern, M., Criswell, L. A., Albani, S., Nelson, J. L., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/319518 · Cited by 365 · see citing works

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

Wong, F. S., Visintin, I., Li, W., Flavell, R. A., & Janeway, C. A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.67 · Cited by 346 · see citing works

Antigen‐induced arthritis in mice

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GENETIC SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS

Vyse, T. J., & Kotzin, B. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.261 · Cited by 311 · see citing works

PRIMARY BILIARY CIRRHOSIS: IDENTIFICATION OF TWO MAJOR M2 MITOCHONDRIAL AUTOANTIGENS

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High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

Anderson, A. C., Nicholson, L. B., Legge, K. L., Turchin, V., Zaghouani, H., & Kuchroo, V. K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.5.761 · Cited by 269 · see citing works

Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization.

Cumberbatch, M., & Kimber, I. (1995) · PubMed Central · Cited by 245 · see citing works

Codon 17 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene in Hashimoto’s Thyroiditis and Addison’s Disease1

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Iodine-Induced Autoimmune Thyroiditis in NOD-H-2h4Mice

Rasooly, L., Burek, C. L., & Rose, N. R. (1996) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1996.0191 · Cited by 226 · see citing works

Human Monocyte–Derived Dendritic Cells Induce Naive T Cell Differentiation into T Helper Cell Type 2 (Th2) or Th1/Th2 Effectors

Tanaka, H., Demeure, C. E., Rubio, M., Delespesse, G., & Sarfati, M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.405 · Cited by 226 · see citing works

Antiislet autoantibodies usually develop sequentially rather than simultaneously

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The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders

Carrasco-Marı́n, E., Shimizu, J., Kanagawa, O., & Unanue, E. R. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.2.450 · Cited by 215 · see citing works

Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

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An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.

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Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan

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Immunological responses of healthy elderly population.

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Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide.

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Molecular Basis for HLA-DQ Associations With IDDM

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Relationship of the Structure of Bacterial Lipopolysaccharides to Its Function in Mitogenesis and Adjuvanticity

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Microbial products induce autoimmune disease by an IL-12-dependent pathway

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Immunoregulatory mechanisms of the eye

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Genetic dissection of systemic lupus erythematosus

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CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo

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The genetics of human systemic lupus erythematosus

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Molecular mimicry: Can epitope mimicry induce autoimmune disease?

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Interleukin‐2 Deficient Mice: A New Model to Study Autoimmunity and Self‐Tolerance

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Molecular mimicry and myasthenia gravis. An autoantigenic site of the acetylcholine receptor alpha-subunit that has biologic activity and reacts immunochemically with herpes simplex virus.

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Use of soluble peptide–DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis

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QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2

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Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice

Vyse, T. J., Rozzo, S. J., Drake, C. G., Izui, S., & Kotzin, B. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.11.5566 · Cited by 130 · see citing works

The I-Ag7 MHC Class II Molecule Linked to Murine Diabetes Is a Promiscuous Peptide Binder

Stratmann, T., Apostolopoulos, V., Mallet-Designe, V., Corper, A. L., Scott, C. A., Wilson, I. A., Kang, A. S., & Teyton, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3214 · Cited by 129 · see citing works

Adult coeliac disease: Prevalence and clinical significance

Cook, H. B., Burt, M. J., Collett, J. A., Whitehead, M. R., Frampton, C. M., & CHAPMAN, B. A. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02290.x · Cited by 127 · see citing works

CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family‐based association study

Holopainen, P., Arvas, M., Sistonen, P., Mustalahti, K., Collin, P., Mäki, M., & Partanen, J. (1999) · Tissue Antigens · doi:10.1034/j.1399-0039.1999.530503.x · Cited by 126 · see citing works

Mimicry peptides of human PDC-E2 163-176 peptide, the immunodominant T-cell epitope of primary biliary cirrhosis

Shimoda, S., Nakamura, M., Shigematsu, H., Tanimoto, H., Gushima, T., Gershwin, E. M., & Ishibashi, H. (2000) · Hepatology · doi:10.1053/jhep.2000.8090 · Cited by 121 · see citing works

Peptide recognition, T cell receptor usage and HLA restriction elements of human heat‐shock protein (hsp) 60 and mycobacterial 65‐kDa hsp‐reactive T cell clones from rheumatoid synovial fluid

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Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.

Vyse, T. J., Drake, C. G., Rozzo, S. J., Roper, E., Izui, S., & Kotzin, B. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118975 · Cited by 116 · see citing works

Evidence for Common Autoimmune Disease Genes Controlling Onset, Severity, and Chronicity Based on Experimental Models for Multiple Sclerosis and Rheumatoid Arthritis

Bergsteinsdóttir, K., Yang, H.-T., Pettersson, U., & Holmdahl, R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.3.1564 · Cited by 112 · see citing works

High Incidence of Thyroiditis and Anti-Thyroid Autoantibodies in NOD Mice

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The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.

Albani, S., Tuckwell, J., Esparza, L., Carson, D. A., & Roudier, J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115580 · Cited by 106 · see citing works

Genetic Dissection of SLE Pathogenesis: Adoptive Transfer of Sle1 Mediates the Loss of Tolerance by Bone Marrow-Derived B Cells

Sobel, E. S., Mohan, C., Morel, L. M., Schiffenbauer, J., & Wakeland, E. K. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.4.2415 · Cited by 105 · see citing works

Major Histocompatibility Complex-Directed Susceptibility to Rheumatoid Arthritis

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The use of a non‐depleting anti‐CD4 monoclonal antibody to re‐establish tolerance to β cells in NOD mice

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Homozygous hereditary C1q deficiency and systemic lupus erythematosus: A new family and the molecular basis of C1q deficiency in three families

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Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart

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Multiple loci for multiple sclerosis

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Tumour necrosis factor and other cytokines in murine lupus

Theofilopoulos, A. N., & Lawson, B. R. (1999) · Annals of the Rheumatic Diseases · doi:10.1136/ard.58.2008.i49 · Cited by 85 · see citing works

B- and T-lymphocytes in Ocular Disease

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Mapping autoimmunity genes

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In Vivo Survival of Viral Antigen–specific T Cells that Induce Experimental Autoimmune Encephalomyelitis

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Mapping and identification of autoimmunity genes

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GENETIC AND ENVIRONMENTAL FACTORS IN THE IMMUNE PATHOGENESIS OF RHEUMATOID ARTHRITIS

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Functionally active cardiac antibodies in chronic Chagas' disease are specifically blocked by Trypanosoma cruzi antigens

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The Genes of Systemic Autoimmunity

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Current cases in which epitope mimicry is considered as a component cause of autoimmune disease: immune-mediated (type 1) diabetes

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HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?

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