Physiological Roles of Mitochondrial Reactive Oxygen Species
Open accessAbstract
Historically, mitochondrial reactive oxygen species (mROS) were thought to exclusively cause cellular damage and lack a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. Thus, mROS were originally envisioned as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that mROS are critical for healthy cell function. In this Review, we discuss this evidence following some background on the generation and regulation of mROS.
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Modest levels of ROS can contribute to cellular proliferation and survival.
“However, increasing evidence suggests that modest levels of ROS can also contribute to cellular proliferation and survival (Sena and Chandel 2012).”
From Cellular senescence and its effector programs (2014) · cites this paper as Sena and Chandel 2012
At low to moderate levels, ROS act as signaling transducers to activate cancer cell proliferation, migration, invasion, angiogenesis, and drug resistance.
“At low to moderate levels, ROS act as signaling transducers to activate cancer cell proliferation, migration, invasion, angiogenesis, and drug resistance.2, 6, 7”
From Reactive Oxygen Species in Cancer: Current Findings and Future Directions (2021) · cites this paper as [2]
Mitochondrial ROS regulate metabolic adaptation, differentiation, and proliferation.
“Recent studies indicate that mitochondrial ROS regulate metabolic adaptation, differentiation and proliferation (Sena and Chandel, 2012).”
From Mitochondria in the Regulation of Innate and Adaptive Immunity (2015) · cites this paper as Sena and Chandel, 2012
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- Authors
- Sena, L. A., & Chandel, N. S.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Chandel, Navdeep S.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 48
- Issue
- 2
- Pages
- 158-167
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC3484374
- OpenAlex
- W2017275974
- Cited by
- 2,632
- References
- 101
- Citations by year
- 2026: 177 · 2025: 165 · 2024: 159 · 2023: 200 · 2022: 207 · 2021: 254 · 2020: 247 · 2019: 220 · 2018: 202 · 2017: 196 · 2016: 181 · 2015: 176 · 2014: 157 · 2013: 88 · 2012: 2
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (P01HL071643, T32HL076139)
- National Cancer Institute (R01CA123067)
- National Institute of Environmental Health Sciences (F30ES019815)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial reactive oxygen species, oxidative metabolism, oxidative damage, neurodegenerative diseases, diabetes mellitus, cancer, premature aging
- MeSH terms
- Aging, Antioxidants, Autophagy, Cell Differentiation, Humans, Immunity, Mitochondria, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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