The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Premature ovarian failure in androgen receptor-deficient mice
Open accessAbstract
Premature ovarian failure (POF) syndrome, an early decline of ovarian function in women, is frequently associated with X chromosome abnormalities ranging from various Xq deletions to complete loss of one of the X chromosomes. However, the genetic locus responsible for the POF remains unknown, and no candidate gene has been identified. Using the Cre/LoxP system, we have disrupted the mouse X chromosome androgen receptor ( Ar ) gene. Female AR –/– mice appeared normal but developed the POF phenotype with aberrant ovarian gene expression. Eight-week-old female AR –/– mice are fertile, but they have lower follicle numbers and impaired mammary development, and they produce only half of the normal number of pups per litter. Forty-week-old AR –/– mice are infertile because of complete loss of follicles. Genome-wide microarray analysis of mRNA from AR –/– ovaries revealed that a number of major regulators of folliculogenesis were under transcriptional control by AR. Our findings suggest that AR function is required for normal female reproduction, particularly folliculogenesis, and that AR is a potential therapeutic target in POF syndrome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Kitagawa, H., Fujiki, R., Yoshimura, K., Mezaki, Y., Uematsu, Y., Matsui, D., Ogawa, S., Unno, K., Okubo, M., Tokita, A., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00436-7 · Cited by 268
Self-citationRetractedEstrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045
Gubbay, J., Collignon, J., Koopman, P., Capel, B., Economou, A., Münsterberg, A., Vivian, N., Goodfellow, P., & Lovell-Badge, R. (1990) · Nature · doi:10.1038/346245a0 · Cited by 1,676
Growth differentiation factor-9 is required during early ovarian folliculogenesis
Dong, J., Albertini, D. F., Nishimori, K., Kumar, T. R., Lu, N., & Matzuk, M. M. (1996) · Nature · doi:10.1038/383531a0 · Cited by 1,646
Fgf10 is essential for limb and lung formation
Sekine, K., Ohuchi, H., Fujiwara, M., Yamasaki, M., Yoshizawa, T., Sato, T., Yagishita, N., Matsui, D., Koga, Y., Itoh, N., et al. (1999) · Nature Genetics · doi:10.1038/5096 · Cited by 1,231
Self-citationYoshizawa, T., Handa, Y., Uematsu, Y., Takeda, S., Sekine, K., Yoshihara, Y., Kawakami, T., Arioka, K., Sato, H., Uchiyama, Y., et al. (1997) · Nature Genetics · doi:10.1038/ng0897-391 · Cited by 1,177
Self-citationIntercellular Communication in the Mammalian Ovary: Oocytes Carry the Conversation
Matzuk, M. M., Burns, K. H., Viveiros, M. M., & Eppig, J. J. (2002) · Science · doi:10.1126/science.1071965 · Cited by 949
Yan, C., Wang, P., DeMayo, J. L., DeMayo, F. J., Elvin, J. A., Cariño, C., Prasad, S. V., Skinner, S. M., Dunbar, B. S., Dube, J. L., et al. (2001) · Molecular Endocrinology · doi:10.1210/me.15.6.854 · Cited by 835
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
Ohtake, F., Takeyama, K.-I., Matsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., Tohyama, C., Krust, A., Mimura, J., Chambon, P., et al. (2003) · Nature · doi:10.1038/nature01606 · Cited by 798
Self-citationEHRMAN, D. A., BARNES, R. B., & ROSENFIELD, R. L. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-322 · Cited by 502
Cited by
Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts
Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.025 · Cited by 1,013
Self-citationAndrogen Receptor Structure, Function and Biology: From Bench to Bedside.
(2016) · Europe PMC (PubMed Central) · Cited by 623
The Androgen Receptor in Health and Disease
Matsumoto, T., Sakari, M., Okada, M., Yokoyama, A., Takahashi, S., Kouzmenko, A., & Kato, S. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183656 · Cited by 266
Self-citationGougeon, A. (2010) · Annales d'Endocrinologie · doi:10.1016/j.ando.2010.02.021 · Cited by 257
Walters, K. A., Simanainen, U., & Handelsman, D. J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq003 · Cited by 183
Metadata
- Authors
- Shiina, H., Matsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., Metzger, D., Chambon, P., Kanno, J., Yoshikawa, H., & Kato, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-12-22
- Volume
- 103
- Issue
- 1
- Pages
- 224-229
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2132049525
- Cited by
- 331
- References
- 34
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Premature ovarian failure in androgen receptor-deficient mice. https://app.cochat.ai/papers/10.1073/pnas.0506736102
- The paper
- Shiina, H., Matsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., Metzger, D., Chambon, P., Kanno, J., Yoshikawa, H., & Kato, S. (2006). Premature ovarian failure in androgen receptor-deficient mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0506736102
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
