The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy
Open accessAbstract
Imaging living organisms with molecular selectivity typically requires the introduction of specific labels. Many applications in biology and medicine, however, would significantly benefit from a noninvasive imaging technique that circumvents such exogenous probes. In vivo microscopy based on vibrational spectroscopic contrast offers a unique approach for visualizing tissue architecture with molecular specificity. We have developed a sensitive technique for vibrational imaging of tissues by combining coherent anti-Stokes Raman scattering (CARS) with video-rate microscopy. Backscattering of the intense forward-propagating CARS radiation in tissue gives rise to a strong epi-CARS signal that makes in vivo imaging possible. This substantially large signal allows for real-time monitoring of dynamic processes, such as the diffusion of chemical compounds, in tissues. By tuning into the CH 2 stretching vibrational band, we demonstrate CARS imaging and spectroscopy of lipid-rich tissue structures in the skin of a live mouse, including sebaceous glands, corneocytes, and adipocytes, with unprecedented contrast at subcellular resolution.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Compared to spontaneous Raman imaging with typical pixel dwell times of several seconds181920, pixel dwell times in CARS imaging are in the range of microseconds21 and thus significantly faster due to a 105 times higher CARS signal compared to spontaneous Raman scattering22.”
From Label-free in vivo analysis of intracellular lipid droplets in the oleaginous microalga Monoraphidium neglectum by coherent Raman scattering microscopy (2016) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Two-photon laser scanning fluorescence microscopy
Denk, W., Strickler, J. H., & Webb, W. W. (1990) · Science · doi:10.1126/science.2321027 · Cited by 9,488
MCML—Monte Carlo modeling of light transport in multi-layered tissues
Wang, L. V., Jacques, S. L., & Zheng, L. (1995) · Computer Methods and Programs in Biomedicine · doi:10.1016/0169-2607(95)01640-f · Cited by 3,330
Zipfel, W. R., Williams, R. M., Christie, R. H., Nikitin, A. Y., Hyman, B. T., & Webb, W. W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0832308100 · Cited by 1,712
Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering
Zumbusch, A., Holtom, G. R., & Xie, X. S. (1999) · Physical Review Letters · doi:10.1103/physrevlett.82.4142 · Cited by 1,610
Self-citationStudy of Optical Effects Due to an Induced Polarization Third Order in the Electric Field Strength
Maker, P. D., & Terhune, R. W. (1965) · Physical Review · doi:10.1103/physrev.137.a801 · Cited by 1,373
Campagnola, P. J., & Loew, L. M. (2003) · Nature Biotechnology · doi:10.1038/nbt894 · Cited by 1,326
Optical coherence tomography for ultrahigh resolution in vivo imaging
Fujimoto, J. G. (2003) · Nature Biotechnology · doi:10.1038/nbt892 · Cited by 1,039
Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications
Cheng, J., & Xie, X. S. (2003) · The Journal of Physical Chemistry B · doi:10.1021/jp035693v · Cited by 962
Self-citationRajadhyaksha, M. M., González, S., Zavislan, J. M., Anderson, R. R., & Webb, R. H. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00690.x · Cited by 831
Optical properties of intralipid: A phantom medium for light propagation studies
Flock, S. T., Jacques, S. L., Wilson, B. C., Star, W. M., & van Gemert, M. J. C. (1992) · Lasers in Surgery and Medicine · doi:10.1002/lsm.1900120510 · Cited by 573
Research works printed but not linked: 2
- Yodh, A. G., Tromberg, B., Sevick-Muraca, E. & Pine, D., eds. (1997) J. Opt. Soc. Am. A 14, 136-342.
- Potma E. O. Evans C. L. & Xie X. S. (2005) Opt. Lett. in press.
