The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Chemokines direct endothelial progenitors into tumor neovessels
Open accessAbstract
Tumor neovasculature substantially derives from sprouting of existing vessels, whereas the functional contribution of bone marrow-derived progenitors to neovessels remains controversial. We used transgenic mouse models of multistep carcinogenesis to monitor incorporation of bone marrow-derived cells into the neovasculature and to elucidate mechanisms of endothelial precursor cell (EPC) recruitment into the tumor microenvironment. We unequivocally demonstrate integration of bone marrow cells into the tumor vasculature as a late event in carcinogenesis that temporally correlates with VEGF release by the tumor and mobilization of circulating EPC in the periphery. Moreover, we demonstrate a chemokine-dependent mechanism of EPC homing into tumor, whereby neovessels of late-stage tumors release a battery of CC chemokines, which direct CCR2 + and CCR5 + progenitors into the vasculature. Thus, we show that tumor vessels promote their own growth and development in a self-amplifying fashion.
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Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759
Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., et al. (2001) · Nature Medicine · doi:10.1038/nm1101-1194 · Cited by 1,860
Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts
Direkze, N. C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M. R., & Wright, N. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1708 · Cited by 530
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Salem, H. K., & Thiemermann, C. (2010) · Stem Cells · doi:10.1002/stem.269 · Cited by 915
New insights into M1/M2 macrophages: key modulators in cancer progression
Liu, J., Geng, X., Hou, J., & Wu, G. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02089-2 · Cited by 501
Circulating Endothelial Progenitor Cells Are Up-Regulated in a Mouse Model of Endometriosis
Becker, C. M., Beaudry, P., Funakoshi, T., Benny, O., Zaslavsky, A., Zurakowski, D., Folkman, J., D'Amato, R. J., & Ryeom, S. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.12.037 · Cited by 81
The role of mesenchymal stem cells in oncology and regenerative medicine
Maliha, K., Syeda Ezze Rukhshan, A., & Amanda L, O. (2017) · Future Oncology · doi:10.2217/fon-2016-0264 · Cited by 5
Xu, M., Fei, J., Xiao, Z.-X., & Yi, Y. (2026) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025106 · Cited by 2
Metadata
- Authors
- Spring, H., Schüler, T., Arnold, B., Hämmerling, G. J., & Ganss, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-12-02
- Volume
- 102
- Issue
- 50
- Pages
- 18111-18116
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975807306
- Cited by
- 242
- References
- 3
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Spring, H., Schüler, T., Arnold, B., Hämmerling, G. J., & Ganss, R. (2005). Chemokines direct endothelial progenitors into tumor neovessels. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0507158102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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