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Cited by 489

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm

Open access
Turhan, Aslihan, Weiss, Linnea A., Mohandas, Narla, Coller, Barry S., Frenette, Paul S.·2002·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.052522799
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Abstract

Vascular occlusion is the major cause of morbidity and mortality in sickle cell disease but its mechanisms are poorly understood. We demonstrate by using intravital microscopy in mice expressing human sickle hemoglobin (SS) that SS red blood cells (RBCs) bind to adherent leukocytes in inflamed venules, producing vasoocclusion of cremasteric venules. SS mice deficient in P- and E-selectins, which display defective leukocyte recruitment to the vessel wall, are protected from vasoocclusion. These data uncover a previously unsuspected paradigm for the pathogenesis of sickle cell vasoocclusion in which adherent leukocytes play a direct role and suggest that drugs targeting SS RBC–leukocyte or leukocyte–endothelial interactions may prevent or treat the vascular complications of this debilitating disease.

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Show all 3 references

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Cited by

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Metadata

Authors
Turhan, A., Weiss, L. A., Mohandas, N., Coller, B. S., & Frenette, P. S.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2002-03-05
Volume
99
Issue
5
Pages
3047-3051
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.052522799
OpenAlex
W2085961346
Cited by
489
References
3
FWCI
7.29
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm. https://app.cochat.ai/papers/10.1073/pnas.052522799
The paper
Turhan, A., Weiss, L. A., Mohandas, N., Coller, B. S., & Frenette, P. S. (2002). Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.052522799

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.