Cited by
Sorted by citations
Items 101–200 of 952
Jermyn, M., Desroches, J., Aubertin, K., St‐Arnaud, K., Madore, W., Montigny, É. D., Guiot, M., Trudel, D., Wilson, B. C., Petrecca, K., et al. (2016) · Physics in Medicine and Biology · doi:10.1088/0031-9155/61/23/r370 · Cited by 132
In VivoCell Tracking With Video Rate Multimodality Laser Scanning Microscopy
Veilleux, I., Spencer, J. A., Biss, D. P., Côté, D. C., & Lin, C. P. (2008) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2007.912751 · Cited by 129
Self-citationIn vivo coherent anti‐Stokes Raman scattering imaging of sciatic nerve tissue
Huff, T. B., & Cheng, J. (2007) · Journal of Microscopy · doi:10.1111/j.1365-2818.2007.01729.x · Cited by 128
Chen, W., Zhang, F., Wang, C., Jia, M., Zhao, X., Liu, Z., Ge, Y., Zhang, Y., & Zhang, H. (2021) · Advanced Materials · doi:10.1002/adma.202004446 · Cited by 127
Label-free imaging of arterial cells and extracellular matrix using a multimodal CARS microscope
Wang, H.-W., Le, T. T., & Cheng, J. (2007) · Optics Communications · doi:10.1016/j.optcom.2007.07.067 · Cited by 127
Intravital microscopy: a novel tool to study cell biology in living animals
Weigert, R., Šrámková, M., Parente, L., Amornphimoltham, P., & Masedunskas, A. (2010) · Histochemistry and Cell Biology · doi:10.1007/s00418-010-0692-z · Cited by 127
Fu, D., & Xie, X. S. (2014) · Analytical Chemistry · doi:10.1021/ac500014b · Cited by 124
Self-citationOzeki, Y., Kitagawa, Y., Sumimura, K., Nishizawa, N., Umemura, W., Kajiyama, S., Fukui, K., & Itoh, K. (2010) · Optics Express · doi:10.1364/oe.18.013708 · Cited by 123
Advances in Biomedical Raman Microscopy
Antonio, K. A., & Schultz, Z. D. (2013) · Analytical Chemistry · doi:10.1021/ac403640f · Cited by 122
Label-Free Cellular Imaging by Broadband Coherent Anti-Stokes Raman Scattering Microscopy
Parekh, S. H., Lee, Y. J., Aamer, K. A., & Cicerone, M. T. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.08.009 · Cited by 121
Sood, D., Tang‐Schomer, M. D., Pouli, D., Mizzoni, C., Raia, N. R., Tai, A., Arkun, K., Wu, J. K., Black, L. D., Scheffler, B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12420-1 · Cited by 119
Fiber delivered probe for efficient CARS imaging of tissues
Balu, M., Liu, G., Chen, Z., Tromberg, B. J., & Potma, E. O. (2010) · Optics Express · doi:10.1364/oe.18.002380 · Cited by 116
Self-citationNano-Raman Scattering Microscopy: Resolution and Enhancement
Kawata, S., Ichimura, T., Taguchi, A., & Kumamoto, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00560 · Cited by 116
Portable all-fiber dual-output widely tunable light source for coherent Raman imaging
Brinkmann, M., Fast, A., Hellwig, T., Pence, I. J., Evans, C. L., & Fallnich, C. (2019) · Biomedical Optics Express · doi:10.1364/boe.10.004437 · Cited by 116
Self-citationA multimodal platform for nonlinear optical microscopy and microspectroscopy
Chen, H., Wang, H., Slipchenko, M. N., Jung, Y., Shi, Y., Zhu, J., Buhman, K. K., & Cheng, J. (2009) · Optics Express · doi:10.1364/oe.17.001282 · Cited by 115
Coherent anti-Stokes Raman scattering: Spectroscopy and microscopy
El‐Diasty, F. (2010) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2010.09.008 · Cited by 114
Biomolecular Imaging with Coherent Nonlinear Vibrational Microscopy
Chung, C., & Potma, E. O. (2012) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-040412-110103 · Cited by 114
Self-citationWang, H.-W., Langohr, I. M., Sturek, M. S., & Cheng, J. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.189316 · Cited by 118
