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Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals
Open accessAbstract
Rapid evolution driven by positive Darwinian selection is a recurrent theme in male reproductive protein evolution. In contrast, positive selection has never been demonstrated for female reproductive proteins. Here, we perform phylogeny-based tests on three female mammalian fertilization proteins and demonstrate positive selection promoting their divergence. Two of these female fertilization proteins, the zona pellucida glycoproteins ZP2 and ZP3, are part of the mammalian egg coat. Several sites identified in ZP3 as likely to be under positive selection are located in a region previously demonstrated to be involved in species-specific sperm-egg interaction, suggesting the selective pressure is related to male-female interaction. The results provide long-sought evidence for two evolutionary hypotheses: sperm competition and sexual conflict.
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Cited by
Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology
Huelsenbeck, J. P., Ronquist, F., Nielsen, R., & Bollback, J. P. (2001) · Science · doi:10.1126/science.1065889 · Cited by 2,737
Yang, Z., & Nielsen, R. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a004148 · Cited by 1,374
Self-citationSawyer, S. L., Wu, L. I., Emerman, M., & Malik, H. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409853102 · Cited by 688
A quantitative framework for characterizing the evolutionary history of mammalian gene expression
Chen, J., Swofford, R., Johnson, J., Cummings, B. B., Rogel, N., Lindblad-Toh, K., Haerty, W., Palma, F. D., & Regev, A. (2019) · Genome Research · doi:10.1101/gr.237636.118 · Cited by 128
Domain Expansion and Functional Diversification in Vertebrate Reproductive Proteins
Rivera, A. M., Wilburn, D. B., & Swanson, W. J. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac105 · Cited by 6
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Metadata
- Authors
- Swanson, W. J., Yang, Z., Wolfner, M. F., & Aquadro, C. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-02-20
- Volume
- 98
- Issue
- 5
- Pages
- 2509-2514
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2101183221
- Cited by
- 441
- References
- 0
- FWCI
- 17.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Swanson, W. J., Yang, Z., Wolfner, M. F., & Aquadro, C. F. (2001). Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.051605998
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