The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts
Open accessAbstract
Prostate stem-cell antigen (PSCA) is a cell-surface antigen expressed in normal prostate and overexpressed in prostate cancer tissues. PSCA expression is detected in over 80% of patients with local disease, and elevated levels of PSCA are correlated with increased tumor stage, grade, and androgen independence, including high expression in bone metastases. We evaluated the therapeutic efficacy of anti-PSCA mAbs in human prostate cancer xenograft mouse models by using the androgen-dependent LAPC-9 xenograft and the androgen-independent recombinant cell line PC3-PSCA. Two different anti-PSCA mAbs, 1G8 (IgG1κ) and 3C5 (IgG2aκ), inhibited formation of s.c. and orthotopic xenograft tumors in a dose-dependent manner. Furthermore, administration of anti-PSCA mAbs led to retardation of established orthotopic tumor growth and inhibition of metastasis to distant sites, resulting in a significant prolongation in the survival of tumor-bearing mice. These studies suggest PSCA as an attractive target for immunotherapy and demonstrate the therapeutic potential of anti-PSCA mAbs for the treatment of local and metastatic prostate cancer.
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Cites
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
Clynes, R. A., Towers, T. L., Presta, L. G., & Ravetch, J. V. (2000) · Nature Medicine · doi:10.1038/74704 · Cited by 2,768
Cited by
Novel diagnostic biomarkers for prostate cancer
Madu, C. O., & Lu, Y. (2010) · Journal of Cancer · doi:10.7150/jca.1.150 · Cited by 261
Prostate Stem Cell Antigen Is Overexpressed in Prostate Cancer Metastases
Lam, J. S., Yamashiro, J., Shintaku, I. P., Vessella, R. L., Jenkins, R. B., Horvath, S., Said, J. W., & Reiter, R. E. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1842 · Cited by 211
Self-citationChallita-Eid, P. M., Morrison, K., Etessami, S., An, Z., Morrison, K. J., Perez-Villar, J. J., Raitano, A. B., Jia, X.-C., Gudas, J. M., Kanner, S. B., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3849 · Cited by 99
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Metadata
- Authors
- Saffran, D. C., Raitano, A. B., Hubert, R. S., Witte, O. N., Reiter, R. E., & Jakobovits, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-02-13
- Volume
- 98
- Issue
- 5
- Pages
- 2658-2663
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967366986
- Cited by
- 181
- References
- 1
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Saffran, D. C., Raitano, A. B., Hubert, R. S., Witte, O. N., Reiter, R. E., & Jakobovits, A. (2001). Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.051624698
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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