Ma, Y., Liu, S., Yang, H., Wu, Y., Yang, C., Liu, X., Zhao, Q., Wu, H., Liang, J., Li, F., et al. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm13513a · Cited by 113
Dual-phase stimulated Raman scattering microscopy for real-time two-color imaging
He, R., Xu, Y., Zhang, L., Ma, S., Wang, X., Ye, D., & Ji, M. (2016) · Optica · doi:10.1364/optica.4.000044 · Cited by 113
Plaque-associated lipids in Alzheimer’s diseased brain tissue visualized by nonlinear microscopy
Kiškis, J., Fink, H., Nyberg, L. K., Thyr, J., Li, J., & Enejder, A. M. K. (2015) · Scientific Reports · doi:10.1038/srep13489 · Cited by 117
Suhalim, J. L., Boik, J. C., Tromberg, B. J., & Potma, E. O. (2012) · Journal of Biophotonics · doi:10.1002/jbio.201200002 · Cited by 112
Self-citationVibrational spectroscopic methods for cytology and cellular research
Clemens, G., Hands, J. R., Dorling, K. M., & Baker, M. J. (2014) · The Analyst · doi:10.1039/c4an00636d · Cited by 113
High-Throughput Raman Flow Cytometry and Beyond
de Pablo, J. G., Lindley, M., Hiramatsu, K., & Goda, K. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00001 · Cited by 112
Krauss, G., Hanke, T., Sell, A., Träutlein, D., Leitenstorfer, A., Selm, R., Winterhalder, M., & Zumbusch, A. (2009) · Optics Letters · doi:10.1364/ol.34.002847 · Cited by 110
Lim, R. S., Suhalim, J. L., Miyazaki‐Anzai, S., Miyazaki, M., Levi, M., Potma, E. O., & Tromberg, B. J. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m018077 · Cited by 110
Self-citationHuang, K., Li, J., Zhang, C., Tan, Y., & Cheng, J. (2020) · iScience · doi:10.1016/j.isci.2020.100953 · Cited by 110
Fibre‐optic nonlinear optical microscopy and endoscopy
Fu, L., & Gu, M. (2007) · Journal of Microscopy · doi:10.1111/j.1365-2818.2007.01777.x · Cited by 109
Liao, C., Wang, P., Wang, P., Li, J., Lee, H. J., Eakins, G. S., & Cheng, J. (2015) · Science Advances · doi:10.1126/sciadv.1500738 · Cited by 107
Raman Based Molecular Imaging and Analytics: A Magic Bullet for Biomedical Applications!?
Bocklitz, T. W., Guo, S., Ryabchykov, O., Vogler, N., & Popp, J. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04665 · Cited by 107
Nonlinear vibrational microscopy applied to lipid biology
Zumbusch, A., Langbein, W., & Borri, P. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.07.003 · Cited by 105
Intraoperative imaging in pathology-assisted surgery
Voskuil, F. J., Vonk, J., van der Vegt, B., Kruijff, S., Ntziachristos, V., van der Zaag, P. J., Witjes, M. J. H., & van Dam, G. M. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00808-8 · Cited by 105
Tracking of Extracellular Vesicles’ Biodistribution: New Methods and Approaches
Аймалетдинов, А. М., & Gomzikova, M. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911312 · Cited by 105
Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans
Le, T. T., Duren, H. M., Slipchenko, M. N., Hu, C., & Cheng, J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.d000638 · Cited by 103
Weng, S., Xu, X., Li, J., & Wong, S. T. C. (2017) · Journal of Biomedical Optics · doi:10.1117/1.jbo.22.10.106017 · Cited by 104
Adaptive optics for enhanced signal in CARS microscopy
Wright, A. J., Poland, S. P., Girkin, J. M., Freudiger, C. W., Evans, C. L., & Xie, X. S. (2007) · Optics Express · doi:10.1364/oe.15.018209 · Cited by 102
Self-citationPerspective: Coherent Raman scattering microscopy, the future is bright
Zhang, C., & Cheng, J. (2018) · APL Photonics · doi:10.1063/1.5040101 · Cited by 98
