The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa
Open accessAbstract
The opportunistic pathogenic bacterium Pseudomonas aeruginosa uses quorum-sensing signaling systems as global regulators of virulence genes. There are two quorum-sensing signal receptor and signal generator pairs, LasR–LasI and RhlR–RhlI. The recently completed P. aeruginosa genome-sequencing project revealed a gene coding for a homolog of the signal receptors, LasR and RhlR. Here we describe a role for this gene, which we call qscR . The qscR gene product governs the timing of quorum-sensing-controlled gene expression and it dampens virulence in an insect model. We present evidence that suggests the primary role of QscR is repression of lasI . A qscR mutant produces the LasI-generated signal prematurely, and this results in premature transcription of a number of quorum-sensing-regulated genes. When fed to Drosophila melanogaster , the qscR mutant kills the animals more rapidly than the parental P. aeruginosa . The repression of lasI by QscR could serve to ensure that quorum-sensing-controlled genes are not activated in environments where they are not useful.
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Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
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Cited by
Pseudomonas aeruginosa PAO1 Kills Caenorhabditis elegans by Cyanide Poisoning
Gallagher, L. A., & Manoil, C. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.21.6207-6214.2001 · Cited by 435
Self-citationThe Pseudomonas aeruginosa RpoS regulon and its relationship to quorum sensing
Schuster, M., Hawkins, A. C., Harwood, C. S., & Greenberg, E. P. (2004) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03886.x · Cited by 377
Self-citationPhenazines and their role in biocontrol by Pseudomonas bacteria
Chin‐A‐Woeng, T. F. C., Bloemberg, G. V., & Lugtenberg, B. J. J. (2003) · New Phytologist · doi:10.1046/j.1469-8137.2003.00686.x · Cited by 375
Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection
Korgaonkar, A., Trivedi, U., Rumbaugh, K. P., & Whiteley, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214550110 · Cited by 315
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Metadata
- Authors
- Chugani, S. A., Whiteley, M., Lee, K. M., D'Argenio, D., Manoil, C., & Greenberg, E. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-02-27
- Volume
- 98
- Issue
- 5
- Pages
- 2752-2757
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2019899139
- Cited by
- 445
- References
- 1
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Chugani, S. A., Whiteley, M., Lee, K. M., D'Argenio, D., Manoil, C., & Greenberg, E. P. (2001). QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.051624298
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