The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Autophagic programmed cell death by selective catalase degradation
Abstract
Autophagy plays a central role in regulating important cellular functions such as cell survival during starvation and control of infectious pathogens. Recently, it has been shown that autophagy can induce cells to die; however, the mechanism of the autophagic cell death program is unclear. We now show that caspase inhibition leading to cell death by means of autophagy involves reactive oxygen species (ROS) accumulation, membrane lipid oxidation, and loss of plasma membrane integrity. Inhibition of autophagy by chemical compounds or knocking down the expression of key autophagy proteins such as ATG7, ATG8, and receptor interacting protein (RIP) blocks ROS accumulation and cell death. The cause of abnormal ROS accumulation is the selective autophagic degradation of the major enzymatic ROS scavenger, catalase. Caspase inhibition directly induces catalase degradation and ROS accumulation, which can be blocked by autophagy inhibitors. These findings unveil a molecular mechanism for the role of autophagy in cell death and provide insight into the complex relationship between ROS and nonapoptotic programmed cell death.
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Cites
The role of autophagy during the early neonatal starvation period
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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
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α-Synuclein Is Degraded by Both Autophagy and the Proteasome
Webb, J. L., Ravikumar, B., Atkins, J., Skepper, J. N., & Rubinsztein, D. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300227200 · Cited by 1,429
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
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Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
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Cited by
Physiological Roles of Mitochondrial Reactive Oxygen Species
Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632
Self-consumption: the interplay of autophagy and apoptosis
Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172
Self-citationReactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
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Ferroptosis is an autophagic cell death process
Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899
Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798
Metadata
- Authors
- Yu, L., Wan, F., Dutta, S., Welsh, S., Liu, Z., Freundt, E., Baehrecke, E. H., & Lenardo, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-03-17
- Volume
- 103
- Issue
- 13
- Pages
- 4952-4957
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017855147
- Cited by
- 667
- References
- 8
- FWCI
- 29.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, L., Wan, F., Dutta, S., Welsh, S., Liu, Z., Freundt, E., Baehrecke, E. H., & Lenardo, M. (2006). Autophagic programmed cell death by selective catalase degradation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0511288103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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