Coherent Anti-Stokes Raman Scattering Microscopy and Its Applications
Li, S., Li, Y., Yi, R., Liu, L., & Qu, J. (2020) · Frontiers in Physics · doi:10.3389/fphy.2020.598420 · Cited by 97
A comparative Raman and CARS imaging study of colon tissue
Krafft, C., Ramoji, A., Bielecki, C., Vogler, N., Meyer, T., Akimov, D., Rösch, P., Schmitt, M. P., Dietzek, B., Petersen, I., et al. (2009) · Journal of Biophotonics · doi:10.1002/jbio.200810063 · Cited by 97
Quantitative CARS Spectroscopy Using the Maximum Entropy Method: The Main Lipid Phase Transition
Rinia, H. A., Bonn, M., Mueller, M., & Vartiainen∥, E. M. (2006) · ChemPhysChem · doi:10.1002/cphc.200600481 · Cited by 97
Windbergs, M., Jurna, M., Offerhaus, H. L., Herek, J. L., Kleinebudde, P., & Strachan, C. J. (2009) · Analytical Chemistry · doi:10.1021/ac8020856 · Cited by 96
High-power picosecond fiber source for coherent Raman microscopy
Kieu, K. Q., Saar, B. G., Holtom, G. R., Xie, X. S., & Wise, F. W. (2009) · Optics Letters · doi:10.1364/ol.34.002051 · Cited by 96
Self-citationRaman spectroscopy and CARS microscopy of stem cells and their derivatives
Downes, A., Mouras, R., Bagnaninchi, P., & Elfick, A. P. D. (2011) · Journal of Raman Spectroscopy · doi:10.1002/jrs.2975 · Cited by 94
The application of state-of-the-art technologies to support artwork conservation: Literature review
Borg, B., Dunn, M. A., Ang, A. S. M., & Villis, C. (2020) · Journal of Cultural Heritage · doi:10.1016/j.culher.2020.02.010 · Cited by 94
Review of Stimulated Raman Scattering Microscopy Techniques and Applications in the Biosciences
Li, Y., Shen, B., Li, S., Zhao, Y., Qu, J., & Liu, L. (2020) · Advanced Biology · doi:10.1002/adbi.202000184 · Cited by 96
Ex Vivo Diagnosis of Lung Cancer Using a Raman Miniprobe
Magee, N., Villaumié, J., Marple, E. T., Ennis, M., Elborn, J. S., & McGarvey, J. J. (2009) · The Journal of Physical Chemistry B · doi:10.1021/jp900379w · Cited by 94
Nonlinear Optical Imaging and Raman Microspectrometry of the Cell Nucleus throughout the Cell Cycle
Pliss, A., Kuzmin, A. N., Kachynski, A. V., & Prasad, P. N. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.06.069 · Cited by 94
Coherent anti-Stokes Raman scattering hyperspectral tissue imaging with a wavelength-swept system
Bégin, S., Burgoyne, B., Mercier, V., Villeneuve, A., Vallée, R., & Côté, D. C. (2011) · Biomedical Optics Express · doi:10.1364/boe.2.001296 · Cited by 93
Self-citationLatka, I., Dochow, S., Krafft, C., Dietzek, B., & Popp, J. (2013) · Laser & Photonics Review · doi:10.1002/lpor.201200049 · Cited by 93
The Role of Backscattering in SHG Tissue Imaging
Légaré, F., Pfeffer, C. P., & Olsen, B. R. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.100586 · Cited by 93
A biophysical perspective on the cellulosome: new opportunities for biomass conversion
Ding, S.-Y., Xu, Q., Crowley, M. F., Zeng, Y., Nimlos, M. R., Lamed, R., Bayer, E. A., & Himmel, M. E. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.04.008 · Cited by 93
Nose, K., Ozeki, Y., Kishi, T., Sumimura, K., Nishizawa, N., Fukui, K., Kanematsu, Y., & Itoh, K. (2012) · Optics Express · doi:10.1364/oe.20.013958 · Cited by 91
Imaging metal oxide nanoparticles in biological structures with CARS microscopy
Moger, J., Johnston, B. D., & Tyler, C. R. (2008) · Optics Express · doi:10.1364/oe.16.003408 · Cited by 91
Uckermann, O., Galli, R., Tamošaitytė, S., Leipnitz, E., Geiger, K. D., Schackert, G., Koch, E., Steiner, G. R., & Kirsch, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107115 · Cited by 91
Stimulated Raman spectroscopic imaging by microsecond delay-line tuning
Liao, C., Huang, K., Hong, W., Chen, A. J., Karanja, C. W., Wang, P., Eakins, G. S., & Cheng, J. (2016) · Optica · doi:10.1364/optica.3.001377 · Cited by 89
Shedding new light on lipid functions with CARS and SRS microscopy
Yu, Y., Ramachandran, P. V., & Wang, M. C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.02.003 · Cited by 89
Raman spectroscopy for physiological investigations of tissues and cells
Huser, T. R., & Chan, J. W. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.06.011 · Cited by 89
Raman Spectroscopy and Its Modifications Applied to Biological and Medical Research
Allakhverdiev, E. S., Khabatova, V. V., Kossalbayev, B. D., Zadneprovskaya, E. V., Rodnenkov, O. V., Martynyuk, T. V., Maksimov, G. V., Alwasel, S., Tomo, T., & Allakhverdiev, S. I. (2022) · Cells · doi:10.3390/cells11030386 · Cited by 88
Spectroscopy of the C–H Stretching Vibrational Band in Selected Organic Molecules
Šebek, J., Knaanie, R., Albee, B., Potma, E. O., & Gerber, R. B. (2013) · The Journal of Physical Chemistry A · doi:10.1021/jp4014674 · Cited by 87
Self-citationLabel-free CARS microscopy through a multimode fiber endoscope
Trägårdh, J., Pikálek, T., Šerý, M., Meyer, T., Popp, J., & Čižmár, T. (2019) · Optics Express · doi:10.1364/oe.27.030055 · Cited by 86
Label-free Chemically Specific Imaging in Planta with Stimulated Raman Scattering Microscopy
Mansfield, J., Littlejohn, G. R., Seymour, M. P., Lind, R. J., Perfect, S., & Moger, J. (2013) · Analytical Chemistry · doi:10.1021/ac400266a · Cited by 85
Anti-Stokes excitation of solid-state quantum emitters for nanoscale thermometry
Tran, T. T., Regan, B., Екимов, Е. А., Mu, Z., Zhou, Y., Gao, W., Narang, P., Solntsev, A. S., Toth, M., Aharonovich, I., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav9180 · Cited by 84
Optical Spectroscopy for Noninvasive Monitoring of Stem Cell Differentiation
Downes, A. R., Mouras, R., & Elfick, A. P. D. (2010) · BioMed Research International · doi:10.1155/2010/101864 · Cited by 83
Broadband coherent Raman spectroscopy running at 24,000 spectra per second
Hashimoto, K., Takahashi, M., Ideguchi, T., & Goda, K. (2016) · Scientific Reports · doi:10.1038/srep21036 · Cited by 83
Superresolution four-wave mixing microscopy
Kim, H., Bryant, G. W., & Stranick, S. J. (2012) · Optics Express · doi:10.1364/oe.20.006042 · Cited by 82
Impulsive Brillouin microscopy
Ballmann, C. W., Meng, Z., Traverso, A. J., Scully, M. O., & Yakovlev, V. V. (2017) · Optica · doi:10.1364/optica.4.000124 · Cited by 82
Belsey, N. A., Garrett, N., Contreras-Rojas, L. R., Pickup-Gerlaugh, A. J., Price, G. J., Moger, J., & Guy, R. H. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.11.002 · Cited by 81
In vivo evaluation of demyelination and remyelination in a nerve crush injury model
Bélanger, E., Henry, F. P., Vallée, R., Randolph, M. A., Kochevar, I. E., Winograd, J. M., Lin, C. P., & Côté, D. C. (2011) · Biomedical Optics Express · doi:10.1364/boe.2.002698 · Cited by 81
Self-citationPeroxisome Proliferator-Activated Receptor α Antagonism Inhibits Hepatitis C Virus Replication
Rakić, B., Sagan, S. M., Noestheden, M. R., Bélanger, S., Nan, X., Evans, C. L., Xie, X. S., & Pezacki, J. P. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.10.006 · Cited by 81
Self-citationRise of Raman spectroscopy in neurosurgery: a review
DePaoli, D. T., Lemoine, É., Ember, K. J. I., Parent, M., Prud’homme, M., Cantin, L., Petrecca, K., Leblond, F., & Côté, D. C. (2020) · Journal of Biomedical Optics · doi:10.1117/1.jbo.25.5.050901 · Cited by 83
Self-citationImitola, J., Rasmussen, S., Liu, Y., Chitnis, T., Khoury, S., Côté, D. C., Xie, X. S., Lin, C. P., & Sidman, R. L. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3533312 · Cited by 79
Self-citationLin, C., Potma, E. O., Suhalim, J. L., Nien, C., Jester, J. V., Miljković, M. D., & Diem, M. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3533716 · Cited by 79
Self-citationDual-pump coherent anti-Stokes-Raman scattering microscopy
Burkacky, O., Zumbusch, A., Brackmann, C., & Enejder, A. M. K. (2006) · Optics Letters · doi:10.1364/ol.31.003656 · Cited by 79
Chang, P. V., & Bertozzi, C. R. (2012) · Chemical Communications · doi:10.1039/c2cc31845h · Cited by 83
Optical skin biopsies by clinical CARS and multiphoton fluorescence/SHG tomography
König, K., Breunig, H. G., Bückle, R., Kellner‐Höfer, M., Weinigel, M., Büttner, E., Sterry, W., & Lademann, J. M. (2011) · Laser Physics Letters · doi:10.1002/lapl.201110014 · Cited by 78
In Vivo and in Situ Spectroscopic Imaging by a Handheld Stimulated Raman Scattering Microscope
Liao, C., Wang, P., Huang, C. Y., Lin, P., Eakins, G. S., Bentley, R. T., Liang, R., & Cheng, J. (2017) · ACS Photonics · doi:10.1021/acsphotonics.7b01214 · Cited by 77
Stimulated Raman photoacoustic imaging
Yakovlev, V. V., Zhang, H. F., Noojin, G. D., Denton, M. L., Thomas, R. J., & Scully, M. O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012432107 · Cited by 76
Neurophotonics: optical methods to study and control the brain
Amitonova, L. V., Федотов, И. В., Fedotov, A. B., Anokhin, K. V., & Zheltikov, A. M. (2015) · Uspekhi Fizicheskih Nauk · doi:10.3367/ufnr.0185.201504c.0371 · Cited by 76
Label-free mid-infrared photothermal live-cell imaging beyond video rate
Ishigane, G., Toda, K., Tamamitsu, M., Shimada, H., Badarla, V. R., & Ideguchi, T. (2023) · Light Science & Applications · doi:10.1038/s41377-023-01214-2 · Cited by 82
Noothalapati, H., & Shigeto, S. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.08.020 · Cited by 76
Performance of line-scan Raman microscopy for high-throughput chemical imaging of cell population
Qi, J., & Shih, W. (2014) · Applied Optics · doi:10.1364/ao.53.002881 · Cited by 76
Broadband stimulated Raman scattering with Fourier-transform detection
Réhault, J., Crisafi, F., Kumar, V., Ciardi, G., Marangoni, M., Cerullo, G., & Polli, D. (2015) · Optics Express · doi:10.1364/oe.23.025235 · Cited by 75
Deciphering single cell metabolism by coherent Raman scattering microscopy
Yue, S., & Cheng, J. (2016) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2016.05.016 · Cited by 75
Vielreicher, M., Schürmann, S., Detsch, R., Schmidt, M., Buttgereit, A., Boccaccini, A. R., & Friedrich, O. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.0263 · Cited by 74
Lucas, M., & Riedo, E. (2012) · Review of Scientific Instruments · doi:10.1063/1.4720102 · Cited by 74
Gottschall, T., Meyer, T., Baumgartl, M., Jáuregui, C., Schmitt, M. P., Popp, J., Limpert, J., & Tünnermann, A. (2015) · Laser & Photonics Review · doi:10.1002/lpor.201500023 · Cited by 73
Emerging strategies for labeling and tracking of extracellular vesicles
Li, Y., Wu, J., Wang, J., Hu, X.-B., & Xiang, D. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.056 · Cited by 73
Coherent Raman Scattering Microscopy
Volkmer, A. (2009) · Biological and medical physics series · doi:10.1007/978-3-642-02649-2_6 · Cited by 72
Kim, S., Lee, E.-S., Lee, J. Y., Lee, E. S., Lee, B.-S., Park, J. E., & Moon, D. W. (2010) · Circulation Research · doi:10.1161/circresaha.109.208678 · Cited by 72
Gao, L. S., Zhou, H. S., Thrall, M. J., Li, F., Yang, Y., Wang, Z., Luo, P., Wong, K., Palapattu, G. S., & Wong, S. T. C. (2011) · Biomedical Optics Express · doi:10.1364/boe.2.000915 · Cited by 71
Yang, Y., Li, F., Gao, L. S., Wang, Z., Thrall, M. J., Shen, S. S., Wong, K., & Wong, S. T. C. (2011) · Biomedical Optics Express · doi:10.1364/boe.2.002160 · Cited by 71
A decade of alkyne-tag Raman imaging (ATRI): applications in biological systems
Bakthavatsalam, S., Dodo, K., & Sodeoka, M. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00116g · Cited by 72
Zimmerley, M., McClure, R. A., Choi, B., & Potma, E. O. (2009) · Applied Optics · doi:10.1364/ao.48.000d79 · Cited by 70
Self-citationLin, J., Lu, F., Zheng, W., Huang, Z., Xu, S., Tai, D., & Yu, H. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3655353 · Cited by 73
Background free CARS imaging by phase sensitive heterodyne CARS
Jurna, M., Korterik, J. P., Otto, C., Herek, J. L., & Offerhaus, H. L. (2008) · Optics Express · doi:10.1364/oe.16.015863 · Cited by 70
Raman Imaging of Nanocarriers for Drug Delivery
Vanden-Hehir, S., Tipping, W. J., Lee, M. W., Brunton, V. G., Williams, A., & Hulme, A. N. (2019) · Nanomaterials · doi:10.3390/nano9030341 · Cited by 74
Imaging without Fluorescence: Nonlinear Optical Microscopy for Quantitative Cellular Imaging
Streets, A., Li, A., Chen, T., & Huang, Y. (2014) · Analytical Chemistry · doi:10.1021/ac5013706 · Cited by 70
Multimodal Nonlinear Optical Microscopy and Applications to Central Nervous System Imaging
Huff, T. B., Shi, Y., Fu, Y., Wang, H., & Cheng, J. (2008) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2007.913419 · Cited by 69
Advancing Raman spectroscopy from research to clinic: Translational potential and challenges
Tanwar, S., Paidi, S. K., Prasad, R., Pandey, R., & Barman, I. (2021) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2021.119957 · Cited by 69
Shot noise limited heterodyne detection of CARS signals
Jurna, M., Korterik, J. P., Otto, C., & Offerhaus, H. L. (2007) · Optics Express · doi:10.1364/oe.15.015207 · Cited by 68
Metadata
- Authors
- Evans, C. L., Potma, E. O., Puoris'haag, M., Côté, D., Lin, C. P., & Xie, X. S.
- Affiliations
- Harvard University (US)
- Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138; and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-11
- Volume
- 102
- Issue
- 46
- Pages
- 16807-16812
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1283840
- OpenAlex
- W2148691803
- Cited by
- 957
- References
- 27
- Citations by year
- 2026: 13 · 2025: 29 · 2024: 32 · 2023: 42 · 2022: 38 · 2021: 40 · 2020: 31 · 2019: 45 · 2018: 36 · 2017: 47 · 2016: 70 · 2015: 58 · 2014: 59 · 2013: 54 · 2012: 64
- FWCI
- 21.82
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Spectroscopy and Quantum Chemical Studies
- Keywords
- coherent anti-Stokes Raman scattering microscopy, in vivo tissue imaging, vibrational imaging, noninvasive molecular imaging, skin, sebaceous glands, corneocytes, adipocytes, mouse skin
- MeSH terms
- Animals, Diffusion, Female, Mice, Inbred BALB C, Mice, Hairless, Microscopy, Mineral Oil, Scattering, Radiation, Skin, Spectrum Analysis, Raman, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
